Anti-protein and anti-bacterial behavior of amphiphilic silicones.
| Title: | Anti-protein and anti-bacterial behavior of amphiphilic silicones. |
|---|---|
| Authors: | Hawkins ML; Department of Biomedical Engineering, Texas A&M University, College Station, TX 77843-3120.; Schott SS; Department of Biomedical Engineering, Texas A&M University, College Station, TX 77843-3120.; Grigoryan B; Department of Biomedical Engineering, Texas A&M University, College Station, TX 77843-3120.; Rufin MA; Department of Biomedical Engineering, Texas A&M University, College Station, TX 77843-3120.; Ngo BKD; Department of Biomedical Engineering, Texas A&M University, College Station, TX 77843-3120.; Vanderwal L; Office of Research & Creative Activity, North Dakota State University, Fargo, ND 58102.; Stafslien SJ; Office of Research & Creative Activity, North Dakota State University, Fargo, ND 58102.; Grunlan MA; Department of Biomedical Engineering, Texas A&M University, College Station, TX 77843-3120.; Department of Materials Science and Engineering, Texas A&M University, College Station, TX 77843-300.; Center for Remote Health Technologies System, Texas A&M University, College Station, TX 77843-3120. |
| Source: | Polymer chemistry [Polym Chem] 2017 Sep 14; Vol. 8 (34), pp. 5239-5251. Date of Electronic Publication: 2017 Jul 18. |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101562526 Publication Model: Print-Electronic Cited Medium: Print ISSN: 1759-9954 (Print) Linking ISSN: 17599954 NLM ISO Abbreviation: Polym Chem Subsets: PubMed not MEDLINE |
| Imprint Name(s): | Original Publication: Cambridge, England : Royal Society of Chemistry |
| Abstract: | Silicones with improved water-driven surface hydrophilicity and anti-biofouling behavior were achieved when bulk-modified with poly(ethylene oxide) (PEO) -silane amphiphiles of varying siloxane tether length: α-(EtO)3Si-(CH2)2-oligodimethylsiloxane m -block-poly(ethylene oxide)8-OCH3 (m = 0, 4, 13, 17, 24, and 30). A PEO8-silane [α-(EtO)3Si-(CH2)3-PEO8-OCH3] served as a conventional PEO-silane control. To examine anti-biofouling behavior in the absence versus presence of water-driven surface restructuring, the amphiphiles and control were surface-grafted onto silicon wafers and used to bulk-modify a medical-grade silicone, respectively. While the surface-grafted PEO-control exhibited superior protein resistance, it failed to appreciably restructure to the surface-water interface of bulk-modified silicone and thus led to poor protein resistance. In contrast, the PEO-silane amphiphiles, while less protein-resistant when surface-grafted onto silicon wafers, rapidly and substantially restructured in bulk-modified silicone, exhibiting superior hydrophilicity and protein resistance. A reduction of biofilm for several strains of bacteria and a fungus was observed for silicones modified with PEO-silane amphiphiles. Longer siloxane tethers maintained surface restructuring and protein resistance while displaying the added benefit of increased transparency. |
| References: | Colloids Surf B Biointerfaces. 2005 Jul 10;43(3-4):208-15. (PMID: 15978785); J Biomed Mater Res A. 2014 Dec;102(12):4244-51. (PMID: 24464985); J Biol Chem. 1983 May 10;258(9):5710-5. (PMID: 6853541); J Biomater Sci Polym Ed. 2000;11(11):1121-34. (PMID: 11263803); J Comb Chem. 2009 Nov-Dec;11(6):1115-27. (PMID: 19807064); Biomaterials. 2005 May;26(15):2391-9. (PMID: 15585242); J Biomater Sci Polym Ed. 1995;7(2):159-69. (PMID: 7654630); Biomaterials. 2000 Mar;21(6):605-16. (PMID: 10701461); Biomacromolecules. 2007 Aug;8(8):2379-87. (PMID: 17608449); Green Mater. 2017 Mar;5(1):4-13. (PMID: 31673356); J Biomed Mater Res B Appl Biomater. 2007 Apr;81(1):251-60. (PMID: 17022059); J Comb Chem. 2006 Mar-Apr;8(2):156-62. (PMID: 16529509); Int J Oral Sci. 2015 Mar 23;7(1):1-7. (PMID: 25504208); Biophys J. 2000 Sep;79(3):1400-14. (PMID: 10969002); Biomaterials. 1998 May;19(10):953-60. (PMID: 9690837); Biomaterials. 2006 Mar;27(8):1341-5. (PMID: 16183113); Biomaterials. 2009 May;30(13):2433-9. (PMID: 19232435); Lancet Infect Dis. 2007 Oct;7(10):645-57. (PMID: 17897607); Biosci Rep. 2002 Apr;22(2):225-50. (PMID: 12428902); Biomaterials. 1998 Sep;19(18):1669-75. (PMID: 9840002); J Colloid Interface Sci. 2005 Jan 1;281(1):112-21. (PMID: 15567386); Biomaterials. 2004 May;25(12):2273-82. (PMID: 14741592); J Mater Chem B. 2015 Apr 14;3(14):2816-2825. (PMID: 26339488); Expert Rev Med Devices. 2005 Jul;2(4):473-92. (PMID: 16293086); J Mater Chem B. 2014 Sep 14;2(34):5689-5697. (PMID: 32262202); J Mol Recognit. 2007 May-Jun;20(3):154-84. (PMID: 17582799); Biomaterials. 2006 Feb;27(6):847-55. (PMID: 16099496); J Biomed Mater Res. 1998 May;40(2):314-23. (PMID: 9549627); J Biomater Sci Polym Ed. 2005;16(4):531-48. (PMID: 15887658); Microbiology (Reading). 2006 Sep;152(Pt 9):2673-2682. (PMID: 16946262); Biomacromolecules. 2007 Oct;8(10):3244-52. (PMID: 17725363); J Biomed Mater Res. 1999 Feb;44(2):130-9. (PMID: 10397913); Chem Commun (Camb). 2014 Mar 25;50(24):3234-7. (PMID: 24522254); J Med Microbiol. 2015 Apr;64(Pt 4):323-334. (PMID: 25670813); Macromolecules. 1998 Jul 28;31(15):5059-70. (PMID: 9680446) |
| Grant Information: | R01 DK095101 United States DK NIDDK NIH HHS |
| Entry Date(s): | Date Created: 20171107 Latest Revision: 20240327 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC5667680 |
| DOI: | 10.1039/C7PY00944E |
| PMID: | 29104619 |
| Database: | MEDLINE |
Journal Article