Multi-ethnic genome-wide association study for atrial fibrillation.
| Title: | Multi-ethnic genome-wide association study for atrial fibrillation. |
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| Authors: | Roselli C; Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Chaffin MD; Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Weng LC; Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.; Aeschbacher S; University Hospital Basel, Basel, Switzerland.; Cardiovascular Research Institute Basel, Basel, Switzerland.; Ahlberg G; Laboratory for Molecular Cardiology, The Heart Centre, Department of Cardiology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.; The Danish National Research Foundation Centre for Cardiac Arrhythmia, Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Albert CM; Divisions of Preventive and Cardiovascular Medicine, Brigham and Women's Hospital & Harvard Medical School, Boston, MA, USA.; Almgren P; Department of Clinical Sciences, Lund University, Malmo, Sweden.; Alonso A; Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA.; Anderson CD; Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Aragam KG; Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Arking DE; McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Barnard J; Departments of Cardiovascular Medicine, Cellular and Molecular Medicine, Molecular Cardiology, and Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH, USA.; Bartz TM; Cardiovascular Health Research Unit, Departments of Medicine and Biostatistics, University of Washington, Seattle, WA, USA.; Benjamin EJ; NHLBI and Boston University's Framingham Heart Study, Framingham, MA, USA.; Department of Medicine, Boston University School of Medicine, Boston, MA, USA.; Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA.; Bihlmeyer NA; Predoctoral Training Program in Human Genetics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Bis JC; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.; Bloom HL; Division of Cardiology, Emory University and Atlanta VA Medical Center, Atlanta, GA, USA.; Boerwinkle E; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA.; Bottinger EB; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Brody JA; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.; Calkins H; Johns Hopkins University, Baltimore, MD, USA.; Campbell A; Generation Scotland, Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.; Cappola TP; Penn Cardiovascular Institute and Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Carlquist J; Intermountain Heart Institute, Intermountain Medical Center, Murray, UT, USA.; Division of Cardiovascular Medicine, University of Utah, Salt Lake City, UT, USA.; Chasman DI; Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Divisions of Preventive Medicine and Genetics, Brigham and Women's Hospital & Harvard Medical School, Boston, MA, USA.; Chen LY; Cardiovascular Division, Department of Medicine, University of Minnesota Medical School, Minneapolis, MN, USA.; Chen YI; Institute for Translational Genomics and Population Sciences, Department of Pediatrics, LABioMed at Harbor-UCLA Medical Center, Torrance, CA, USA.; Choi EK; Seoul National University Hospital, Seoul, Korea.; Choi SH; Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Christophersen IE; Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.; Department of Medical Research, Bærum Hospital, Vestre Viken Hospital Trust, Drammen, Norway.; Chung MK; Departments of Cardiovascular Medicine, Cellular and Molecular Medicine, Molecular Cardiology, and Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH, USA.; Cole JW; Baltimore Veterans Affairs Medical Center, Department of Neurology, Baltimore, MD, USA.; University of Maryland School of Medicine, Department of Neurology, Baltimore, MD, USA.; Conen D; University Hospital Basel, Basel, Switzerland.; Cardiovascular Research Institute Basel, Basel, Switzerland.; Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada.; Cook J; Department of Biostatistics, University of Liverpool, Liverpool, UK.; Crijns HJ; Maastricht University Medical Center+ and Cardiovascular Research Institute Maastricht, Department of Cardiology, Maastricht, The Netherlands.; Cutler MJ; Intermountain Heart Institute, Intermountain Medical Center, Murray, UT, USA.; Damrauer SM; Department of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Department of Surgery, Corporal Michael Crescenz VA Medical Center, Philadelphia, PA, USA.; Daniels BR; Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Darbar D; University of Illinois Chicago, Chicago, IL, USA.; Delgado G; Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany.; Denny JC; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; Dichgans M; Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.; Dörr M; Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany.; DZHK (German Centre for Cardiovascular Research), partner site: Greifswald, Greifswald, Germany.; Dudink EA; Maastricht University Medical Center+ and Cardiovascular Research Institute Maastricht, Department of Cardiology, Maastricht, The Netherlands.; Dudley SC; Cardiovascular Division and Lillehei Heart Institute, University of Minnesota, Minneapolis, MN, USA.; Esa N; University of Massachusetts Medical School Worcester, Worcester, MA, USA.; Esko T; Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Estonian Genome Center, University of Tartu, Tartu, Estonia.; Eskola M; Heart Center, Department of Cardiology, Tampere University Hospital, Finland and Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland.; Fatkin D; Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales, Australia.; St Vincent's Hospital, Darlinghurst, New South Wales, Australia.; Faculty of Medicine, University of New South Wales, Kensington, New South Wales, Australia.; Felix SB; Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany.; DZHK (German Centre for Cardiovascular Research), partner site: Greifswald, Greifswald, Germany.; Ford I; Robertson Center for Biostatistics, University of Glasgow, Glasgow, UK.; Franco OH; Department of Epidemiology, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands.; Geelhoed B; Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.; Grewal RP; Dept. of Neuroscience, Saint Francis Medical Center, Trenton, NJ, USA.; School of Health and Medical Sciences, Seton Hall University, South Orange, NJ, USA.; Gudnason V; Icelandic Heart Association, Kopavogur, Iceland.; Faculty of Medicine, University of Iceland, Reykavik, Iceland.; Guo X; Institute for Translational Genomics and Population Sciences, Department of Pediatrics, LABioMed at Harbor-UCLA Medical Center, Torrance, CA, USA.; Gupta N; Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Gustafsson S; Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.; Gutmann R; Division of Cardiovascular Medicine and Abboud Cardiovascular Research Center, University of Iowa, Iowa City, IA, USA.; Hamsten A; Cardiovascular Genetics and Genomics Group, Atherosclerosis Research Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.; Harris TB; Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Bethesda, MD, USA.; Hayward C; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.; Heckbert SR; Cardiovascular Health Research Unit and Department of Epidemiology, University of Washington, Seattle, WA, USA.; Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA.; Hernesniemi J; Heart Center, Department of Cardiology, Tampere University Hospital, Finland and Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland.; Department of Clinical Chemistry, Fimlab Laboratories and Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland.; Hocking LJ; Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK.; Hofman A; Department of Epidemiology, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands.; Horimoto ARVR; Laboratory of Genetics and Molecular Cardiology, Heart Institute, University of São Paulo, São Paulo, Brazil.; Huang J; Boston VA Research Institute, Inc., Boston, MA, USA.; Huang PL; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.; Huffman J; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.; Ingelsson E; Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.; Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.; Ipek EG; Johns Hopkins University, Baltimore, MD, USA.; Ito K; Laboratory for Cardiovascular Diseases, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.; Jimenez-Conde J; Department of Neurology, Neurovascular Research Group IMIM-Hospital del Mar (Institut Hospital del Mar d'Investigacions Médiques), Barcelona, Spain.; Universitat Autònoma de Barcelona, Medicine Department, Barcelona, Spain.; Johnson R; Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales, Australia.; Jukema JW; Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.; Durrer Center for Cardiogenetic Research, Amsterdam, The Netherlands.; Interuniversity Cardiology Institute of the Netherlands, Utrecht, The Netherlands.; Kääb S; Department of Medicine I, University Hospital Munich, Ludwig-Maximilians-University, Munich, Germany.; DZHK (German Centre for Cardiovascular Research), partner site: Munich Heart Alliance, Munich, Germany.; Kähönen M; Department of Clinical Physiology, Tampere University Hospital, and Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland.; Kamatani Y; Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.; Kane JP; Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA, USA.; Kastrati A; DZHK (German Centre for Cardiovascular Research), partner site: Munich Heart Alliance, Munich, Germany.; Deutsches Herzzentrum München, Klinik für Herz- und Kreislauferkrankungen, Technische Universität München, Munich, Germany.; Kathiresan S; Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Katschnig-Winter P; Department of Neurology, Medical University of Graz, Graz, Austria.; Kavousi M; Department of Epidemiology, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands.; Kessler T; Deutsches Herzzentrum München, Klinik für Herz- und Kreislauferkrankungen, Technische Universität München, Munich, Germany.; Kietselaer BL; Maastricht University Medical Center+ and Cardiovascular Research Institute Maastricht, Department of Cardiology, Maastricht, The Netherlands.; Kirchhof P; Institute of Cardiovascular Sciences, University of Birmingham, Birmingham, UK.; Sandwell and West Birmingham Hospitals NHS Trust and University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.; AFNET, Muenster, Germany.; Kleber ME; Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany.; Knight S; Intermountain Heart Institute, Intermountain Medical Center, Murray, UT, USA.; Department of Medicine, University of Utah, Salt Lake City, UT, USA.; Krieger JE; Laboratory of Genetics and Molecular Cardiology, Heart Institute, University of São Paulo, São Paulo, Brazil.; Kubo M; RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.; Launer LJ; Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Bethesda, MD, USA.; Laurikka J; Department of Cardio-Thoracic Surgery, Heart Center, Tampere University Hospital, and Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland.; Lehtimäki T; Department of Clinical Chemistry, Fimlab Laboratories and Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland.; Leineweber K; Dept. Disease Genomics, Bayer, Wuppertal, Germany.; Lemaitre RN; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.; Li M; Department of Epidemiology, Johns Hopkins University, Baltimore, MD, USA.; Division of Nephrology & Hypertension, Internal Medicine, School of Medicine, University of Utah, Salt Lake City, UT, USA.; Lim HE; Korea University Guro Hospital, Seoul, Korea.; Lin HJ; Institute for Translational Genomics and Population Sciences, Department of Pediatrics, LABioMed at Harbor-UCLA Medical Center, Torrance, CA, USA.; Lin H; NHLBI and Boston University's Framingham Heart Study, Framingham, MA, USA.; Department of Medicine, Boston University School of Medicine, Boston, MA, USA.; Lind L; Department of Medical Sciences, Cardiovascular Epidemiology, Uppsala University, Uppsala, Sweden.; Lindgren CM; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.; Lokki ML; Transplantation Laboratory, Medicum, University of Helsinki, Helsinki, Finland.; London B; Division of Cardiovascular Medicine and Abboud Cardiovascular Research Center, University of Iowa, Iowa City, IA, USA.; Loos RJF; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Genetics of Obesity and Related Metabolic Traits Program, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Low SK; Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.; Lu Y; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Genetics of Obesity and Related Metabolic Traits Program, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Lyytikäinen LP; Department of Clinical Chemistry, Fimlab Laboratories and Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland.; Macfarlane PW; Institute of Health and Wellbeing, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.; Magnusson PK; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.; Mahajan A; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.; Malik R; Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany.; Mansur AJ; Heart Institute, University of São Paulo, São Paulo, Brazil.; Marcus GM; Division of Cardiology, University of California, San Francisco, San Francisco, California, USA.; Margolin L; Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Margulies KB; Penn Cardiovascular Institute and Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; März W; Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria.; Synlab Academy, Synlab Services GmbH, Mannheim, Germany.; McManus DD; University of Massachusetts Medical School Worcester, Worcester, MA, USA.; Melander O; Department of Internal Medicine, Clinical Sciences, Lund University, Malmo, Sweden.; Mohanty S; Texas Cardiac Arrhythmia Institute, St David's Medical Center, Austin, TX, USA.; Dell Medical School, Austin, TX, USA.; Montgomery JA; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; Morley MP; Penn Cardiovascular Institute and Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Morris AP; Department of Biostatistics, University of Liverpool, Liverpool, UK.; Müller-Nurasyid M; Department of Medicine I, University Hospital Munich, Ludwig-Maximilians-University, Munich, Germany.; DZHK (German Centre for Cardiovascular Research), partner site: Munich Heart Alliance, Munich, Germany.; Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.; Natale A; Texas Cardiac Arrhythmia Institute, St David's Medical Center, Austin, TX, USA.; Dell Medical School, Austin, TX, USA.; Nazarian S; University of Pennsylvania, Philadelphia, PA, USA.; Neumann B; Department of Medicine I, University Hospital Munich, Ludwig-Maximilians-University, Munich, Germany.; Newton-Cheh C; Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Niemeijer MN; Department of Epidemiology, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands.; Nikus K; Heart Center, Department of Cardiology, Tampere University Hospital, Finland and Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland.; Nilsson P; Department of Clinical Sciences, Lund University and Skåne University Hospital, Malmo, Sweden.; Noordam R; Section of Gerontology and Geriatrics, Department of Internal Medicine, Leiden University Medical Center, Leiden, The Netherlands.; Oellers H; Atrial Fibrillation NETwork, Muenster, Germany.; Olesen MS; Laboratory for Molecular Cardiology, The Heart Centre, Department of Cardiology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.; The Danish National Research Foundation Centre for Cardiac Arrhythmia, Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Orho-Melander M; Department of Clinical Sciences, Lund University, Malmo, Sweden.; Padmanabhan S; Institute of Cardiovascular and Medical Sciences, BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, UK.; Pak HN; Yonsei University Health System, Seoul, Korea.; Paré G; Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada.; Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.; Pedersen NL; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.; Pera J; Department of Neurology, Faculty of Medicine, Jagiellonian University Medical College, Krakow, Poland.; Pereira A; Laboratory of Genetics and Molecular Biology, Heart Institute, University of São Paulo, São Paulo, Brazil.; Department of Genetics, Harvard Medical School, Boston, MA, USA.; Porteous D; Generation Scotland, Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.; Psaty BM; Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA.; Cardiovascular Health Research Unit, Departments of Medicine, Epidemiology, and Health Services, University of Washington, Seattle, WA, USA.; Pulit SL; Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Genetics, Center for Molecular Medicine, University Medical Centre Utrecht, Utrecht University, Utrecht, The Netherlands.; Li Ka Shing Center for Health Information and Discovery, Big Data Institute, Oxford University, Oxford, UK.; Pullinger CR; Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA, USA.; Rader DJ; Division of Cardiovascular Medicine, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.; Refsgaard L; Laboratory for Molecular Cardiology, The Heart Centre, Department of Cardiology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.; The Danish National Research Foundation Centre for Cardiac Arrhythmia, Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Ribasés M; Psychiatric Genetics Unit, Group of Psychiatry, Mental Health and Addiction, Vall d'Hebron Research Institute (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain.; Department of Psychiatry, Hospital Universitari Vall d'Hebron, Barcelona, Spain.; Biomedical Network Research Centre on Mental Health (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain.; Ridker PM; Divisions of Preventive and Cardiovascular Medicine, Brigham and Women's Hospital & Harvard Medical School, Boston, MA, USA.; Rienstra M; Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.; Risch L; University Institute of Clinical Chemistry, University of Bern, Bern, Switzerland.; Labormedizinisches Zentrum Dr. Risch, Schaan, Liechtenstein.; Roden DM; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; Rosand J; Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Rosenberg MA; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; University of Colorado School of Medicine, Aurora, CO, USA.; Rost N; Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.; J. Philip Kistler Stroke Research Center, Massachusetts General Hospital, Boston, MA, USA.; Rotter JI; Institute for Translational Genomics and Population Sciences, Departments of Pediatrics and Medicine, LABioMed at Harbor-UCLA Medical Center, Torrance, CA, USA.; Saba S; Division of Cardiology, University of Pittsburgh, Pittsburgh, PA, USA.; Sandhu RK; Division of Cardiology, University of Alberta, Edmonton, Alberta, Canada.; Schnabel RB; Department of General and Interventional Cardiology, University Heart Centre Hamburg, Hamburg, Germany.; DZHK (German Centre for Cardiovascular Research), partner site: Hamburg/Kiel/Lübeck, Hamburg, Germany.; Schramm K; Department of Medicine I, University Hospital Munich, Ludwig-Maximilians-University, Munich, Germany.; Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.; Schunkert H; DZHK (German Centre for Cardiovascular Research), partner site: Munich Heart Alliance, Munich, Germany.; Deutsches Herzzentrum München, Klinik für Herz- und Kreislauferkrankungen, Technische Universität München, Munich, Germany.; Schurman C; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Genetics of Obesity and Related Metabolic Traits Program, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Scott SA; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Seppälä I; Department of Clinical Chemistry, Fimlab Laboratories and Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland.; Shaffer C; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; Shah S; Division of Cardiology, Department of Medicine, Duke University School of Medicine, Durham, North Carolina, USA.; Shalaby AA; Division of Cardiology, University of Pittsburgh, Pittsburgh, PA, USA.; Cardiology Division, Pittsburgh VA Healthcare System, Pittsburgh, Pennsylvania, USA.; Shim J; Korea University Anam Hospital, Seoul, Korea.; Shoemaker MB; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; Siland JE; Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.; Sinisalo J; Heart and Lung Center HUS, Helsinki University Central Hospital, Helsinki, Finland.; Sinner MF; Department of Medicine I, University Hospital Munich, Ludwig-Maximilians-University, Munich, Germany.; DZHK (German Centre for Cardiovascular Research), partner site: Munich Heart Alliance, Munich, Germany.; Slowik A; Department of Neurology, Faculty of Medicine, Jagiellonian University Medical College, Krakow, Poland.; Smith AV; Icelandic Heart Association, Kopavogur, Iceland.; Faculty of Medicine, University of Iceland, Reykavik, Iceland.; Smith BH; Division of Population Health Sciences, University of Dundee, Dundee, UK.; Smith JG; Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Cardiology, Clinical Sciences, Lund University and Skåne University Hospital, Lund, Sweden.; Smith JD; Departments of Cardiovascular Medicine, Cellular and Molecular Medicine, Molecular Cardiology, and Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH, USA.; Smith NL; Cardiovascular Health Research Unit and Department of Epidemiology, University of Washington, Seattle, WA, USA.; Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA.; Soliman EZ; Epidemiological Cardiology Research Center (EPICARE), Wake Forest School of Medicine, Winston Salem, NC, USA.; Sotoodehnia N; Cardiovascular Health Research Unit, Departments of Medicine and Epidemiology, University of Washington, Seattle, WA, USA.; Stricker BH; Department of Epidemiology and Internal Medicine, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands.; Inspectorate of Health Care, Utrecht, The Netherlands.; Sun A; Division of Cardiology, Department of Medicine, Duke University School of Medicine, Durham, North Carolina, USA.; Sun H; Departments of Cardiovascular Medicine, Cellular and Molecular Medicine, Molecular Cardiology, and Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH, USA.; Svendsen JH; Laboratory for Molecular Cardiology, The Heart Centre, Department of Cardiology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Tanaka T; Department of Human Genetics and Disease Diversity, Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences, Tokyo, Japan.; Tanriverdi K; University of Massachusetts Medical School Worcester, Worcester, MA, USA.; Taylor KD; Institute for Translational Genomics and Population Sciences, Department of Pediatrics, LABioMed at Harbor-UCLA Medical Center, Torrance, CA, USA.; Teder-Laving M; Estonian Genome Center, University of Tartu, Tartu, Estonia.; Teumer A; DZHK (German Centre for Cardiovascular Research), partner site: Greifswald, Greifswald, Germany.; Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.; Thériault S; Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada.; Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.; Trompet S; Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.; Section of Gerontology and Geriatrics, Department of Internal Medicine, Leiden University Medical Center, Leiden, The Netherlands.; Tucker NR; Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.; Tveit A; Department of Medical Research, Bærum Hospital, Vestre Viken Hospital Trust, Drammen, Norway.; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Uitterlinden AG; Department of Epidemiology and Internal Medicine, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands.; Van Der Harst P; Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.; Van Gelder IC; Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.; Van Wagoner DR; Departments of Cardiovascular Medicine, Cellular and Molecular Medicine, Molecular Cardiology, and Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH, USA.; Verweij N; Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.; Vlachopoulou E; Transplantation Laboratory, Medicum, University of Helsinki, Helsinki, Finland.; Völker U; DZHK (German Centre for Cardiovascular Research), partner site: Greifswald, Greifswald, Germany.; Interfaculty Institute for Genetics and Functional Genomics, University Medicine and Ernst-Moritz-Arndt-University Greifswald, Greifswald, Germany.; Wang B; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.; Weeke PE; Laboratory for Molecular Cardiology, The Heart Centre, Department of Cardiology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; Weijs B; Maastricht University Medical Center+ and Cardiovascular Research Institute Maastricht, Department of Cardiology, Maastricht, The Netherlands.; Weiss R; Division of Cardiovascular Medicine, The Ohio State University, Columbus, OH, USA.; Weiss S; DZHK (German Centre for Cardiovascular Research), partner site: Greifswald, Greifswald, Germany.; Interfaculty Institute for Genetics and Functional Genomics, University Medicine and Ernst-Moritz-Arndt-University Greifswald, Greifswald, Germany.; Wells QS; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; Wiggins KL; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.; Wong JA; Division of Cardiology, Hamilton Health Sciences, McMaster University, Hamilton, Ontario, Canada.; Woo D; University of Cincinnati College of Medicine, Cincinnati, OH, USA.; Worrall BB; Departments of Neurology and Public Health Science, University of Virginia Health System, Charlottesville, VA, USA.; Yang PS; Yonsei University Health System, Seoul, Korea.; Yao J; Institute for Translational Genomics and Population Sciences, Department of Pediatrics, LABioMed at Harbor-UCLA Medical Center, Torrance, CA, USA.; Yoneda ZT; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; Zeller T; Department of General and Interventional Cardiology, University Heart Centre Hamburg, Hamburg, Germany.; DZHK (German Centre for Cardiovascular Research), partner site: Hamburg/Kiel/Lübeck, Hamburg, Germany.; Zeng L; Deutsches Herzzentrum München, Klinik für Herz- und Kreislauferkrankungen, Technische Universität München, Munich, Germany.; Lubitz SA; Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.; Cardiac Arrhythmia Service, Massachusetts General Hospital, Boston, MA, USA.; Lunetta KL; NHLBI and Boston University's Framingham Heart Study, Framingham, MA, USA.; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.; Ellinor PT; Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA. ellinor@mgh.harvard.edu.; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA. ellinor@mgh.harvard.edu.; Cardiac Arrhythmia Service, Massachusetts General Hospital, Boston, MA, USA. ellinor@mgh.harvard.edu. |
| Source: | Nature genetics [Nat Genet] 2018 Jun 11; Vol. 50 (9), pp. 1225-1233. Date of Electronic Publication: 2018 Jun 11. |
| Publication Type: | Journal Article; Meta-Analysis |
| Language: | English |
| Journal Info: | Publisher: Nature Pub. Co Country of Publication: United States NLM ID: 9216904 Publication Model: Electronic Cited Medium: Internet ISSN: 1546-1718 (Electronic) Linking ISSN: 10614036 NLM ISO Abbreviation: Nat Genet Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: New York, NY : Nature Pub. Co., c1992- |
| MeSH Terms: | Atrial Fibrillation/*genetics ; Ethnicity/*genetics; Atrial Fibrillation/ethnology ; Genome-Wide Association Study/methods ; Case-Control Studies ; Genetic Predisposition to Disease ; Humans ; Quantitative Trait Loci ; Transcriptome |
| Abstract: | Atrial fibrillation (AF) affects more than 33 million individuals worldwide1 and has a complex heritability2. We conducted the largest meta-analysis of genome-wide association studies (GWAS) for AF to date, consisting of more than half a million individuals, including 65,446 with AF. In total, we identified 97 loci significantly associated with AF, including 67 that were novel in a combined-ancestry analysis, and 3 that were novel in a European-specific analysis. We sought to identify AF-associated genes at the GWAS loci by performing RNA-sequencing and expression quantitative trait locus analyses in 101 left atrial samples, the most relevant tissue for AF. We also performed transcriptome-wide analyses that identified 57 AF-associated genes, 42 of which overlap with GWAS loci. The identified loci implicate genes enriched within cardiac developmental, electrophysiological, contractile and structural pathways. These results extend our understanding of the biological pathways underlying AF and may facilitate the development of therapeutics for AF. |
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| Grant Information: | U01 HG007417 United States HG NHGRI NIH HHS; R01 HL139731 United States HL NHLBI NIH HHS; R01 HL120393 United States HL NHLBI NIH HHS; R01 HL138737 United States HL NHLBI NIH HHS; R01 HL128914 United States HL NHLBI NIH HHS; R01 HL111314 United States HL NHLBI NIH HHS; K23 HL127296 United States HL NHLBI NIH HHS; MC_PC_17228 United Kingdom MRC_ Medical Research Council; 2014105 United States DDCF Doris Duke Charitable Foundation; R01 HL116747 United States HL NHLBI NIH HHS; K24 HL105780 United States HL NHLBI NIH HHS; R01 HL092217 United States HL NHLBI NIH HHS; L30 HL123413 United States HL NHLBI NIH HHS; R01 HL092577 United States HL NHLBI NIH HHS; T32 GM007569 United States GM NIGMS NIH HHS; MC_QA137853 United Kingdom MRC_ Medical Research Council; U01 HL130114 United States HL NHLBI NIH HHS; U01 HL120393 United States HL NHLBI NIH HHS; 16EIA26410001 United States AHA American Heart Association-American Stroke Association; R01 HL090620 United States HL NHLBI NIH HHS; R01 HL105756 United States HL NHLBI NIH HHS |
| Entry Date(s): | Date Created: 20180613 Date Completed: 20190424 Latest Revision: 20250530 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC6136836 |
| DOI: | 10.1038/s41588-018-0133-9 |
| PMID: | 29892015 |
| Database: | MEDLINE |
Journal Article; Meta-Analysis