Effect of Remote Ischemic Preconditioning on Troponin I in CABG.
| Title: | Effect of Remote Ischemic Preconditioning on Troponin I in CABG. |
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| Authors: | Javaherforoosh Zadeh F; Associate Professor of Anesthesia, Department of Anesthesia, Ahvaz Anesthesiology and Pain Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.; Moadeli M; Assistant Professor of Anesthesia, Department of Anesthesia, Ahvaz Anesthesiology and Pain Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.; Soltanzadeh M; Professor of Anesthesia, Department of Anesthesia, Ahvaz Anesthesiology and Pain Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.; Janatmakan F; Assistant Professor of Anesthesia, Department of Anesthesia, Ahvaz Anesthesiology and Pain Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. |
| Source: | Anesthesiology and pain medicine [Anesth Pain Med] 2017 Aug 21; Vol. 7 (4), pp. e12549. Date of Electronic Publication: 2017 Aug 21 (Print Publication: 2017). |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: Brieflands Country of Publication: Netherlands NLM ID: 101585412 Publication Model: eCollection Cited Medium: Print ISSN: 2228-7523 (Print) Linking ISSN: 22287523 NLM ISO Abbreviation: Anesth Pain Med Subsets: PubMed not MEDLINE |
| Imprint Name(s): | Publication: 's-Hertogenbosch, The Netherlands : Brieflands; Original Publication: Hoensbroek, Limburg : Kowsar Corp. |
| Abstract: | Background: Elective open heart surgery is associated with troponin release in some cases due to myocyte necrosis.; Objectives: The aim of this study was to measure cardiac troponin I (cTnI) preoperatively in elective CABG after remote ischemic preconditioning.; Methods: Twenty-eight patients were selected for elective CABG. They were randomized to receive remote ischemic preconditioning (induced by three 5-min cycles of inflation with a pneumatic tourniquet and 5-min deflation between inflation episodes as reperfusion).; Outcomes: Primary outcomes were cardiac troponin I levels at 6 and 24 hours after the procedure, and the secondary outcomes included creatine phosphokinase, lactate dehydrogenase, and serum creatinine levels. Hemodynamic changes were evaluated between the treatment and control groups.; Results: Cardiac troponin I at 6 hours after preconditioning was significantly lower compared to the control group (P = 0.036), and after 24 hours, there was still a significant difference between the two groups (P < 0.05).; Conclusions: Remote ischemic preconditioning reduces ischemic biomarkers during coronary artery bypass graft and attenuates procedure-related cardiac troponin I release and eventually reduces cardiovascular events such as myocardial infarction, chest pain, and hemodynamic changes after cardiac surgery. |
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| Contributed Indexing: | Keywords: Cardiac Outcomes; Cardiac Surgery; Remote Ischemic Preconditioning |
| Entry Date(s): | Date Created: 20180213 Latest Revision: 20220409 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC5797663 |
| DOI: | 10.5812/aapm.12549 |
| PMID: | 29430406 |
| Database: | MEDLINE |
Journal Article