Skin Nerve Phosphorylated α-Synuclein Deposits in Parkinson Disease With Orthostatic Hypotension.
| Title: | Skin Nerve Phosphorylated α-Synuclein Deposits in Parkinson Disease With Orthostatic Hypotension. |
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| Authors: | Donadio V; IRCCS Istituto delle Scienze Neurologiche di Bologna, Italy.; Incensi A; IRCCS Istituto delle Scienze Neurologiche di Bologna, Italy.; Del Sorbo F; Fondazione IRCCS Istituto Neurologico Carlo Besta, Milano, Italy.; Rizzo G; IRCCS Istituto delle Scienze Neurologiche di Bologna, Italy.; Fondazione IRCCS Istituto Neurologico Carlo Besta, Milano, Italy.; Dipartimento di Scienze Biomediche e Neuromotorie, Università di Bologna, Bologna, Italy.; Infante R; IRCCS Istituto delle Scienze Neurologiche di Bologna, Italy.; Dipartimento di Scienze Biomediche e Neuromotorie, Università di Bologna, Bologna, Italy.; Scaglione C; IRCCS Istituto delle Scienze Neurologiche di Bologna, Italy.; Modugno N; IRCCS Neuromed Pozzilli, Isernia, Italy.; Fileccia E; IRCCS Istituto delle Scienze Neurologiche di Bologna, Italy.; Dipartimento di Scienze Biomediche e Neuromotorie, Università di Bologna, Bologna, Italy.; Elia AE; Fondazione IRCCS Istituto Neurologico Carlo Besta, Milano, Italy.; Cencini F; IRCCS Istituto delle Scienze Neurologiche di Bologna, Italy.; Dipartimento di Scienze Biomediche e Neuromotorie, Università di Bologna, Bologna, Italy.; Liguori R; IRCCS Istituto delle Scienze Neurologiche di Bologna, Italy.; Dipartimento di Scienze Biomediche e Neuromotorie, Università di Bologna, Bologna, Italy. |
| Source: | Journal of neuropathology and experimental neurology [J Neuropathol Exp Neurol] 2018 Oct 01; Vol. 77 (10), pp. 942-949. |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: Oxford University Press Country of Publication: England NLM ID: 2985192R Publication Model: Print Cited Medium: Internet ISSN: 1554-6578 (Electronic) Linking ISSN: 00223069 NLM ISO Abbreviation: J Neuropathol Exp Neurol Subsets: MEDLINE |
| Imprint Name(s): | Publication: 2016- : Oxford, England : Oxford University Press; Original Publication: Lawrence, Ks : Association of the journal of neuropathology and experimental neurology |
| MeSH Terms: | Hypotension, Orthostatic/*metabolism ; Parkinson Disease/*metabolism ; Skin/*innervation ; Skin/*metabolism ; alpha-Synuclein/*metabolism; Biomarkers/metabolism ; Hypotension, Orthostatic/diagnosis ; Hypotension, Orthostatic/epidemiology ; Nerve Fibers/metabolism ; Parkinson Disease/diagnosis ; Parkinson Disease/epidemiology ; Phosphorylation/physiology ; Aged ; Aged, 80 and over ; Female ; Follow-Up Studies ; Humans ; Male ; Middle Aged |
| Abstract: | This study aimed to investigate phosphorylated α-synuclein (p-syn) in autonomic skin nerves of Parkinson disease (PD) patients with and without orthostatic hypotension (OH). We studied 28 PD patients with normal corrected Mini-Mental State Examination including 14 patients with neurogenic OH (PD + OH) and 14 matched patients did not complain of OH (PD - OH); 7 of whom were re-evaluated over a follow-up period (4 ± 2 years). Skin biopsy was performed in proximal and distal sites. PD + OH patients showed a higher p-syn deposition than PD - OH, with widespread autonomic cholinergic and adrenergic skin nerve involvement. Over the follow-up period, PD - OH patients showed an increase in motor dysfunction scores without autonomic symptoms and a slight increase of skin p-syn deposition but still lower than PD + OH, mainly restricted to adrenergic fibers of skin vessels (SV). In summary, PD + OH patients showed a wide involvement of p-syn deposits in autonomic cholinergic and adrenergic skin nerves compared with PD - OH, and PD - OH patients showed a lower load of skin p-syn restricted to adrenergic fibers of SV still persisting over the follow-up period. The data supported a different pathogenesis between PD + OH and PD - OH and may help to identify a specific diagnostic trait for PD + OH. |
| Substance Nomenclature: | 0 (Biomarkers); 0 (alpha-Synuclein) |
| Entry Date(s): | Date Created: 20180824 Date Completed: 20191003 Latest Revision: 20191007 |
| Update Code: | 20260130 |
| DOI: | 10.1093/jnen/nly074 |
| PMID: | 30137426 |
| Database: | MEDLINE |
Journal Article