Interleukin 8 (-251 T>A) polymorphism in children and teenagers infected with Helicobacter pylori.
| Title: | Interleukin 8 (-251 T>A) polymorphism in children and teenagers infected with Helicobacter pylori. |
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| Authors: | Saes M; Faculdade de Medicina de Marília (FAMEMA), rua Lourival Freire, 240, Jardim Fragata, CEP 17519-050 Marília, SP Brazil.; de Labio RW; Faculdade de Medicina de Marília (FAMEMA), rua Lourival Freire, 240, Jardim Fragata, CEP 17519-050 Marília, SP Brazil.; Rasmussen LT; Universidade do Sagrado Coração, Bauru, SP Brazil.; Payão SLM; Faculdade de Medicina de Marília (FAMEMA), rua Lourival Freire, 240, Jardim Fragata, CEP 17519-050 Marília, SP Brazil.; Universidade do Sagrado Coração, Bauru, SP Brazil. |
| Source: | The journal of venomous animals and toxins including tropical diseases [J Venom Anim Toxins Incl Trop Dis] 2017 Apr 08; Vol. 23, pp. 23. Date of Electronic Publication: 2017 Apr 08 (Print Publication: 2017). |
| Publication Type: | Case Reports; Journal Article |
| Language: | English |
| Journal Info: | Publisher: CEVAP Country of Publication: Brazil NLM ID: 101201501 Publication Model: eCollection Cited Medium: Print ISSN: 1678-9199 (Print) Linking ISSN: 16789180 NLM ISO Abbreviation: J Venom Anim Toxins Incl Trop Dis Subsets: PubMed not MEDLINE |
| Imprint Name(s): | Publication: 2019- : Botucatu, SP, Brazil : CEVAP; Original Publication: Botucatu, SP, Brazil : CEVAP, c2003- |
| Abstract: | Background: Helicobacter pylori (H. pylori) is a gram-negative bacterium that colonizes the human stomach and causes a variety of gastric diseases. This study evaluated the correlations between the -251 (T>A) (rs4073) polymorphism of interleukin-8 (IL-8), the etiology of gastric disease, and H. pylori infection in pediatric and adolescent patients.; Methods: DNA samples were obtained from 285 gastric biopsies from pediatric patients. H. pylori was detected by PCR, whereas PCR-RFLP was used to characterize the -251 (T>A) polymorphism of IL-8.; Results: The histological analysis revealed the presence of gastritis in 158 patients (55.44%). H. pylori was found in 71 samples (24.9%). The -251 (T>A) polymorphism revealed that 58 (29.47%) samples were TT, 143 (50.18%) samples were TA, and 84 (20.35%) samples were AA.; Conclusions: Our findings suggest that IL8-251 A allele may be an important risk factor for the development of gastric disease when associated with H. pylori infection. |
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| Contributed Indexing: | Keywords: -251 (T>A); Gastric disease; Helicobacter pylori; Interleukin 8; Polymorphism |
| Entry Date(s): | Date Created: 20170414 Latest Revision: 20200930 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC5385065 |
| DOI: | 10.1186/s40409-017-0113-z |
| PMID: | 28405201 |
| Database: | MEDLINE |
Case Reports; Journal Article