Mobile microscopy as a screening tool for oral cancer in India: A pilot study.
| Title: | Mobile microscopy as a screening tool for oral cancer in India: A pilot study. |
|---|---|
| Authors: | Skandarajah A; Department of Bioengineering, University of California, Berkeley, CA, United States of America.; Sunny SP; Head and Neck Oncology, Mazumdar Shaw Medical Centre, NH Health city, Bangalore, India.; Integrated Head and Neck Oncology Program (DSRG-5), Mazumdar Shaw Center for Translational Research, Mazumdar Shaw Medical Foundation, NH Health City, Bangalore, India.; Gurpur P; Siemens Healthcare Pvt Ltd, Bangalore, India.; Reber CD; Department of Bioengineering, University of California, Berkeley, CA, United States of America.; D'Ambrosio MV; Department of Bioengineering, University of California, Berkeley, CA, United States of America.; Raghavan N; Department of Pathology, Mazumdar Shaw Medical Centre, NH Health City, Bangalore, India.; James BL; Integrated Head and Neck Oncology Program (DSRG-5), Mazumdar Shaw Center for Translational Research, Mazumdar Shaw Medical Foundation, NH Health City, Bangalore, India.; Ramanjinappa RD; Integrated Head and Neck Oncology Program (DSRG-5), Mazumdar Shaw Center for Translational Research, Mazumdar Shaw Medical Foundation, NH Health City, Bangalore, India.; Suresh A; Head and Neck Oncology, Mazumdar Shaw Medical Centre, NH Health city, Bangalore, India.; Integrated Head and Neck Oncology Program (DSRG-5), Mazumdar Shaw Center for Translational Research, Mazumdar Shaw Medical Foundation, NH Health City, Bangalore, India.; Kandasarma U; Department of Oral and Maxillofacial Pathology, KLE Society's Institute of Dental Sciences, Bangalore, India.; Birur P; Department of oral medicine and radiology, KLE Society's Institute of Dental Sciences, Bangalore, India.; Kumar VV; Head and Neck Oncology, Mazumdar Shaw Medical Centre, NH Health city, Bangalore, India.; Galmeanu HC; Siemens S.R.L, Brasov, Romania.; Itu AM; Siemens S.R.L, Brasov, Romania.; Modiga-Arsu M; Siemens S.R.L, Brasov, Romania.; Rausch S; Siemens Healthcare GmbH, Erlangen, Germany.; Sramek M; Siemens Healthcare GmbH, Erlangen, Germany.; Kollegal M; Siemens Healthcare Pvt Ltd, Bangalore, India.; Paladini G; Siemens Medical Solutions USA Inc., Princeton, NJ, United States of America.; Kuriakose M; Head and Neck Oncology, Mazumdar Shaw Medical Centre, NH Health city, Bangalore, India.; Integrated Head and Neck Oncology Program (DSRG-5), Mazumdar Shaw Center for Translational Research, Mazumdar Shaw Medical Foundation, NH Health City, Bangalore, India.; Ladic L; Siemens Medical Solutions USA Inc., Princeton, NJ, United States of America.; Koch F; Department of Oral and Maxillofacial Surgery-Plastic Surgery, University of Mainz, Mainz, Germany.; Fletcher D; Department of Bioengineering, University of California, Berkeley, CA, United States of America. |
| Source: | PloS one [PLoS One] 2017 Nov 27; Vol. 12 (11), pp. e0188440. Date of Electronic Publication: 2017 Nov 27 (Print Publication: 2017). |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: San Francisco, CA : Public Library of Science |
| MeSH Terms: | Cell Phone*; Early Detection of Cancer/*methods ; Microscopy/*methods ; Mouth Neoplasms/*diagnosis; Mouth Neoplasms/pathology ; Adult ; Aged ; Automation ; Demography ; Female ; Humans ; Image Processing, Computer-Assisted ; India ; Male ; Middle Aged ; Pilot Projects ; Sensitivity and Specificity ; User-Computer Interface ; Young Adult |
| Abstract: | Oral cancer is the most common type of cancer among men in India and other countries in South Asia. Late diagnosis contributes significantly to this mortality, highlighting the need for effective and specific point-of-care diagnostic tools. The same regions with high prevalence of oral cancer have seen extensive growth in mobile phone infrastructure, which enables widespread access to telemedicine services. In this work, we describe the evaluation of an automated tablet-based mobile microscope as an adjunct for telemedicine-based oral cancer screening in India. Brush biopsy, a minimally invasive sampling technique was combined with a simplified staining protocol and a tablet-based mobile microscope to facilitate local collection of digital images and remote evaluation of the images by clinicians. The tablet-based mobile microscope (CellScope device) combines an iPad Mini with collection optics, LED illumination and Bluetooth-controlled motors to scan a slide specimen and capture high-resolution images of stained brush biopsy samples. Researchers at the Mazumdar Shaw Medical Foundation (MSMF) in Bangalore, India used the instrument to collect and send randomly selected images of each slide for telepathology review. Evaluation of the concordance between gold standard histology, conventional microscopy cytology, and remote pathologist review of the images was performed as part of a pilot study of mobile microscopy as a screening tool for oral cancer. Results indicated that the instrument successfully collected images of sufficient quality to enable remote diagnoses that show concordance with existing techniques. Further studies will evaluate the effectiveness of oral cancer screening with mobile microscopy by minimally trained technicians in low-resource settings. |
| References: | Lab Chip. 2009 Mar 21;9(6):777-87. (PMID: 19255659); Telemed J E Health. 2012 Sep;18(7):516-20. (PMID: 22856666); Acta Cytol. 1998 May-Jun;42(3):663-7. (PMID: 9622684); Head Neck Oncol. 2009 Jan 30;1:5. (PMID: 19284694); J Am Dent Assoc. 1999 Oct;130(10):1445-57. (PMID: 10570588); PLoS One. 2014 May 13;9(5):e96906. (PMID: 24824072); Oral Surg Oral Med Oral Pathol Oral Radiol. 2012 Jun;113(6):799-807. (PMID: 22668708); Biochem J. 2012 Apr 15;443(2):339-53. (PMID: 22452816); Oral Oncol. 2010 Jun;46(6):407-10. (PMID: 20403722); Oral Dis. 2010 May;16(4):333-42. (PMID: 20233328); N Engl J Med. 2007 May 10;356(19):1944-56. (PMID: 17494927); Clin Oral Investig. 2011 Oct;15(5):763-9. (PMID: 20593209); J Am Dent Assoc. 2015 Dec;146(12 ):886-94. (PMID: 26610833); Oral Oncol. 2009 Apr-May;45(4-5):340-50. (PMID: 18674956); Int J Oral Maxillofac Surg. 2005 Jul;34(5):521-7. (PMID: 16053872); Cancer Prev Res (Phila). 2012 Jun;5(6):801-9. (PMID: 22551901); Biochem Med (Zagreb). 2012;22(3):276-82. (PMID: 23092060); J Cancer Res Ther. 2012 Apr-Jun;8(2):192-8. (PMID: 22842360); Am J Clin Pathol. 2003 Mar;119(3):356-60. (PMID: 12645336); Anal Chem. 2008 May 15;80(10):3699-707. (PMID: 18407617); Microsc Res Tech. 2001 Feb 1;52(3):251-62. (PMID: 11180618); Lancet. 2012 May 12;379(9828):1807-16. (PMID: 22460346); PLoS One. 2009 Jul 22;4(7):e6320. (PMID: 19623251); Cochrane Database Syst Rev. 2006 Jul 19;(3):CD004150. (PMID: 16856035); Cancer. 1980 Aug 15;46(4):758-63. (PMID: 7397638); Biomed Opt Express. 2012 Jul 1;3(7):1632-46. (PMID: 22808434); Telemed J E Health. 2011 Sep;17(7):565-8. (PMID: 21851161); Oral Oncol. 2004 Sep;40(8):829-34. (PMID: 15288839); PLoS One. 2011;6(12):e28348. (PMID: 22194829); Oral Oncol. 2008 Jan;44(1):10-22. (PMID: 17825602); Br Dent J. 2004 Mar 27;196(6):329-33; quiz 362. (PMID: 15044984); JMIR Mhealth Uhealth. 2013 Dec 03;1(2):e25. (PMID: 25099436) |
| Entry Date(s): | Date Created: 20171128 Date Completed: 20171211 Latest Revision: 20260127 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC5703562 |
| DOI: | 10.1371/journal.pone.0188440 |
| PMID: | 29176904 |
| Database: | MEDLINE |
Journal Article