Biobanking in a Challenging African Environment: Unique Experience from the SIREN Project.
| Title: | Biobanking in a Challenging African Environment: Unique Experience from the SIREN Project. |
|---|---|
| Authors: | Akinyemi RO; Center for Genomic and Precision Medicine, College of Medicine, University of Ibadan, Ibadan, Nigeria.; Neuroscience and Ageing Research Unit, Institute for Advanced Medical Research and Training, College of Medicine, University of Ibadan, Ibadan, Nigeria.; Pathology Department, Federal Medical Centre, Abeokuta, Nigeria.; Neurology Unit, Department of Medicine, College of Medicine, University of Ibadan, Nigeria.; Akinwande K; Pathology Department, Federal Medical Centre, Abeokuta, Nigeria.; Diala S; Center for Genomic and Precision Medicine, College of Medicine, University of Ibadan, Ibadan, Nigeria.; Neurology Unit, Department of Medicine, College of Medicine, University of Ibadan, Nigeria.; Adeleye O; Pathology Department, Federal Medical Centre, Abeokuta, Nigeria.; Ajose A; Neurology Unit, Department of Medicine, Obafemi Awolowo University Teaching Hospital, Ile-Ife, Nigeria.; Issa K; Center for Genomic and Precision Medicine, College of Medicine, University of Ibadan, Ibadan, Nigeria.; Neurology Unit, Department of Medicine, College of Medicine, University of Ibadan, Nigeria.; Owusu D; Neurology Unit, Department of Medicine, Kwame Nkrumah University of Science & Technology, Kumasi, Ghana.; Boamah I; Neurology Unit, Department of Medicine, School of Medicine & Dentistry, College of Health Sciences, University of Ghana, Accra, Ghana.; Yahaya IS; Neurology Unit, Department of Medicine, Bayero University, Kano, Nigeria.; Jimoh AO; Neurology Unit, Department of Medicine, University of Ilorin Teaching Hospital, Ilorin, Nigeria.; Imoh L; Neurology Unit, Department of Medicine, Jos University Teaching Hospital, Jos, Nigeria.; Fakunle G; Center for Genomic and Precision Medicine, College of Medicine, University of Ibadan, Ibadan, Nigeria.; Neurology Unit, Department of Medicine, College of Medicine, University of Ibadan, Nigeria.; Akpalu A; Neurology Unit, Department of Medicine, School of Medicine & Dentistry, College of Health Sciences, University of Ghana, Accra, Ghana.; Sarfo F; Neurology Unit, Department of Medicine, Kwame Nkrumah University of Science & Technology, Kumasi, Ghana.; Wahab K; Neurology Unit, Department of Medicine, University of Ilorin Teaching Hospital, Ilorin, Nigeria.; Sanya E; Neurology Unit, Department of Medicine, University of Ilorin Teaching Hospital, Ilorin, Nigeria.; Owolabi L; Neurology Unit, Department of Medicine, Bayero University, Kano, Nigeria.; Obiako R; Neurology Unit, Department of Medicine, Ahmadu Bello University Teaching Hospital, Zaria, Nigeria.; Osaigbovo G; Neurology Unit, Department of Medicine, Jos University Teaching Hospital, Jos, Nigeria.; Komolafe M; Neurology Unit, Department of Medicine, Obafemi Awolowo University Teaching Hospital, Ile-Ife, Nigeria.; Fawale M; Neurology Unit, Department of Medicine, Obafemi Awolowo University Teaching Hospital, Ile-Ife, Nigeria.; Adebayo P; Neurology Unit, Department of Medicine, Ladoke Akintola University Teaching Hospital, Ogbomoso, Nigeria.; Olowoyo P; Neurology Unit, Department of Medicine, Federal University Teaching Hospital, Ido Ekiti, Nigeria.; Obiabo Y; Neurology Unit, Department of Medicine, Delta State University Teaching Hospital, Igharra, Nigeria.; Sunmonu T; Neurology Unit, Department of Medicine, Federal Medical Center, Owo, Nigeria.; Chukwuonye I; Neurology Unit, Department of Medicine, Federal Medical Center, Umuahia, Nigeria.; Balogun O; Neurology Unit, Department of Medicine, Ahmadu Bello University Teaching Hospital, Zaria, Nigeria.; Adeoye B; Center for Genomic and Precision Medicine, College of Medicine, University of Ibadan, Ibadan, Nigeria.; Neurology Unit, Department of Medicine, College of Medicine, University of Ibadan, Nigeria.; Oladele F; Center for Genomic and Precision Medicine, College of Medicine, University of Ibadan, Ibadan, Nigeria.; Neurology Unit, Department of Medicine, College of Medicine, University of Ibadan, Nigeria.; Olowoniyi P; Neurology Unit, Department of Medicine, Federal Medical Center, Umuahia, Nigeria.; Adeyemi F; Neurology Unit, Department of Medicine, Federal Medical Center, Owo, Nigeria.; Lezzi A; Neurology Unit, Department of Medicine, Delta State University Teaching Hospital, Igharra, Nigeria.; Falayi AT; Neurology Unit, Department of Medicine, Federal University Teaching Hospital, Ido Ekiti, Nigeria.; Fasanya M; Neurology Unit, Department of Medicine, Obafemi Awolowo University Teaching Hospital, Ile-Ife, Nigeria.; Ogunwale K; Neurology Unit, Department of Medicine, University of Ilorin Teaching Hospital, Ilorin, Nigeria.; Adeola O; Pathology Department, Federal Medical Centre, Abeokuta, Nigeria.; Olomu O; Neurology Unit, Department of Medicine, College of Medicine, University of Ibadan, Nigeria.; Aridegbe O; Pathology Department, Federal Medical Centre, Abeokuta, Nigeria.; Laryea R; Neurology Unit, Department of Medicine, School of Medicine & Dentistry, College of Health Sciences, University of Ghana, Accra, Ghana.; Uvere E; Center for Genomic and Precision Medicine, College of Medicine, University of Ibadan, Ibadan, Nigeria.; Neurology Unit, Department of Medicine, College of Medicine, University of Ibadan, Nigeria.; Faniyan M; Center for Genomic and Precision Medicine, College of Medicine, University of Ibadan, Ibadan, Nigeria.; Neurology Unit, Department of Medicine, College of Medicine, University of Ibadan, Nigeria.; Melikam E; Center for Genomic and Precision Medicine, College of Medicine, University of Ibadan, Ibadan, Nigeria.; Neurology Unit, Department of Medicine, College of Medicine, University of Ibadan, Nigeria.; Tagge R; Department of Neurosciences, Medical University of South Carolina, Charleston, South Carolina.; Akpa O; Center for Genomic and Precision Medicine, College of Medicine, University of Ibadan, Ibadan, Nigeria.; Akinyemi J; Center for Genomic and Precision Medicine, College of Medicine, University of Ibadan, Ibadan, Nigeria.; Arulogun O; Center for Genomic and Precision Medicine, College of Medicine, University of Ibadan, Ibadan, Nigeria.; Tiwari HK; School of Public Health, University of Alabama, Birmingham, Alabama.; Ovbiagele B; Department of Neurosciences, Medical University of South Carolina, Charleston, South Carolina.; Owolabi MO; Center for Genomic and Precision Medicine, College of Medicine, University of Ibadan, Ibadan, Nigeria.; Neurology Unit, Department of Medicine, College of Medicine, University of Ibadan, Nigeria. |
| Source: | Biopreservation and biobanking [Biopreserv Biobank] 2018 Jun; Vol. 16 (3), pp. 217-232. Date of Electronic Publication: 2018 May 07. |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: Mary Ann Liebert Country of Publication: United States NLM ID: 101507284 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1947-5543 (Electronic) Linking ISSN: 19475543 NLM ISO Abbreviation: Biopreserv Biobank Subsets: MEDLINE; PubMed not MEDLINE |
| Imprint Name(s): | Original Publication: New Rochelle, NY : Mary Ann Liebert |
| Abstract: | Africa was previously insufficiently represented in the emerging discipline of biobanking despite commendable early efforts. However, with the Human, Heredity, and Health in Africa (H3Africa) initiative, biorepository science has been bolstered, regional biobanks are springing up, and awareness about biobanks is growing on the continent. The Stroke Investigative Research and Educational Network (SIREN) project is a transnational, multicenter, hospital and community-based study involving over 3000 cases and 3000 controls recruited from 16 sites in Ghana and Nigeria. SIREN aims to explore and unravel the genetic and environmental factors that interact to produce the peculiar phenotypic and clinical characteristics of stroke as seen in people of African ancestry and facilitate the development of new diagnostics, therapeutics, and preventative strategies. The aim of this article is to describe our experience with the development of the procedure for collection, processing, storage, and shipment of biological samples (blood, serum, plasma, buffy coat, red cell concentrates, and DNA) and brain imaging across coordinating and participating sites within the SIREN Project. The SIREN network was initiated in 2014 with support and funding from the H3Africa Initiative. The SIREN Biobank currently has 3015 brain images, 92,950 blood fractions (serum, plasma, red cell concentrates, and buffy coat) accrued from 8450 recruited subjects, and quantified and aliquoted good-quality DNA extracts from 6150 study subjects. This represents an invaluable resource for future research with expanding genomic and trans-omic technologies. This will facilitate the involvement of indigenous African samples in cutting-edge stroke genomics and trans-omics research. It is, however, critical to effectively engage African stroke patients and community members who have contributed precious biological materials to the SIREN Biobank to generate appropriate evidence base for dealing with ethical, legal, and social issues of privacy, autonomy, identifiability, biorights, governance issues, and public understanding of stroke biobanking in the context of unique African culture, language, and belief systems. |
| References: | J Biomed Inform. 2009 Apr;42(2):377-81. (PMID: 18929686); Stroke. 2015 Jan;46(1):279-84. (PMID: 25492903); Curr Opin Genet Dev. 2016 Dec;41:77-84. (PMID: 27644073); Lipids. 1978 Dec;13(12):926-32. (PMID: 220488); Glob Heart. 2017 Jun;12(2):163-168. (PMID: 28336388); S Afr Med J. 2016 Aug 02;106(9):867-9. (PMID: 27601106); Science. 2014 Jun 20;344(6190):1346-8. (PMID: 24948725); Recent Pat DNA Gene Seq. 2011 Apr;5(1):1-7. (PMID: 21303346); Clin Chem. 1974 Apr;20(4):470-5. (PMID: 4818200); Stroke. 2015 Jan;46(1):285-90. (PMID: 25492904); JAMA. 2001 May 16;285(19):2486-97. (PMID: 11368702); Neurol Genet. 2017 Mar 15;3(2):e142. (PMID: 28349126); Cancer Epidemiol Biomarkers Prev. 2010 Apr;19(4):1012-5. (PMID: 20332272); J Stroke Cerebrovasc Dis. 2017 Nov;26(11):2662-2670. (PMID: 28760409); Cardiovasc J Afr. 2015 Mar-Apr;26(2 Suppl 1):S27-38. (PMID: 25962945); Biopreserv Biobank. 2012 Apr;10(2):79-161. (PMID: 24844904); N Engl J Med. 2015 Feb 26;372(9):793-5. (PMID: 25635347); J Neurol Sci. 2017 Jan 15;372:262-269. (PMID: 28017225); Cardiovasc J Afr. 2015 Mar-Apr;26(2 Suppl 1):S39-49. (PMID: 25962947); Curr Opin Oncol. 2011 Jan;23(1):112-9. (PMID: 21076300); Biopreserv Biobank. 2012 Apr;10(2):232-3. (PMID: 24844910); Clin Chem. 1997 Nov;43(11):2183-4. (PMID: 9365406); Clin Chem. 1984 May;30(5):813-4. (PMID: 6713653); J Neurol Sci. 2016 Jul 15;366:213-223. (PMID: 27288810); Nature. 2008 Dec 11;456(7223):732-7. (PMID: 19079050); Annu Rev Pharmacol Toxicol. 2016;56:211-28. (PMID: 26514206); J Neurol Sci. 2017 Nov 15;382:18-28. (PMID: 29111012); Biopreserv Biobank. 2016 Oct;14(5):355-356. (PMID: 27622547); Pathobiology. 2014;81(5-6):252-260. (PMID: 25792214); Neuroepidemiology. 2015;45(2):73-82. (PMID: 26304844); Ann Clin Lab Sci. 1983 Nov-Dec;13(6):482-8. (PMID: 6660832); Biopreserv Biobank. 2017 Apr;15(2):142-147. (PMID: 28375760) |
| Contributed Indexing: | Keywords: Africa; Low and Middle Income Countries (LMIC); biobanking; genomics; neurological disorders; stroke; trans-omics |
| Entry Date(s): | Date Created: 20180508 Latest Revision: 20241108 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC5995267 |
| DOI: | 10.1089/bio.2017.0113 |
| PMID: | 29733683 |
| Database: | MEDLINE |
Journal Article