Genetic polymorphisms associated with psoriasis and development of psoriatic arthritis in patients with psoriasis.
| Title: | Genetic polymorphisms associated with psoriasis and development of psoriatic arthritis in patients with psoriasis. |
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| Authors: | Loft ND; Department of Dermatology and Allergy, Herlev and Gentofte Hospital, University of Copenhagen, Hellerup, Denmark.; Skov L; Department of Dermatology and Allergy, Herlev and Gentofte Hospital, University of Copenhagen, Hellerup, Denmark.; Rasmussen MK; Department of Dermatology, Aarhus University Hospital, Aarhus, Denmark.; Gniadecki R; Department of Dermatology, Bispebjerg Hospital, Copenhagen, Denmark.; Dam TN; Dermatology Clinic, Nykoebing Falster, Denmark.; Brandslund I; Department of Clinical Immunology and Biochemistry, Lillebaelt Hospital, Vejle, Denmark.; Hoffmann HJ; Institute of Clinical Medicine, Aarhus University, and Department of Respiratory Diseases and Allergy B, Aarhus University Hospital, Aarhus, Denmark.; Andersen MR; Department of Clinical Biochemistry, Herlev and Gentofte Hospital, University of Copenhagen, Hellerup, Denmark.; Dessau RB; Department of Clinical Microbiology, Slagelse Hospital, Slagelse, Denmark.; Bergmann AC; Focused research unit for Molecular Diagnostic and Clinical Research, IRS-Center Soenderjylland, Hospital of Southern Jutland, Aabenraa, Denmark.; Andersen NM; Focused research unit for Molecular Diagnostic and Clinical Research, IRS-Center Soenderjylland, Hospital of Southern Jutland, Aabenraa, Denmark.; Abildtoft MK; Zitelab Aps, Copenhagen, Denmark.; Andersen PS; Department of Microbiology and Infection Control, Serum Institute, Copenhagen, Denmark.; Hetland ML; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; The DANBIO registry and Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Centre of Head and Orthopaedics, Rigshospitalet, Glostrup, Denmark.; Glintborg B; The DANBIO registry and Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Centre of Head and Orthopaedics, Rigshospitalet, Glostrup, Denmark.; Department of Rheumatology, Herlev and Gentofte Hospital, Hellerup, Denmark.; Bank S; Focused research unit for Molecular Diagnostic and Clinical Research, IRS-Center Soenderjylland, Hospital of Southern Jutland, Aabenraa, Denmark.; Vogel U; National Research Centre for the Working Environment, Copenhagen, Denmark.; Andersen V; Focused research unit for Molecular Diagnostic and Clinical Research, IRS-Center Soenderjylland, Hospital of Southern Jutland, Aabenraa, Denmark.; Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark.; OPEN (Odense Patient data Explorative Network), University of Southern Denmark, Odense, Denmark. |
| Source: | PloS one [PLoS One] 2018 Feb 01; Vol. 13 (2), pp. e0192010. Date of Electronic Publication: 2018 Feb 01 (Print Publication: 2018). |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Language: | English |
| Journal Info: | Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: San Francisco, CA : Public Library of Science |
| MeSH Terms: | Polymorphism, Single Nucleotide*; Arthritis, Psoriatic/*complications ; Psoriasis/*genetics; Psoriasis/complications ; Denmark ; Genetic Predisposition to Disease ; Humans |
| Abstract: | Background: Psoriasis (PsO) is a chronic inflammatory disease with predominantly cutaneous manifestations. Approximately one third of patients with PsO develop psoriatic arthritis (PsA), whereas the remaining proportion of patients has isolated cutaneous psoriasis (PsC). These two phenotypes share common immunology, but with different heredity that might in part be explained by genetic variables.; Methods: Using a candidate gene approach, we studied 53 single nucleotide polymorphisms (SNPs) in 37 genes that regulate inflammation. In total, we assessed 480 patients with PsO from DERMBIO, of whom 151 had PsC for 10 years or more (PsC10), 459 patients with PsA from DANBIO, and 795 healthy controls. Using logistic regression analysis, crude and adjusted for age and gender, we assessed associations between genetic variants and PsO, PsC10, and PsA, as well as associations between genetic variants and development of PsA in PsO.; Results: Eleven polymorphisms in 10 genes were nominally associated with PsO and/or PsC and/or PsA (P < 0.05). After correction for multiple testing with a false discovery rate of 5%, two SNPs remained significant: TNF (rs361525) was associated with PsO, PsC10, and PsA; and IL12B (rs6887695) was associated with PsO.; Conclusion: Among a cohort of Danish patients with moderate-to-severe psoriasis, two SNPs in the IL12B and TNF genes were associated with susceptibility of psoriasis. None of the SNPs were specifically associated with isolated cutaneous psoriasis or psoriatic arthritis. |
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| Entry Date(s): | Date Created: 20180202 Date Completed: 20180313 Latest Revision: 20260127 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC5794107 |
| DOI: | 10.1371/journal.pone.0192010 |
| PMID: | 29389950 |
| Database: | MEDLINE |
Journal Article; Research Support, Non-U.S. Gov't