Kaposi Varicelliform Eruption
| Title: | Kaposi Varicelliform Eruption |
|---|---|
| Authors: | Karray M; Rabta Hospital; Kwan E; Uniformed Services University of the Health Sciences; Souissi A |
| Source: | 2022 Jan. |
| Source: | In: StatPearls |
| Publication Type: | Study Guide |
| Language: | English |
| Journal Info: | Publisher: StatPearls Publishing Cited Medium: Internet |
| Imprint Name(s): | Treasure Island (FL) : StatPearls Publishing |
| Abstract: | Kaposi varicelliform eruption, also called eczema herpeticum, refers to a disseminated skin infection due to a virus that usually leads to localized vesicular eruptions, occurring in a patient with an underlying cutaneous disease. Although rare, it is potentially life-threatening disorder. Herpes simplex virus is considered the main causative agent. The most commonly reported cases occur in patients with atopic dermatitis. However, it has been described in association with other skin conditions such as pemphigus foliaceus, ichthyosis vulgaris, bullous pemphigoid, Darier disease, Grover disease, Hailey-Hailey disease, dyskeratosis follicularis, mycosis fungoides, Sezary syndrome, psoriasis, pityriasis rubra pilaris, rosacea, seborrheic dermatitis, contact dermatitis (both allergic and irritant), second degree burns and skin grafts. Clinical features of Kaposi varicelliform eruption include widespread clusters of umbilicated vesicles and pustules that evolve into crusted skin erosions. The most frequently affected sites are the trunk, neck, and head. The diagnosis of Kaposi varicelliform eruption is made primarily on clinical findings. The Tzanck smear, viral cultures, skin biopsy, or detection of viral DNA by Polymerase Chain Reaction may be helpful in doubtful cases. Antiviral therapy has been effective but should be started as soon as possible after diagnosis to reduce morbidity and mortality.; (Copyright © 2022, StatPearls Publishing LLC.) |
| References: | Skrek SV, Timoshchuk EA, Sidikov AA, Zaslavsky DV, Megna M. Kaposi varicelliform eruption induced by methotrexate in an adult atopic dermatitis patient. Dermatol Ther. 2019 Mar;32(2):e12826. (PMID: 30659717); Miller DM, Trowbridge RM, Desai A, Drews RE. Kaposi's varicelliform eruption in a patient with metastatic melanoma and primary cutaneous anaplastic large cell lymphoma treated with talimogene laherparepvec and nivolumab. J Immunother Cancer. 2018 Nov 19;6(1):122. (PMID: PMC624580930454071); Gottesman SP, Rosen JR, Geller JD, Freeman BB. Atypical Varicella-Zoster Kaposi Varicelliform Eruption in Sézary Syndrome. Am J Dermatopathol. 2018 Dec;40(12):920-923. (PMID: 30211729); Azmi M, Nasim A, Dodani S, Laiq SM, Mehdi SH, Mubarak M. Kaposi Varicelliform Eruption Associated With Chickenpox in a Liver Transplant Recipient. Exp Clin Transplant. 2020 Apr;18(2):252-254. (PMID: 29957162); Gruhl RR, Wu A, Niermann M, Olson A. Not all that vesicles is herpes. Diagnosis (Berl) 2017 Nov 27;4(4):261-264. (PMID: 29536938); Okamoto M, Takahagi S, Tanaka A, Ogawa A, Nobuki H, Hide M. A case of Kaposi varicelliform eruption progressing to herpes simplex virus hepatitis in an immunocompetent patient. Clin Exp Dermatol. 2018 Jul;43(5):636-638. (PMID: 29446473); Sato E, Hiromatsu K, Murata K, Imafuku S. Loss of ATP2A2 Allows Herpes Simplex Virus 1 Infection of a Human Epidermis Model by Disrupting Innate Immunity and Barrier Function. J Invest Dermatol. 2018 Dec;138(12):2540-2549. (PMID: 29870688); Sun D, Ong PY. Infectious Complications in Atopic Dermatitis. Immunol Allergy Clin North Am. 2017 Feb;37(1):75-93. (PMID: 27886912); Lehman JS, el-Azhary RA. Kaposi varicelliform eruption in patients with autoimmune bullous dermatoses. Int J Dermatol. 2016 Mar;55(3):e136-40. (PMID: 26500144); Lyons JJ, Milner JD, Stone KD. Atopic dermatitis in children: clinical features, pathophysiology, and treatment. Immunol Allergy Clin North Am. 2015 Feb;35(1):161-83. (PMID: PMC425456925459583); Wollenberg A, Seba A, Antal AS. Immunological and molecular targets of atopic dermatitis treatment. Br J Dermatol. 2014 Jul;170 Suppl 1:7-11. (PMID: 24720588); Reed JL, Scott DE, Bray M. Eczema vaccinatum. Clin Infect Dis. 2012 Mar;54(6):832-40. (PMID: 22291103); Sohail M, Khan FA, Shami HB, Bashir MM. Management of eczema herpeticum in a Burn Unit. J Pak Med Assoc. 2016 Nov;66(11):1357-1361. (PMID: 27812048) |
| Entry Date(s): | Date Created: 20220912 |
| Update Code: | 20221215 |
| PMID: | 29494039 |
| Book AN: | NBK482432 |
| Database: | MEDLINE |
Study Guide