C-reactive protein as a marker of the surgical stress reduction within an ERAS protocol (Enhanced Recovery After Surgery) in colorectal surgery: A prospective cohort study.
| Title: | C-reactive protein as a marker of the surgical stress reduction within an ERAS protocol (Enhanced Recovery After Surgery) in colorectal surgery: A prospective cohort study. |
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| Authors: | Cabellos Olivares M; Department of Anesthesia, Hospital Universitario de Guadalajara, Guadalajara, Spain.; Labalde Martínez M; Department of Surgery, Hospital 12 de Octubre, Madrid, Spain.; Torralba M; Department of Internal Medical, Research Unit, Hospital Universitario de Guadalajara. Universidad de Alcalá, Guadalajara, Spain.; Rodríguez Fraile JR; Department of Anesthesia, Hospital Universitario de Guadalajara, Guadalajara, Spain.; Atance Martínez JC; Department of Health Inspection, Hospital Universitario de Guadalajara. Universidad de Alcalá, Guadalajara, Spain. |
| Source: | Journal of surgical oncology [J Surg Oncol] 2018 Mar; Vol. 117 (4), pp. 717-724. Date of Electronic Publication: 2018 Jan 22. |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: Wiley-Liss Country of Publication: United States NLM ID: 0222643 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-9098 (Electronic) Linking ISSN: 00224790 NLM ISO Abbreviation: J Surg Oncol Subsets: MEDLINE |
| Imprint Name(s): | Publication: : Hoboken, NJ : Wiley-Liss; Original Publication: New York, Plenum. |
| MeSH Terms: | C-Reactive Protein/*metabolism ; Gastrointestinal Diseases/*metabolism ; Gastrointestinal Diseases/*surgery; Biomarkers/metabolism ; Colectomy/adverse effects ; Colectomy/methods ; Colorectal Neoplasms/metabolism ; Colorectal Neoplasms/surgery ; Digestive System Surgical Procedures/methods ; Diverticular Diseases/metabolism ; Diverticular Diseases/surgery ; Inflammatory Bowel Diseases/metabolism ; Inflammatory Bowel Diseases/surgery ; Aged ; Cohort Studies ; Female ; Humans ; Male ; Prospective Studies ; Retrospective Studies |
| Abstract: | Background: The aim of this study is to evaluate the effectiveness of an Enhanced Recovery After Surgery Protocol (ERAS) in relation to reduce the Systemic Inflammatory Response (SIR) to surgery using C-reactive protein (CRP) in the first (POD1), second (POD2) and third (POD3) postoperative day.; Methods: We enrolled 121 patients (ERAS group) that underwent elective colorectal surgery with ERAS, and compared them with 135 patients (preERAS group) that had undergone surgery prior to the implementation. We made a univariate analysis to compare the CRP values in POD1, POD2, and POD3 between preERAS/ERAS group, laparoscopic/open surgery and the presence or not of Clavien Dindo complications. Multivariable lineal regression was used to assess if the ERAS had a decreasing effect on the CRP in POD1, POD2, and POD3, and was adjusted by age, male sex, use of laparoscopy, and complications.; Results: The presence of complications was independently associated with an increase in CRP values in POD1, POD2, and POD3. Laparoscopy in POD1 and POD2, and ERAS in POD2 was independently associated with a decrease in CRP values.; Conclusion: The analysis shows an increase in SIR measured as a CRP value in those patients that had complications. The SIR decreased with laparoscopy in POD1 and POD2 and with ERAS in POD2.; (© 2018 Wiley Periodicals, Inc.) |
| Contributed Indexing: | Keywords: C-reactive protein; colorectal surgery; enhanced recovery after surgery protocol; systemic inflammatory response |
| Substance Nomenclature: | 0 (Biomarkers); 9007-41-4 (C-Reactive Protein) |
| Entry Date(s): | Date Created: 20180123 Date Completed: 20180409 Latest Revision: 20180409 |
| Update Code: | 20260130 |
| DOI: | 10.1002/jso.24909 |
| PMID: | 29355975 |
| Database: | MEDLINE |
Journal Article