Prevalence of lower limb deep venous thrombosis among adult HIV positive patients attending an outpatient clinic at Mulago Hospital.
| Title: | Prevalence of lower limb deep venous thrombosis among adult HIV positive patients attending an outpatient clinic at Mulago Hospital. |
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| Authors: | Vululi ST; Makerere University College of Health Sciences (MakCHS), Kampala, Uganda. sosthenetsongo@gmail.com.; Bugeza S; Radiology Department of Mulago Hospital, Lecturer at MakCHS, Kampala, Uganda.; Zeridah M; Mulago Hospital, Kampala, Uganda.; Ddungu H; Uganda Cancer Institute, Kampala, Uganda.; Openy AB; MakCHS, Kampala, Uganda.; Frank M; Stastician-IDI-Kampala, Kampala, Uganda.; Parkes-Ratanshi R; Prevention Care Treatment, Infectious Diseases Institute (IDI), Kampala, Uganda. |
| Source: | AIDS research and therapy [AIDS Res Ther] 2018 Jan 25; Vol. 15 (1), pp. 3. Date of Electronic Publication: 2018 Jan 25. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Language: | English |
| Journal Info: | Publisher: BioMed Central Country of Publication: England NLM ID: 101237921 Publication Model: Electronic Cited Medium: Internet ISSN: 1742-6405 (Electronic) Linking ISSN: 17426405 NLM ISO Abbreviation: AIDS Res Ther Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: [London] : BioMed Central, 2004- |
| MeSH Terms: | Ambulatory Care Facilities*; HIV Infections/*complications ; HIV Infections/*epidemiology ; Lower Extremity/*pathology ; Venous Thrombosis/*complications ; Venous Thrombosis/*epidemiology; HIV Infections/drug therapy ; Lower Extremity/diagnostic imaging ; Uganda/epidemiology ; Venous Thrombosis/diagnosis ; Adult ; Antiretroviral Therapy, Highly Active ; Cross-Sectional Studies ; Female ; Hospitals ; Humans ; Male ; Middle Aged ; Odds Ratio ; Prevalence ; Risk Factors ; Ultrasonography ; Ultrasonography, Doppler ; Young Adult |
| Abstract: | Background: Deep venous thrombosis (DVT) and its major complication pulmonary embolism (PE) are collectively known as venous thromboembolism. In Uganda, the prevalence of DVT among HIV patients has not been previously published. The aim of the study was to determine the prevalence and sonographic features of lower limb deep venous thrombosis among HIV positive patients on anti-retroviral treatment (ART).; Methods: This was a cross sectional study in which HIV positive patients on ART were recruited from an out-patient HIV clinic at Mulago National Referral Hospital. Patients were randomly selected and enrolled until a sample size of 384 was reached. Study participants underwent compression and Doppler ultrasound studies of both lower limb deep veins using Medison Sonoacer7 ultrasound machine.; Resuts: We found a prevalence of DVT of 9.1% (35 of 384 participants) among HIV patients on ART. The prevalence of latent (asymptomatic) DVT was 2.3%. Among 35 patients with DVT, 42.8% had chronic DVT; 31.1% had acute DVT and the rest had latent DVT. Among the risk factors, the odds of occurrence of DVT among patients with prolonged immobility were 4.81 times as high as in those with no prolonged immobility (p = 0.023; OR = 4.81; 95% CI 1.25-18.62). Treatment with second line anti-retroviral therapy (ART) including protease inhibitors (PIs) was associated with higher odds of DVT occurrence compared with first line ART (p = 0.020; OR = 2.38; 95% CI 1.14-4.97). The odds of DVT occurrence in patients with a lower CD4 count ( |
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| Contributed Indexing: | Keywords: DVT echo pattern; Doppler ultrasound; Lower limb veins anatomy; Well’s score |
| Entry Date(s): | Date Created: 20180127 Date Completed: 20190918 Latest Revision: 20190918 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC5784710 |
| DOI: | 10.1186/s12981-018-0191-1 |
| PMID: | 29370816 |
| Database: | MEDLINE |
Journal Article; Research Support, Non-U.S. Gov't