The impact of oral food challenges for food allergy on quality of life: A systematic review.
| Title: | The impact of oral food challenges for food allergy on quality of life: A systematic review. |
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| Authors: | Kansen HM; Department of Pediatric Pulmonology and Allergology, Wilhelmina Children's Hospital, University Medical Centre Utrecht, Utrecht, The Netherlands.; Le TM; Department of Dermatology, University Medical Centre Utrecht, Utrecht, The Netherlands.; Meijer Y; Department of Pediatric Pulmonology and Allergology, Wilhelmina Children's Hospital, University Medical Centre Utrecht, Utrecht, The Netherlands.; Flokstra-de Blok BMJ; GRIAC Research Institute, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.; Department of General Practice and Elderly Care Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.; Welsing PMJ; Department of Dermatology, University Medical Centre Utrecht, Utrecht, The Netherlands.; van der Ent CK; Department of Pediatric Pulmonology and Allergology, Wilhelmina Children's Hospital, University Medical Centre Utrecht, Utrecht, The Netherlands.; Knulst AC; Department of Dermatology, University Medical Centre Utrecht, Utrecht, The Netherlands.; van Erp FC; Department of Dermatology, University Medical Centre Utrecht, Utrecht, The Netherlands. |
| Source: | Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology [Pediatr Allergy Immunol] 2018 Aug; Vol. 29 (5), pp. 527-537. Date of Electronic Publication: 2018 May 16. |
| Publication Type: | Journal Article; Systematic Review |
| Language: | English |
| Journal Info: | Publisher: Blackwell Publishing Country of Publication: England NLM ID: 9106718 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1399-3038 (Electronic) Linking ISSN: 09056157 NLM ISO Abbreviation: Pediatr Allergy Immunol Subsets: MEDLINE |
| Imprint Name(s): | Publication: : Oxford, UK : Blackwell Publishing; Original Publication: Copenhagen : Munksgaard, c1990- |
| MeSH Terms: | Allergens/*immunology ; Anaphylaxis/*prevention & control ; Food Hypersensitivity/*diagnosis; Anaphylaxis/epidemiology ; Anaphylaxis/etiology ; Food Hypersensitivity/complications ; Food Hypersensitivity/epidemiology ; Immunization/adverse effects ; Administration, Oral ; Animals ; Food ; Humans ; Quality of Life ; Surveys and Questionnaires |
| Abstract: | Background: Food allergy significantly impairs health-related quality of life (HRQL). Currently, it is still unknown whether diagnostic interventions for food allergy improve HRQL. We aim to assess the impact of diagnostic interventions for food allergy on HRQL.; Methods: A systematic search was performed in MEDLINE, Embase, Cochrane Library, and CINAHL focused on patients with a (suspected) food allergy who underwent diagnostic interventions (ie, skin prick test, specific IgE, or oral food challenges [OFC]) and in whom HRQL was assessed. The mean difference between HRQL before and after the diagnostic intervention was calculated. A minimal clinically important difference of 0.5 was considered clinically relevant for the food allergy quality of life questionnaire.; Results: Seven of 1465 original identified publications were included in which the impact of an OFC on HRQL was investigated (total patients n = 1370). No other diagnostic interventions were investigated. Food allergy-specific parent-reported HRQL improved significantly after an OFC irrespective of the outcome in children with a suspected food allergy in two publications. The change was considered clinically relevant in one of two publications. In addition, parent-reported HRQL improved after an OFC to assess the eliciting dose in children with a confirmed food allergy. The parental burden was significantly reduced after an OFC to assess resolution of food allergy. A meta-analysis could not be performed due to the limited numbers of, and considerable heterogeneity between, eligible publications.; Conclusion: An OFC is associated with an improved food allergy-specific HRQL and a reduced parental burden of food allergy.; (© 2018 The Authors. Pediatric Allergy and Immunology Published by John Wiley & Sons Ltd.) |
| Contributed Indexing: | Keywords: challenge tests; clinical aspects; diagnostic techniques; food challenge; quality of life |
| Substance Nomenclature: | 0 (Allergens) |
| Entry Date(s): | Date Created: 20180417 Date Completed: 20190111 Latest Revision: 20190417 |
| Update Code: | 20260130 |
| DOI: | 10.1111/pai.12905 |
| PMID: | 29660855 |
| Database: | MEDLINE |
Journal Article; Systematic Review