Fresh tissue parathyroid allotransplantation with short-term immunosuppression: 1-year follow-up.
| Title: | Fresh tissue parathyroid allotransplantation with short-term immunosuppression: 1-year follow-up. |
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| Authors: | Yucesan E; Institute of Life Sciences and Biotechnology, Bezmialem Vakif University, Istanbul, Turkey.; Goncu B; Experimental Research Center, Bezmialem Vakif University, Istanbul, Turkey.; Basoglu H; Department of Biophysics, Faculty of Medicine, Bezmialem Vakif University, Istanbul, Turkey.; Ozten Kandas N; Department of Pharmaceutical Toxicology, Faculty of Pharmacy, Bezmialem Vakif University, Istanbul, Turkey.; Ersoy YE; Department of General Surgery, Faculty of Medicine, Bezmialem Vakif University, Istanbul, Turkey.; Akbas F; Department of Medical Biology, Faculty of Medicine, Bezmialem Vakif University, Istanbul, Turkey.; Aysan E; Department of General Surgery, Faculty of Medicine, Bezmialem Vakif University, Istanbul, Turkey. |
| Source: | Clinical transplantation [Clin Transplant] 2017 Nov; Vol. 31 (11). Date of Electronic Publication: 2017 Oct 16. |
| Publication Type: | Case Reports; Journal Article |
| Language: | English |
| Journal Info: | Publisher: Munksgaard Country of Publication: Denmark NLM ID: 8710240 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1399-0012 (Electronic) Linking ISSN: 09020063 NLM ISO Abbreviation: Clin Transplant Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Copenhagen : Munksgaard |
| MeSH Terms: | Immunosuppression Therapy* ; Living Donors*; Hypoparathyroidism/*therapy ; Parathyroid Glands/*transplantation ; Postoperative Complications/*prevention & control; Adult ; Female ; Humans ; Male ; Prognosis |
| Abstract: | Background: Permanent hypoparathyroidism is a serious problem and requires medications indefinitely. Parathyroid allotransplantation (PA) with short-term immunosuppression is definitive choice but long-term results are not clear.; Method: We performed PA from two donors to two recipients. Both recipients were 39-year-old females. Donors were a 32-year-old female and a 36-year-old male, who both have chronic kidney disease. Routine tests, viral markers, and cross-matches were analyzed individually. The parathyroid glands were resected from the living donors, fragmented quickly in the operation room and injected into the left deltoid muscles of the two recipients.; Results: Methylprednisolone was administered on post-PA day one and two. Recipients were discharged from the hospital without complications. Calcium and PTH levels were observed throughout 1 year. We did not observe any complications during the follow-up period. Medications ceased in post-transplantation week 1 for Case 1 and after 1 month for Case 2.; Conclusion: Fresh tissue PA with short-term immunosuppression appears to be a promising technique that is easy to perform, is cost-effective, has low risk of side effects and minimal complications with compatibility for HLA conditions. A longer follow-up period and more case studies are needed to determine the risks and benefits of this procedure for future cases.; (© 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.) |
| Contributed Indexing: | Keywords: allotransplantation; immunosuppression; parathyroid; permanent hypoparathyroidism; tissue |
| Entry Date(s): | Date Created: 20171019 Date Completed: 20180627 Latest Revision: 20211204 |
| Update Code: | 20260130 |
| DOI: | 10.1111/ctr.13086 |
| PMID: | 29044732 |
| Database: | MEDLINE |
Case Reports; Journal Article