Diagnostic and prognostic significance of cardiovascular magnetic resonance native myocardial T1 mapping in patients with pulmonary hypertension.
| Title: | Diagnostic and prognostic significance of cardiovascular magnetic resonance native myocardial T1 mapping in patients with pulmonary hypertension. |
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| Authors: | Saunders LC; POLARIS, Academic Radiology, Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, UK.; Johns CS; POLARIS, Academic Radiology, Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, UK.; Stewart NJ; POLARIS, Academic Radiology, Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, UK.; Division of Bioengineering and Bioinformatics, Graduate School of Information Science and Technology, Hokkaido University, Hokudai, Japan.; Oram CJE; POLARIS, Academic Radiology, Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, UK.; Capener DA; POLARIS, Academic Radiology, Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, UK.; Puntmann VO; Institute for Experimental and Translational Cardio Vascular Imaging, University Hospital Frankfurt, Frankfurt, Germany.; Elliot CA; Pulmonary Vascular Disease Unit, Sheffield Teaching Hospitals NHS Trust, Sheffield, UK.; Condliffe RC; Pulmonary Vascular Disease Unit, Sheffield Teaching Hospitals NHS Trust, Sheffield, UK.; Kiely DG; Pulmonary Vascular Disease Unit, Sheffield Teaching Hospitals NHS Trust, Sheffield, UK.; INSIGNEO, Institute for in-silico medicine, Sheffield, UK.; Graves MJ; University of Cambridge School of Clinical Medicine, Cambridge University, Cambridge, UK.; Wild JM; POLARIS, Academic Radiology, Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, UK. j.m.wild@sheffield.ac.uk.; INSIGNEO, Institute for in-silico medicine, Sheffield, UK. j.m.wild@sheffield.ac.uk.; Swift AJ; POLARIS, Academic Radiology, Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, UK.; INSIGNEO, Institute for in-silico medicine, Sheffield, UK. |
| Source: | Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance [J Cardiovasc Magn Reson] 2018 Dec 03; Vol. 20 (1), pp. 78. Date of Electronic Publication: 2018 Dec 03. |
| Publication Type: | Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
| Language: | English |
| Journal Info: | Publisher: Elsevier Country of Publication: England NLM ID: 9815616 Publication Model: Electronic Cited Medium: Internet ISSN: 1532-429X (Electronic) Linking ISSN: 10976647 NLM ISO Abbreviation: J Cardiovasc Magn Reson Subsets: MEDLINE |
| Imprint Name(s): | Publication: 2024- : London : Elsevier; Original Publication: New York : M. Dekker, Inc., c1998- |
| MeSH Terms: | Hypertension, Pulmonary/*diagnostic imaging ; Image Interpretation, Computer-Assisted/*methods ; Magnetic Resonance Imaging, Cine/*methods; Hypertension, Pulmonary/mortality ; Hypertension, Pulmonary/physiopathology ; Adult ; Aged ; Aged, 80 and over ; Disease Progression ; Female ; Hemodynamics ; Humans ; Male ; Middle Aged ; Predictive Value of Tests ; Prognosis ; Retrospective Studies ; Ventricular Function, Left ; Ventricular Function, Right ; Ventricular Remodeling |
| Abstract: | Background: Native T1 may be a sensitive, contrast-free, non-invasive cardiovascular magnetic resonance (CMR) marker of myocardial tissue changes in patients with pulmonary artery hypertension. However, the diagnostic and prognostic value of native T1 mapping in this patient group has not been fully explored. The aim of this work was to determine whether elevation of native T1 in myocardial tissue in pulmonary hypertension: (a) varies according to pulmonary hypertension subtype; (b) has prognostic value and (c) is associated with ventricular function and interaction.; Methods: Data were retrospectively collected from a total of 490 consecutive patients during their clinical 1.5 T CMR assessment at a pulmonary hypertension referral centre in 2015. Three hundred sixty-nine patients had pulmonary hypertension [58 ± 15 years; 66% female], an additional 39 had pulmonary hypertension due to left heart disease [68 ± 13 years; 60% female], 82 patients did not have pulmonary hypertension [55 ± 18; 68% female]. Twenty five healthy subjects were also recruited [58 ±4 years); 51% female]. T1 mapping was performed with a MOdified Look-Locker Inversion Recovery (MOLLI) sequence. T1 prognostic value in patients with pulmonary arterial hypertension was assessed using multivariate Cox proportional hazards regression analysis.; Results: Patients with pulmonary artery hypertension had elevated T1 in the right ventricular (RV) insertion point (pulmonary hypertension patients: T1 = 1060 ± 90 ms; No pulmonary hypertension patients: T1 = 1020 ± 80 ms p |
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| Grant Information: | 205188/Z/16/Z United Kingdom WT_ Wellcome Trust; MR/M008894/1 United Kingdom MRC_ Medical Research Council; NIHR-RP-R3-12-027 United Kingdom DH_ Department of Health; SP/14/6/31350 United Kingdom BHF_ British Heart Foundation |
| Contributed Indexing: | Keywords: Cardiovascular magnetic resonance; MOLLI; Pulmonary hypertension; T1 mapping |
| Entry Date(s): | Date Created: 20181204 Date Completed: 20190314 Latest Revision: 20250530 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC6276188 |
| DOI: | 10.1186/s12968-018-0501-8 |
| PMID: | 30501639 |
| Database: | MEDLINE |
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't