Preoperative Prognostic Factors After Liver Resection for Non-Colorectal, Non-Neuroendocrine Liver Metastases and Validation of the Adam Score in an Asian Population.
| Title: | Preoperative Prognostic Factors After Liver Resection for Non-Colorectal, Non-Neuroendocrine Liver Metastases and Validation of the Adam Score in an Asian Population. |
|---|---|
| Authors: | Sim DPY; Department of Hepatopancreatobiliary and Transplant Surgery, Singapore General Hospital, 20 College Road, Singapore, 169856, Singapore.; University of Glasgow, Glasgow, Scotland, UK.; Goh BKP; Department of Hepatopancreatobiliary and Transplant Surgery, Singapore General Hospital, 20 College Road, Singapore, 169856, Singapore. bsgkp@hotmail.com.; Duke NUS Medical School, Singapore, Singapore. bsgkp@hotmail.com.; Lee SY; Department of Hepatopancreatobiliary and Transplant Surgery, Singapore General Hospital, 20 College Road, Singapore, 169856, Singapore.; Duke NUS Medical School, Singapore, Singapore.; Chan CY; Department of Hepatopancreatobiliary and Transplant Surgery, Singapore General Hospital, 20 College Road, Singapore, 169856, Singapore.; Tan IBH; Duke NUS Medical School, Singapore, Singapore.; Division of Medical Oncology, National Cancer Centre Singapore, Singapore, Singapore.; Cheow PC; Department of Hepatopancreatobiliary and Transplant Surgery, Singapore General Hospital, 20 College Road, Singapore, 169856, Singapore.; Jeyaraj P; Department of Hepatopancreatobiliary and Transplant Surgery, Singapore General Hospital, 20 College Road, Singapore, 169856, Singapore.; Chow PKH; Department of Hepatopancreatobiliary and Transplant Surgery, Singapore General Hospital, 20 College Road, Singapore, 169856, Singapore.; Duke NUS Medical School, Singapore, Singapore.; Ooi LLPJ; Department of Hepatopancreatobiliary and Transplant Surgery, Singapore General Hospital, 20 College Road, Singapore, 169856, Singapore.; Duke NUS Medical School, Singapore, Singapore.; Chung AYF; Department of Hepatopancreatobiliary and Transplant Surgery, Singapore General Hospital, 20 College Road, Singapore, 169856, Singapore. |
| Source: | World journal of surgery [World J Surg] 2018 Apr; Vol. 42 (4), pp. 1073-1084. |
| Publication Type: | Journal Article; Validation Study |
| Language: | English |
| Journal Info: | Publisher: Wiley Country of Publication: United States NLM ID: 7704052 Publication Model: Print Cited Medium: Internet ISSN: 1432-2323 (Electronic) Linking ISSN: 03642313 NLM ISO Abbreviation: World J Surg Subsets: MEDLINE |
| Imprint Name(s): | Publication: 2024- : [Hoboken, NJ] : Wiley; Original Publication: New York, Springer International. |
| MeSH Terms: | Asian People* ; Decision Support Techniques* ; Hepatectomy*; Carcinoma/*secondary ; Liver Neoplasms/*secondary ; Melanoma/*secondary; Carcinoma/ethnology ; Carcinoma/mortality ; Carcinoma/surgery ; Liver Neoplasms/ethnology ; Liver Neoplasms/mortality ; Liver Neoplasms/surgery ; Melanoma/ethnology ; Melanoma/mortality ; Melanoma/surgery ; Neoplasm Recurrence, Local/etiology ; Adult ; Aged ; Female ; Humans ; Male ; Middle Aged ; Preoperative Period ; Prognosis ; Retrospective Studies ; Survival Analysis |
| Abstract: | Background: Historically, the benefit of liver resection for non-colorectal, non-neuroendocrine (NCNN) liver metastases has been controversial. This study aims to determine the preoperative prognostic factors of liver resection for NCNN liver metastases and validate the Adam score in an Asian population.; Methods: Consecutive patients who underwent liver resection for NCNN liver metastases were identified retrospectively from a prospective liver resection database of the single institution between 2001 and 2014. Univariate Cox regression models were used to identify associations with outcome variables. Recurrence-free interval and overall survival were determined using the Kaplan-Meier method and compared using log-rank test.; Results: Seventy-eight consecutive patients were identified, which met the study criteria. Univariate analysis demonstrated that adenocarcinoma histology of primary cancer, disease-free interval and number of nodules were significant predictors of survival. Four of the six components of Adam score were significant predictors of survival. These were the presence of extrahepatic metastases, R2 resection, disease-free interval and type of a primary tumour. The total Adam score was also a significant predictor of survival.; Conclusion: Liver resection for NCNN liver metastases is a safe and viable treatment option in carefully selected patients. Significant preoperative prognostic factors include adenocarcinoma primary tumours, disease-free interval and number of nodules. The total Adam score was a good predictor of overall survival and can be used to risk stratify patients undergoing hepatic resection for NCNN liver metastases. |
| References: | World J Surg Oncol. 2015 May 29;13:191. (PMID: 26022107); Langenbecks Arch Surg. 2010 Mar;395(3):227-34. (PMID: 19998042); Anticancer Res. 2001 Nov-Dec;21(6A):4159-62. (PMID: 11911311); Langenbecks Arch Surg. 2014 Dec;399(8):989-1000. (PMID: 25148767); J Am Coll Surg. 2007 Mar;204(3):372-82. (PMID: 17324770); J Gastrointest Surg. 2016 Jun;20(6):1163-72. (PMID: 26921025); Int J Surg. 2014;12(2):163-8. (PMID: 24342081); Ann Surg. 2016 Jul;264(1):147-154. (PMID: 26445472); J Gastrointest Surg. 2012 Oct;16(10):1981-92. (PMID: 22829240); Ann Surg Oncol. 2005 Oct;12(10):778-85. (PMID: 16132374); Ann Surg. 2005 Feb;241(2):269-76. (PMID: 15650637); J Am Coll Surg. 2012 May;214(5):769-77. (PMID: 22425166); J Am Coll Surg. 2003 Jul;197(1):29-37. (PMID: 12831921); ANZ J Surg. 2016 Aug 3;:null. (PMID: 27490345); Ann Surg. 2006 Oct;244(4):524-35. (PMID: 16998361); Ann Surg Oncol. 2008 Jan;15(1):207-18. (PMID: 17963007); Br J Cancer. 2006 Apr 10;94(7):982-99. (PMID: 16538219); HPB (Oxford). 2007;9(6):435-9. (PMID: 18345290); Ann Surg Oncol. 2015 Dec;22 Suppl 3:S1083-92. (PMID: 26242369); PLoS One. 2015 Mar 26;10(3):e0120569. (PMID: 25811923); Int J Surg. 2015 Oct;22:136-42. (PMID: 26277530); ANZ J Surg. 2017 Oct;87(10 ):810-814. (PMID: 27037839); Br J Surg. 2016 Sep;103(10 ):1366-76. (PMID: 27306949); Surgery. 2012 May;151(5):710-6. (PMID: 22285778); Ann Surg. 2009 Aug;250(2):187-96. (PMID: 19638912) |
| Entry Date(s): | Date Created: 20170907 Date Completed: 20180822 Latest Revision: 20221207 |
| Update Code: | 20260130 |
| DOI: | 10.1007/s00268-017-4208-z |
| PMID: | 28875334 |
| Database: | MEDLINE |
Journal Article; Validation Study