Secretory carcinoma: the eastern Canadian experience and literature review.
| Title: | Secretory carcinoma: the eastern Canadian experience and literature review. |
|---|---|
| Authors: | Forner D; Division of Otolaryngology - Head & Neck Surgery, Department of Surgery, Dalhousie University, 5820 University Ave. 3rd Floor Dickson Bldg, Halifax, NS, B3H 2Y9, Canada. david.forner@dal.ca.; Bullock M; Department of Pathology, Dalhousie University, Halifax, NS, Canada.; Manders D; Department of Pathology, Dalhousie University, Halifax, NS, Canada.; Wallace T; Division of Otolaryngology - Head & Neck Surgery, Department of Surgery, Dalhousie University, 5820 University Ave. 3rd Floor Dickson Bldg, Halifax, NS, B3H 2Y9, Canada.; Division of Otolaryngology - Head & Neck Surgery, Department of Surgery, Cumberland Regional Health Care Center, Amherst, NS, Canada.; Chin CJ; Division of Otolaryngology - Head & Neck Surgery, Department of Surgery, Dalhousie University, 5820 University Ave. 3rd Floor Dickson Bldg, Halifax, NS, B3H 2Y9, Canada.; Division of Otolaryngology - Head & Neck Surgery, Department of Surgery, Saint John Regional Hospital, Saint John, NB, Canada.; Johnson LB; Division of Otolaryngology - Head & Neck Surgery, Department of Surgery, Dalhousie University, 5820 University Ave. 3rd Floor Dickson Bldg, Halifax, NS, B3H 2Y9, Canada.; Rigby MH; Division of Otolaryngology - Head & Neck Surgery, Department of Surgery, Dalhousie University, 5820 University Ave. 3rd Floor Dickson Bldg, Halifax, NS, B3H 2Y9, Canada.; Trites JR; Division of Otolaryngology - Head & Neck Surgery, Department of Surgery, Dalhousie University, 5820 University Ave. 3rd Floor Dickson Bldg, Halifax, NS, B3H 2Y9, Canada.; Taylor MS; Division of Otolaryngology - Head & Neck Surgery, Department of Surgery, Dalhousie University, 5820 University Ave. 3rd Floor Dickson Bldg, Halifax, NS, B3H 2Y9, Canada.; Hart RD; Division of Otolaryngology - Head & Neck Surgery, Department of Surgery, Dalhousie University, 5820 University Ave. 3rd Floor Dickson Bldg, Halifax, NS, B3H 2Y9, Canada. |
| Source: | Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale [J Otolaryngol Head Neck Surg] 2018 Nov 16; Vol. 47 (1), pp. 69. Date of Electronic Publication: 2018 Nov 16. |
| Publication Type: | Journal Article; Multicenter Study; Review |
| Language: | English |
| Journal Info: | Publisher: SAGE Publications Country of Publication: United States NLM ID: 101479544 Publication Model: Electronic Cited Medium: Internet ISSN: 1916-0216 (Electronic) Linking ISSN: 19160208 NLM ISO Abbreviation: J Otolaryngol Head Neck Surg Subsets: MEDLINE |
| Imprint Name(s): | Publication: 2024- : [Thousand Oaks] : SAGE Publications; Original Publication: Hamilton, Ont. : Decker |
| MeSH Terms: | Breast Neoplasms/*epidemiology ; Carcinoma/*epidemiology ; Parotid Neoplasms/*surgery ; Salivary Gland Neoplasms/*epidemiology ; Salivary Gland Neoplasms/*pathology; Breast Neoplasms/pathology ; Breast Neoplasms/therapy ; Carcinoma/pathology ; Carcinoma/therapy ; Neoplasm Invasiveness/pathology ; Parotid Neoplasms/epidemiology ; Parotid Neoplasms/pathology ; Salivary Gland Neoplasms/therapy ; Adult ; Aged ; Biopsy, Fine-Needle ; Cohort Studies ; Combined Modality Therapy ; Female ; Humans ; Immunohistochemistry ; Kaplan-Meier Estimate ; Male ; Middle Aged ; Neoplasm Staging ; Nova Scotia ; Retrospective Studies ; Survival Analysis |
| Abstract: | Background: Secretory Carcinoma (SC) is a recently described malignancy affecting salivary glands of the head and neck, with a paucity of evidence regarding the natural history, morbidity, and mortality. This study aimed to investigate the current treatment options utilized for SC, as well as its presentation and outcomes.; Methods: This study is a retrospective case series and includes patients diagnosed with SC at four Maritime Canadian institutions. Literature review of patient outcomes following treatment of SC is also included.; Results: Thirteen patients were identified. Parotid was the most common subsite (69%), followed by minor salivary gland (23%) and submandibular gland (8%). All patients were S100 positive and had at least one additional positive confirmatory stain, including mammaglobin, CK7, or vimentin. Two patients had N2b disease. All patients were treated with primary surgery, and four were offered adjuvant radiotherapy. There was one instance of locoregional recurrence, and one of metastasis. Three patients displayed perineural invasion on pathology, and one patient displayed lymphovascular invasion.; Conclusion: Secretory Carcinoma remains understudied regarding its natural history, presentation, and treatment options. This study is the largest single case series in Canada, and highlights the young age and possible aggressiveness of SC. As well, we provide the most comprehensive literature review to date, with a focus on treatment and outcomes for this disease entity. |
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| Contributed Indexing: | Keywords: Canada; Diagnostics; ETV6-NTRK3 mutation; Salivary gland; Secretory carcinoma |
| SCR Disease Name: | Secretory breast carcinoma |
| Entry Date(s): | Date Created: 20181118 Date Completed: 20190313 Latest Revision: 20190313 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC6240209 |
| DOI: | 10.1186/s40463-018-0315-6 |
| PMID: | 30446016 |
| Database: | MEDLINE |
Journal Article; Multicenter Study; Review