Cortical Brain Abnormalities in 4474 Individuals With Schizophrenia and 5098 Control Subjects via the Enhancing Neuro Imaging Genetics Through Meta Analysis (ENIGMA) Consortium.
| Title: | Cortical Brain Abnormalities in 4474 Individuals With Schizophrenia and 5098 Control Subjects via the Enhancing Neuro Imaging Genetics Through Meta Analysis (ENIGMA) Consortium. |
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| Authors: | van Erp TGM; Department of Psychiatry and Human Behavior, University of California, Irvine, Irvine, California. Electronic address: tvanerp@uci.edu.; Walton E; Imaging Genetics and Neuroinformatics Lab, Georgia State University, Atlanta, Georgia.; Hibar DP; Imaging Genetics Center, Mark and Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of the University of Southern California, Marina del Rey, California; Janssen Research & Development, San Diego, California.; Schmaal L; Orygen, The National Centre of Excellence in Youth Mental Health, Melbourne, Victoria, Australia; Centre for Youth Mental Health, University of Melbourne, Melbourne, Victoria, Australia; Department of Psychiatry and Neuroscience, VU University Medical Center, Amsterdam, The Netherlands.; Jiang W; Department of Psychology, Georgia State University, Atlanta, Georgia.; Glahn DC; Department of Psychiatry, Yale University, New Haven, Connecticut; Olin Neuropsychiatric Research Center, Institute of Living, Hartford Hospital, Hartford, Connecticut.; Pearlson GD; Department of Psychiatry, Yale University, New Haven, Connecticut; Olin Neuropsychiatric Research Center, Institute of Living, Hartford Hospital, Hartford, Connecticut.; Yao N; Department of Psychiatry, Yale University, New Haven, Connecticut; Olin Neuropsychiatric Research Center, Institute of Living, Hartford Hospital, Hartford, Connecticut.; Fukunaga M; Division of Cerebral Integration, National Institute for Physiological Sciences, Okazaki, Aichi, Japan.; Hashimoto R; Molecular Research Center for Children's Mental Development, United Graduate School of Child Development, Osaka University, Suita, Osaka, Japan; Department of Psychiatry, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.; Okada N; Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, Bunkyo-ku, Tokyo, Japan.; Yamamori H; Department of Psychiatry, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.; Bustillo JR; Department of Psychiatry, University of New Mexico, Albuquerque, New Mexico.; Clark VP; Department of Psychiatry, University of New Mexico, Albuquerque, New Mexico; Mind Research Network, Albuquerque, New Mexico.; Agartz I; Institute of Clinical Medicine, Norwegian Centre for Mental Disorders Research (NORMENT), K.G. Jebsen Centre for Psychosis Research, University of Oslo, Oslo, Norway; Department of Psychiatric Research, Diakonhjemmet Hospital, Oslo, Norway; Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.; Mueller BA; Department of Psychiatry, University of Minnesota, Minneapolis, Minnesota.; Cahn W; Department of Psychiatry and Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands.; de Zwarte SMC; Department of Psychiatry and Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands.; Hulshoff Pol HE; Department of Psychiatry and Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands.; Kahn RS; Department of Psychiatry and Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands.; Ophoff RA; Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, California; Department of Psychiatry and Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands.; van Haren NEM; Department of Child and Adolescent Psychiatry/Psychology, Erasmus Medical Centre, Rotterdam, The Netherlands; Department of Psychiatry and Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands.; Andreassen OA; Institute of Clinical Medicine, Norwegian Centre for Mental Disorders Research (NORMENT), K.G. Jebsen Centre for Psychosis Research, University of Oslo, Oslo, Norway; Division of Mental Health and Addiction, NORMENT, K.G. Jebsen Centre for Psychosis Research, Oslo University Hospital, Oslo, Norway.; Dale AM; Center for Translational Imaging and Precision Medicine, San Diego, California; Department of Neurosciences, University of California, San Diego, La Jolla, California; Department of Radiology, University of California, San Diego, La Jolla, California; Department of Psychiatry, University of California, San Diego, La Jolla, California; Department of Cognitive Science, University of California, San Diego, La Jolla, California.; Doan NT; Institute of Clinical Medicine, Norwegian Centre for Mental Disorders Research (NORMENT), K.G. Jebsen Centre for Psychosis Research, University of Oslo, Oslo, Norway.; Gurholt TP; Institute of Clinical Medicine, Norwegian Centre for Mental Disorders Research (NORMENT), K.G. Jebsen Centre for Psychosis Research, University of Oslo, Oslo, Norway; Department of Psychiatric Research, Diakonhjemmet Hospital, Oslo, Norway.; Hartberg CB; Institute of Clinical Medicine, Norwegian Centre for Mental Disorders Research (NORMENT), K.G. Jebsen Centre for Psychosis Research, University of Oslo, Oslo, Norway.; Haukvik UK; Institute of Clinical Medicine, Norwegian Centre for Mental Disorders Research (NORMENT), K.G. Jebsen Centre for Psychosis Research, University of Oslo, Oslo, Norway; Division of Mental Health and Addiction, NORMENT, K.G. Jebsen Centre for Psychosis Research, Oslo University Hospital, Oslo, Norway.; Jørgensen KN; Institute of Clinical Medicine, Norwegian Centre for Mental Disorders Research (NORMENT), K.G. Jebsen Centre for Psychosis Research, University of Oslo, Oslo, Norway; Department of Psychiatric Research, Diakonhjemmet Hospital, Oslo, Norway.; Lagerberg TV; Division of Mental Health and Addiction, NORMENT, K.G. Jebsen Centre for Psychosis Research, Oslo University Hospital, Oslo, Norway.; Melle I; Institute of Clinical Medicine, Norwegian Centre for Mental Disorders Research (NORMENT), K.G. Jebsen Centre for Psychosis Research, University of Oslo, Oslo, Norway; Division of Mental Health and Addiction, NORMENT, K.G. Jebsen Centre for Psychosis Research, Oslo University Hospital, Oslo, Norway.; Westlye LT; Department of Psychology, University of Oslo, Oslo, Norway; Division of Mental Health and Addiction, NORMENT, K.G. Jebsen Centre for Psychosis Research, Oslo University Hospital, Oslo, Norway.; Gruber O; Section for Experimental Psychopathology and Neuroimaging, Department of General Psychiatry, Heidelberg University Hospital, Heidelberg, Germany; Center for Translational Research in Systems Neuroscience and Psychiatry, Department of Psychiatry, Georg August University, Göttingen, Germany.; Kraemer B; Section for Experimental Psychopathology and Neuroimaging, Department of General Psychiatry, Heidelberg University Hospital, Heidelberg, Germany; Center for Translational Research in Systems Neuroscience and Psychiatry, Department of Psychiatry, Georg August University, Göttingen, Germany.; Richter A; Section for Experimental Psychopathology and Neuroimaging, Department of General Psychiatry, Heidelberg University Hospital, Heidelberg, Germany; Center for Translational Research in Systems Neuroscience and Psychiatry, Department of Psychiatry, Georg August University, Göttingen, Germany.; Zilles D; Center for Translational Research in Systems Neuroscience and Psychiatry, Department of Psychiatry, Georg August University, Göttingen, Germany; Department of Psychiatry, University Medical Center Göttingen, Göttingen, Germany.; Calhoun VD; Department of Psychiatry, University of New Mexico, Albuquerque, New Mexico; Mind Research Network, Albuquerque, New Mexico.; Crespo-Facorro B; Department of Psychiatry, University Hospital Marqués de Valdecilla, School of Medicine, Marqués de Valdecilla Research Institute (IDIVAL), University of Cantabria, Santander, Spain; Centro Investigación Biomédica en Red de Salud Mental, Santander, Spain.; Roiz-Santiañez R; Department of Psychiatry, University Hospital Marqués de Valdecilla, School of Medicine, Marqués de Valdecilla Research Institute (IDIVAL), University of Cantabria, Santander, Spain; Centro Investigación Biomédica en Red de Salud Mental, Santander, Spain.; Tordesillas-Gutiérrez D; Department of Psychiatry, University Hospital Marqués de Valdecilla, School of Medicine, Marqués de Valdecilla Research Institute (IDIVAL), University of Cantabria, Santander, Spain; Neuroimaging Unit, Technological Facilities, Valdecilla Biomedical Research Institute, Marqués de Valdecilla Research Institute (IDIVAL), University of Cantabria, Santander, Spain; Centro Investigación Biomédica en Red de Salud Mental, Santander, Spain.; Loughland C; Priority Research Centre for Brain & Mental Health, University of Newcastle, Newcastle, New South Wales, Australia; Hunter Medical Research Institute, Newcastle, New South Wales, Australia; Hunter New England Local Health District, Newcastle, New South Wales, Australia.; Carr VJ; Department of Psychiatry, Monash University, Melbourne, Victoria, Australia; School of Psychiatry, University of New South Wales, New South Wales, Australia.; Catts S; Discipline of Psychiatry, School of Medicine, University of Queensland, Brisbane, Queensland, Australia.; Cropley VL; Neuropsychiatry Centre, University of Melbourne, Melbourne, Victoria, Australia.; Fullerton JM; School of Medical Sciences, University of New South Wales, New South Wales, Australia; Neuroscience Research Australia, Sydney, New South Wales, Australia.; Green MJ; School of Psychiatry, University of New South Wales, New South Wales, Australia; Neuroscience Research Australia, Sydney, New South Wales, Australia.; Henskens FA; Priority Research Centre for Health Behaviour, University of Newcastle, Newcastle, New South Wales, Australia; School of Medicine and Public Health, University of Newcastle, Newcastle, New South Wales, Australia; Hunter Medical Research Institute, Newcastle, New South Wales, Australia.; Jablensky A; School of Psychiatry and Clinical Neurosciences, University of Western Australia, Perth, Western Australia, Australia.; Lenroot RK; School of Psychiatry, University of New South Wales, New South Wales, Australia; Neuroscience Research Australia, Sydney, New South Wales, Australia.; Mowry BJ; Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia; Queensland Centre for Mental Health Research, University of Queensland, Brisbane, Queensland, Australia.; Michie PT; School of Psychology, University of Newcastle, Newcastle, New South Wales, Australia.; Pantelis C; Neuropsychiatry Centre, University of Melbourne, Melbourne, Victoria, Australia; Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, Victoria, Australia.; Quidé Y; School of Psychiatry, University of New South Wales, New South Wales, Australia; Neuroscience Research Australia, Sydney, New South Wales, Australia.; Schall U; Priority Research Centre for Brain & Mental Health, University of Newcastle, Newcastle, New South Wales, Australia; Grow Up Well, University of Newcastle, Newcastle, New South Wales, Australia; Hunter Medical Research Institute, Newcastle, New South Wales, Australia.; Scott RJ; School of Biomedical Sciences and Pharmacy, University of Newcastle, Newcastle, New South Wales, Australia; Hunter Medical Research Institute, Newcastle, New South Wales, Australia.; Cairns MJ; School of Biomedical Sciences and Pharmacy, University of Newcastle, Newcastle, New South Wales, Australia; Hunter Medical Research Institute, Newcastle, New South Wales, Australia.; Seal M; Murdoch Children's Research Institute, Melbourne, Victoria, Australia.; Tooney PA; School of Biomedical Sciences and Pharmacy, University of Newcastle, Newcastle, New South Wales, Australia; Priority Research Centre for Brain & Mental Health, University of Newcastle, Newcastle, New South Wales, Australia; Hunter Medical Research Institute, Newcastle, New South Wales, Australia.; Rasser PE; Priority Research Centre for Brain & Mental Health, University of Newcastle, Newcastle, New South Wales, Australia.; Cooper G; Priority Research Centre for Brain & Mental Health, University of Newcastle, Newcastle, New South Wales, Australia.; Shannon Weickert C; School of Psychiatry, University of New South Wales, New South Wales, Australia; Neuroscience Research Australia, Sydney, New South Wales, Australia.; Weickert TW; School of Psychiatry, University of New South Wales, New South Wales, Australia; Neuroscience Research Australia, Sydney, New South Wales, Australia.; Morris DW; Centre for Neuroimaging & Cognitive Genomics, Clinical Neuroimaging Laboratory, National Centre for Biomedical Engineering (NCBES) Galway Neuroscience Centre, College of Medicine Nursing and Health Sciences, National University of Ireland Galway, Galway, Ireland; School of Psychology, and Department of Biochemistry, National University of Ireland Galway, Galway, Ireland; Neuropsychiatric Genetics Research Group, Department of Psychiatry and Trinity College Institute of Neuroscience, Trinity College, Dublin, Ireland.; Hong E; Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, Maryland.; Kochunov P; Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, Maryland.; Beard LM; Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania.; Gur RE; Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania.; Gur RC; Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania.; Satterthwaite TD; Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania.; Wolf DH; Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania.; Belger A; Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; Brain Imaging and Analysis Center, Duke University Medical Center, Durham, North Carolina.; Brown GG; Department of Psychiatry, University of California, San Diego, La Jolla, California.; Ford JM; Department of Psychiatry, Weill Institute for Neurosciences, University of California, San Francisco, California; San Francisco Veterans Affairs Medical Center, San Francisco, California.; Macciardi F; Department of Psychiatry and Human Behavior, University of California, Irvine, Irvine, California.; Mathalon DH; Department of Psychiatry, Weill Institute for Neurosciences, University of California, San Francisco, California; San Francisco Veterans Affairs Medical Center, San Francisco, California.; O'Leary DS; Department of Psychiatry, University of Iowa, Iowa City, Iowa.; Potkin SG; Department of Psychiatry and Human Behavior, University of California, Irvine, Irvine, California.; Preda A; Department of Psychiatry and Human Behavior, University of California, Irvine, Irvine, California.; Voyvodic J; Brain Imaging and Analysis Center, Duke University Medical Center, Durham, North Carolina.; Lim KO; Department of Psychiatry, University of Minnesota, Minneapolis, Minnesota.; McEwen S; Department of Psychiatry & Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, California.; Yang F; Psychiatry Research Center, Beijing Huilongguan Hospital, Beijing, China.; Tan Y; Psychiatry Research Center, Beijing Huilongguan Hospital, Beijing, China.; Tan S; Psychiatry Research Center, Beijing Huilongguan Hospital, Beijing, China.; Wang Z; Psychiatry Research Center, Beijing Huilongguan Hospital, Beijing, China.; Fan F; Psychiatry Research Center, Beijing Huilongguan Hospital, Beijing, China.; Chen J; Psychiatry Research Center, Beijing Huilongguan Hospital, Beijing, China.; Xiang H; Chongqing Three Gorges Central Hospital, Chongqing, China.; Tang S; Chongqing Three Gorges Central Hospital, Chongqing, China.; Guo H; Zhumadian Psychiatry Hospital, Henan Province, Zhumadian, China.; Wan P; Zhumadian Psychiatry Hospital, Henan Province, Zhumadian, China.; Wei D; Luoyang Fifth People's Hospital, Henan Province, Luoyang, China.; Bockholt HJ; Mind Research Network, Albuquerque, New Mexico; Department of Psychiatry, University of Iowa, Iowa City, Iowa; Advanced Biomedical Informatics Group, LLC, Iowa City, Iowa.; Ehrlich S; Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, Massachusetts; Division of Psychological and Social Medicine and Developmental Neurosciences, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany.; Wolthusen RPF; Social Neuroscience Laboratory, Charlestown, Massachusetts; Psychiatric Neuroimaging Research Program, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts; Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts; Division of Psychological and Social Medicine and Developmental Neurosciences, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany.; King MD; Mind Research Network, Albuquerque, New Mexico.; Shoemaker JM; Mind Research Network, Albuquerque, New Mexico.; Sponheim SR; Department of Psychiatry, University of Minnesota, Minneapolis, Minnesota; Minneapolis VA Health Care System, Minneapolis, Minnesota.; De Haan L; Department of Psychiatry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.; Koenders L; Department of Psychiatry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.; Machielsen MW; Department of Psychiatry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.; van Amelsvoort T; Department of Psychiatry & Psychology, Maastricht University, Maastricht, The Netherlands.; Veltman DJ; Department of Psychiatry, Vrije Universiteit Medical Center, Amsterdam, The Netherlands.; Assogna F; Laboratory of Neuropsychiatry, Department of Clinical and Behavioral Neurology, IRCCS Santa Lucia Foundation, Rome, Italy; Centro Fermi, Museo Storico della Fisica e Centro Studi e Ricerche 'Enrico Fermi', Rome, Italy.; Banaj N; Laboratory of Neuropsychiatry, Department of Clinical and Behavioral Neurology, IRCCS Santa Lucia Foundation, Rome, Italy.; de Rossi P; Laboratory of Neuropsychiatry, Department of Clinical and Behavioral Neurology, IRCCS Santa Lucia Foundation, Rome, Italy; Dipartimento di Neuroscienze, Salute Mentale e Organi di Senso (NESMOS), Faculty of Medicine and Psychology, and Department of Neurology and Psychiatry, Sapienza University of Rome, Rome, Italy.; Iorio M; Laboratory of Neuropsychiatry, Department of Clinical and Behavioral Neurology, IRCCS Santa Lucia Foundation, Rome, Italy.; Piras F; Laboratory of Neuropsychiatry, Department of Clinical and Behavioral Neurology, IRCCS Santa Lucia Foundation, Rome, Italy; Centro Fermi, Museo Storico della Fisica e Centro Studi e Ricerche 'Enrico Fermi', Rome, Italy.; Spalletta G; Beth K. and Stuart C. Yudofsky Division of Neuropsychiatry, Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, Texas; Laboratory of Neuropsychiatry, Department of Clinical and Behavioral Neurology, IRCCS Santa Lucia Foundation, Rome, Italy.; McKenna PJ; Fundación para la Investigación y Docencia Maria Angustias Giménez (FIDMAG) Germanes Hospitalaries Research Foundation, Barcelona, Spain; Centro Investigación Biomédica en Red de Salud Mental, Barcelona, Spain.; Pomarol-Clotet E; Fundación para la Investigación y Docencia Maria Angustias Giménez (FIDMAG) Germanes Hospitalaries Research Foundation, Barcelona, Spain; Centro Investigación Biomédica en Red de Salud Mental, Barcelona, Spain.; Salvador R; Fundación para la Investigación y Docencia Maria Angustias Giménez (FIDMAG) Germanes Hospitalaries Research Foundation, Barcelona, Spain; Centro Investigación Biomédica en Red de Salud Mental, Barcelona, Spain.; Corvin A; Neuropsychiatric Genetics Research Group, Department of Psychiatry and Trinity College Institute of Neuroscience, Trinity College, Dublin, Ireland.; Donohoe G; Centre for Neuroimaging & Cognitive Genomics, Clinical Neuroimaging Laboratory, National Centre for Biomedical Engineering (NCBES) Galway Neuroscience Centre, College of Medicine Nursing and Health Sciences, National University of Ireland Galway, Galway, Ireland; School of Psychology, and Department of Biochemistry, National University of Ireland Galway, Galway, Ireland; Neuropsychiatric Genetics Research Group, Department of Psychiatry and Trinity College Institute of Neuroscience, Trinity College, Dublin, Ireland.; Kelly S; Department of Psychiatry, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts; Psychiatry Neuroimaging Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.; Whelan CD; Imaging Genetics Center, Mark and Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of the University of Southern California, Marina del Rey, California.; Dickie EW; Centre for Addiction and Mental Health, Toronto, Canada.; Rotenberg D; Centre for Addiction and Mental Health, Toronto, Canada.; Voineskos AN; Centre for Addiction and Mental Health, Toronto, Canada.; Ciufolini S; Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.; Radua J; Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden; Fundación para la Investigación y Docencia Maria Angustias Giménez (FIDMAG) Germanes Hospitalaries Research Foundation, Barcelona, Spain; Centro Investigación Biomédica en Red de Salud Mental, Barcelona, Spain; Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.; Dazzan P; Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom; National Institute for Health Research Mental Health Biomedical Research Centre at South London and Maudsley NHS Foundation Trust, London, United Kingdom.; Murray R; Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.; Reis Marques T; Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.; Simmons A; Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.; Borgwardt S; University of Basel Psychiatric Hospital, Basel, Switzerland.; Egloff L; University of Basel Psychiatric Hospital, Basel, Switzerland.; Harrisberger F; University of Basel Psychiatric Hospital, Basel, Switzerland.; Riecher-Rössler A; University of Basel Psychiatric Hospital, Basel, Switzerland.; Smieskova R; University of Basel Psychiatric Hospital, Basel, Switzerland.; Alpert KI; Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, Illinois.; Wang L; Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, Illinois; Department of Radiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois.; Jönsson EG; Institute of Clinical Medicine, Norwegian Centre for Mental Disorders Research (NORMENT), K.G. Jebsen Centre for Psychosis Research, University of Oslo, Oslo, Norway; Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.; Koops S; Department of Psychiatry and Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands.; Sommer IEC; Department of Neuroscience, University Medical Center Groningen, Rijks Universiteit Groningen, Groningen, The Netherlands; Department of Psychiatry, University Medical Center Groningen, Rijks Universiteit Groningen, Groningen, The Netherlands.; Bertolino A; Department of Basic Medical Science, Neuroscience and Sense Organs, University of Bari 'Aldo Moro,' Bari, Italy.; Bonvino A; Istituto Di Ricovero e Cura a Carattere Scientifico Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy.; Di Giorgio A; Istituto Di Ricovero e Cura a Carattere Scientifico Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy.; Neilson E; Division of Psychiatry, University of Edinburgh, Edinburgh, United Kingdom.; Mayer AR; Mind Research Network, Albuquerque, New Mexico.; Stephen JM; Mind Research Network, Albuquerque, New Mexico.; Kwon JS; Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea; Department of Brain & Cognitive Sciences, College of Natural Sciences, Seoul National University, Seoul, Republic of Korea.; Yun JY; Yeongeon Student Support Center, Seoul National University College of Medicine, Seoul, Republic of Korea; Seoul National University Hospital, Seoul, Republic of Korea.; Cannon DM; Centre for Neuroimaging & Cognitive Genomics, Clinical Neuroimaging Laboratory, National Centre for Biomedical Engineering (NCBES) Galway Neuroscience Centre, College of Medicine Nursing and Health Sciences, National University of Ireland Galway, Galway, Ireland.; McDonald C; Centre for Neuroimaging & Cognitive Genomics, Clinical Neuroimaging Laboratory, National Centre for Biomedical Engineering (NCBES) Galway Neuroscience Centre, College of Medicine Nursing and Health Sciences, National University of Ireland Galway, Galway, Ireland.; Lebedeva I; Mental Health Research Center, Moscow, Russia.; Tomyshev AS; Mental Health Research Center, Moscow, Russia.; Akhadov T; Children's Clinical and Research Institute of Emergency Surgery and Trauma, Moscow, Russia.; Kaleda V; Mental Health Research Center, Moscow, Russia.; Fatouros-Bergman H; Centre for Psychiatry Research, Karolinska Institutet, Stockholm, Sweden; Stockholm Health Services, Stockholm County Council, Stockholm, Sweden.; Flyckt L; Centre for Psychiatry Research, Karolinska Institutet, Stockholm, Sweden; Stockholm Health Services, Stockholm County Council, Stockholm, Sweden.; Busatto GF; Laboratory of Psychiatric Neuroimaging, Laboratórios de Investigação Médica 21, Department of Psychiatry, Faculty of Medicine, and Center for Interdisciplinary Research on Applied Neurosciences, University of São Paulo, São Paulo, Brazil.; Rosa PGP; Laboratory of Psychiatric Neuroimaging, Laboratórios de Investigação Médica 21, Department of Psychiatry, Faculty of Medicine, and Center for Interdisciplinary Research on Applied Neurosciences, University of São Paulo, São Paulo, Brazil.; Serpa MH; Laboratory of Psychiatric Neuroimaging, Laboratórios de Investigação Médica 21, Department of Psychiatry, Faculty of Medicine, and Center for Interdisciplinary Research on Applied Neurosciences, University of São Paulo, São Paulo, Brazil.; Zanetti MV; Laboratory of Psychiatric Neuroimaging, Laboratórios de Investigação Médica 21, Department of Psychiatry, Faculty of Medicine, and Center for Interdisciplinary Research on Applied Neurosciences, University of São Paulo, São Paulo, Brazil.; Hoschl C; National Institute of Mental Health, Klecany, Czech Republic.; Skoch A; National Institute of Mental Health, Klecany, Czech Republic; MR Unit, Department of Diagnostic and Interventional Radiology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic.; Spaniel F; National Institute of Mental Health, Klecany, Czech Republic.; Tomecek D; National Institute of Mental Health, Klecany, Czech Republic; Institute of Computer Science, Czech Academy of Sciences, Czech Technical University in Prague, Prague, Czech Republic; Faculty of Electrical Engineering, Czech Technical University in Prague, Prague, Czech Republic.; Hagenaars SP; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, United Kingdom; Department of Psychology, University of Edinburgh, Edinburgh, United Kingdom.; McIntosh AM; Division of Psychiatry, University of Edinburgh, Edinburgh, United Kingdom; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, United Kingdom.; Whalley HC; Division of Psychiatry, University of Edinburgh, Edinburgh, United Kingdom.; Lawrie SM; Division of Psychiatry, University of Edinburgh, Edinburgh, United Kingdom.; Knöchel C; Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Goethe University Frankfurt, Frankfurt, Germany.; Oertel-Knöchel V; Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Goethe University Frankfurt, Frankfurt, Germany.; Stäblein M; Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Goethe University Frankfurt, Frankfurt, Germany.; Howells FM; Department of Psychiatry, Groote Schuur Hospital, University of Cape Town, Cape Town, South Africa.; Stein DJ; Department of Psychiatry, Groote Schuur Hospital, University of Cape Town, Cape Town, South Africa; Medical Research Council Unit on Risk & Resilience in Mental Disorders, Department of Psychiatry, University of Cape Town, Cape Town, South Africa.; Temmingh HS; Department of Psychiatry, Groote Schuur Hospital, University of Cape Town, Cape Town, South Africa.; Uhlmann A; Department of Psychiatry, Groote Schuur Hospital, University of Cape Town, Cape Town, South Africa; Medical Research Council Unit on Risk & Resilience in Mental Disorders, Department of Psychiatry, Stellenbosch University, Cape Town, South Africa.; Lopez-Jaramillo C; Research Group in Psychiatry, Department of Psychiatry, Faculty of Medicine, Universidad de Antioquia, Medellin, Colombia.; Dima D; Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom; Department of Psychology, City, University of London, London, United Kingdom.; McMahon A; Imaging Genetics Center, Mark and Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of the University of Southern California, Marina del Rey, California.; Faskowitz JI; Imaging Genetics Center, Mark and Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of the University of Southern California, Marina del Rey, California.; Gutman BA; Department of Biomedical Engineering, Illinois Institute of Technology, Chicago, Illinois.; Jahanshad N; Imaging Genetics Center, Mark and Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of the University of Southern California, Marina del Rey, California.; Thompson PM; Imaging Genetics Center, Mark and Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of the University of Southern California, Marina del Rey, California.; Turner JA; Imaging Genetics and Neuroinformatics Lab, Georgia State University, Atlanta, Georgia; Mind Research Network, Albuquerque, New Mexico. |
| Corporate Authors: | Karolinska Schizophrenia Project |
| Source: | Biological psychiatry [Biol Psychiatry] 2018 Nov 01; Vol. 84 (9), pp. 644-654. Date of Electronic Publication: 2018 May 14. |
| Publication Type: | Journal Article; Meta-Analysis; Research Support, N.I.H., Extramural |
| Language: | English |
| Journal Info: | Publisher: Elsevier Country of Publication: United States NLM ID: 0213264 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2402 (Electronic) Linking ISSN: 00063223 NLM ISO Abbreviation: Biol Psychiatry Subsets: MEDLINE |
| Imprint Name(s): | Publication: New York, NY : Elsevier; Original Publication: New York, Plenum Pub. Corp. |
| MeSH Terms: | Brain/*pathology ; Schizophrenia/*diagnostic imaging ; Schizophrenia/*pathology; Brain/diagnostic imaging ; Frontal Lobe/diagnostic imaging ; Frontal Lobe/pathology ; Prefrontal Cortex/diagnostic imaging ; Prefrontal Cortex/pathology ; Temporal Lobe/diagnostic imaging ; Temporal Lobe/pathology ; Adolescent ; Adult ; Age of Onset ; Aged ; Case-Control Studies ; Child ; Female ; Humans ; Linear Models ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Neuroimaging ; Severity of Illness Index ; Young Adult |
| Abstract: | Background: The profile of cortical neuroanatomical abnormalities in schizophrenia is not fully understood, despite hundreds of published structural brain imaging studies. This study presents the first meta-analysis of cortical thickness and surface area abnormalities in schizophrenia conducted by the ENIGMA (Enhancing Neuro Imaging Genetics through Meta Analysis) Schizophrenia Working Group.; Methods: The study included data from 4474 individuals with schizophrenia (mean age, 32.3 years; range, 11-78 years; 66% male) and 5098 healthy volunteers (mean age, 32.8 years; range, 10-87 years; 53% male) assessed with standardized methods at 39 centers worldwide.; Results: Compared with healthy volunteers, individuals with schizophrenia have widespread thinner cortex (left/right hemisphere: Cohen's d = -0.530/-0.516) and smaller surface area (left/right hemisphere: Cohen's d = -0.251/-0.254), with the largest effect sizes for both in frontal and temporal lobe regions. Regional group differences in cortical thickness remained significant when statistically controlling for global cortical thickness, suggesting regional specificity. In contrast, effects for cortical surface area appear global. Case-control, negative, cortical thickness effect sizes were two to three times larger in individuals receiving antipsychotic medication relative to unmedicated individuals. Negative correlations between age and bilateral temporal pole thickness were stronger in individuals with schizophrenia than in healthy volunteers. Regional cortical thickness showed significant negative correlations with normalized medication dose, symptom severity, and duration of illness and positive correlations with age at onset.; Conclusions: The findings indicate that the ENIGMA meta-analysis approach can achieve robust findings in clinical neuroscience studies; also, medication effects should be taken into account in future genetic association studies of cortical thickness in schizophrenia.; (Copyright © 2018 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.) |
| Comments: | Comment in: Biol Psychiatry. 2018 Nov 1;84(9):626-628. doi: 10.1016/j.biopsych.2018.06.005.. (PMID: 30297020); Comment in: Biol Psychiatry. 2019 Apr 1;85(7):e33. doi: 10.1016/j.biopsych.2018.07.029.. (PMID: 30470560); Comment in: Biol Psychiatry. 2019 Apr 1;85(7):e35-e39. doi: 10.1016/j.biopsych.2018.10.003.. (PMID: 30470561) |
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| Grant Information: | R01 MH116948 United States MH NIMH NIH HHS; P50 MH064045 United States MH NIMH NIH HHS; R01 EB015611 United States EB NIBIB NIH HHS; C0439 United Kingdom MRF_ MRF_; R01 EB006841 United States EB NIBIB NIH HHS; R01 MH060722 United States MH NIMH NIH HHS; MR/K026992/1 United Kingdom MRC_ Medical Research Council; R01 DA027680 United States DA NIDA NIH HHS; T32 MH067533 United States MH NIMH NIH HHS; U54 HD079124 United States HD NICHD NIH HHS; UL1 TR000153 United States TR NCATS NIH HHS; K01 MH099431 United States MH NIMH NIH HHS; R01 MH084803 United States MH NIMH NIH HHS; UL1 RR025758 United States RR NCRR NIH HHS; R01 MH107703 United States MH NIMH NIH HHS; RC1 MH089257 United States MH NIMH NIH HHS; P20 GM103472 United States GM NIGMS NIH HHS; T32 MH019112 United States MH NIMH NIH HHS; R01 MH056584 United States MH NIMH NIH HHS; R37 MH043775 United States MH NIMH NIH HHS; R01 EB005846 United States EB NIBIB NIH HHS; R01 MH094524 United States MH NIMH NIH HHS; R01 MH101111 United States MH NIMH NIH HHS; P41 RR014075 United States RR NCRR NIH HHS; MR/S015132/1 United Kingdom MRC_ Medical Research Council; U01 MH108148 United States MH NIMH NIH HHS; U54 EB020403 United States EB NIBIB NIH HHS; P50 AA022534 United States AA NIAAA NIH HHS; UL1 TR001414 United States TR NCATS NIH HHS; U24 RR021992 United States RR NCRR NIH HHS; K23 MH085096 United States MH NIMH NIH HHS; P50 MH103222 United States MH NIMH NIH HHS; R01 MH112180 United States MH NIMH NIH HHS; R01 GM061603 United States GM NIGMS NIH HHS; S10 OD023696 United States OD NIH HHS; R01 MH058251 United States MH NIMH NIH HHS; MC_UU_00011/5 United Kingdom MRC_ Medical Research Council; U24 RR025736 United States RR NCRR NIH HHS; P50 MH071616 United States MH NIMH NIH HHS; R01 MH074797 United States MH NIMH NIH HHS; R01 MH085646 United States MH NIMH NIH HHS; R01 EB020407 United States EB NIBIB NIH HHS; R01 AA021771 United States AA NIAAA NIH HHS |
| Contributed Indexing: | Investigator: L Farde; L Flyckt; G Engberg; S Erhardt; H Fatouros-Bergman; S Cervenka; L Schwieler; F Piehl; I Agartz; K Collste; P Victorsson; A Malmqvist; M Hedberg; F Orhan; Keywords: Cortical; Imaging; Meta-analysis; Schizophrenia; Surface area; Thickness |
| Entry Date(s): | Date Created: 20180702 Date Completed: 20191015 Latest Revision: 20250530 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC6177304 |
| DOI: | 10.1016/j.biopsych.2018.04.023 |
| PMID: | 29960671 |
| Database: | MEDLINE |
Journal Article; Meta-Analysis; Research Support, N.I.H., Extramural