Blood-Brain Delivery Methods Using Nanotechnology.
| Title: | Blood-Brain Delivery Methods Using Nanotechnology. |
|---|---|
| Authors: | Teleanu DM; Emergency University Hospital, Bucharest, Romania, 'Carol Davila' University of Medicine and Pharmacy, 050474 Bucharest, Romania. telepapa@hotmail.com.; Chircov C; Faculty of Engineering in Foreign Languages, Politehnica University of Bucharest, 060042 București, Romania. cristina.chircov@yahoo.com.; Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, Politehnica University of Bucharest, 060042 București, Romania. cristina.chircov@yahoo.com.; Grumezescu AM; Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, Politehnica University of Bucharest, 060042 București, Romania. grumezescu@yahoo.com.; ICUB-Research Institute of University of Bucharest, University of Bucharest, 36-46 M. Kogalniceanu Blvd., 050107 Bucharest, Romania. grumezescu@yahoo.com.; Volceanov A; Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, Politehnica University of Bucharest, 060042 București, Romania. avolceanov@yahoo.co.uk.; Teleanu RI; Emergency University Hospital, Bucharest, Romania, 'Carol Davila' University of Medicine and Pharmacy, 050474 Bucharest, Romania. raluca.teleanu@umfcd.ro. |
| Source: | Pharmaceutics [Pharmaceutics] 2018 Dec 11; Vol. 10 (4). Date of Electronic Publication: 2018 Dec 11. |
| Publication Type: | Journal Article; Review |
| Language: | English |
| Journal Info: | Publisher: MDPI Country of Publication: Switzerland NLM ID: 101534003 Publication Model: Electronic Cited Medium: Print ISSN: 1999-4923 (Print) Linking ISSN: 19994923 NLM ISO Abbreviation: Pharmaceutics Subsets: PubMed not MEDLINE |
| Imprint Name(s): | Original Publication: Basel, Switzerland : MDPI |
| Abstract: | Pathologies of the brain, of which brain cancer, Alzheimer's disease, Parkinson's disease, stroke, and multiple sclerosis, are some of the most prevalent, and that presently are poorly treated due to the difficulties associated with drug development, administration, and targeting to the brain. The existence of the blood-brain barrier, a selective permeability system which acts as a local gateway against circulating foreign substances, represents the key challenge for the delivery of therapeutic agents to the brain. However, the development of nanotechnology-based approaches for brain delivery, such as nanoparticles, liposomes, dendrimers, micelles, and carbon nanotubes, might be the solution for improved brain therapies. |
| References: | Cells. 2018 Mar 23;7(4):. (PMID: 29570659); Colloids Surf B Biointerfaces. 2016 Nov 1;147:242-249. (PMID: 27518456); J Pharm Sci. 2017 Sep;106(9):2606-2613. (PMID: 28322936); Int J Pharm. 2018 Jun 10;544(1):191-202. (PMID: 29678547); Eur J Pharm Biopharm. 2017 Oct;119:253-263. (PMID: 28652141); J Control Release. 2018 Sep 10;285:212-229. (PMID: 30009891); J Pharm Sci. 2018 Nov;107(11):2902-2913. (PMID: 30055226); Eur J Pharm Sci. 2016 Apr 30;86:67-74. (PMID: 26924227); J Colloid Interface Sci. 2016 Nov 15;482:142-150. (PMID: 27501037); J Control Release. 2018 Dec 10;291:65-79. (PMID: 30308255); Int J Pharm. 2017 Jun 30;526(1-2):413-424. (PMID: 28495580); Drug Discov Today Technol. 2016 Jun;20:35-39. (PMID: 27986221); J Control Release. 2016 Nov 10;241:1-14. (PMID: 27586188); Mol Ther. 2018 Nov 7;26(11):2580-2591. (PMID: 30143435); J Control Release. 2017 Jan 28;246:98-109. (PMID: 28017889); Int J Biol Macromol. 2018 Dec;120(Pt B):2579-2588. (PMID: 30195608); Mol Immunol. 2018 Oct;102:26-31. (PMID: 30007547); Nanomedicine (Lond). 2017 Jul;12(13):1533-1546. (PMID: 28621578); Biomaterials. 2015;53:437-52. (PMID: 25890741); J Control Release. 2017 Mar 10;249:173-182. (PMID: 28137632); ACS Nano. 2015 Oct 27;9(10):9470-4. (PMID: 26406936); Biomater Sci. 2016 Feb;4(2):219-29. (PMID: 26646694); Nanoscale. 2014 Feb 21;6(4):2146-52. (PMID: 24362586); Theranostics. 2018 Feb 5;8(6):1481-1493. (PMID: 29556336); Int J Pharm. 2018 Aug 25;547(1-2):563-571. (PMID: 29906562); Int J Pharm. 2017 May 30;524(1-2):77-90. (PMID: 28359811); Nanomedicine. 2018 Oct;14(7):2341-2350. (PMID: 29079529); CNS Drugs. 2017 Feb;31(2):109-133. (PMID: 28101766); Bioorg Med Chem. 2018 Sep 1;26(16):4677-4686. (PMID: 30098913); Pharmacol Rev. 2018 Apr;70(2):278-314. (PMID: 29496890); Tissue Barriers. 2016 Jan 08;4(1):e1138017. (PMID: 27141420); J Cereb Blood Flow Metab. 2016 Feb;36(2):451-5. (PMID: 26661200); Curr Pharm Des. 2016;22(9):1177-1193. (PMID: 26685681); Mol Membr Biol. 2014 Aug;31(5):152-67. (PMID: 25046533); J Pharm Sci. 2018 Apr;107(4):1143-1156. (PMID: 29183742); ACS Appl Mater Interfaces. 2017 Jun 21;9(24):20410-20416. (PMID: 28541655); J Ayurveda Integr Med. 2020 Jan - Mar;11(1):24-36. (PMID: 30115410); J Control Release. 2017 May 10;253:165-171. (PMID: 28322975); Colloids Surf B Biointerfaces. 2019 Jan 1;173:27-35. (PMID: 30261346); J Neurosci Methods. 2019 Jan 1;311:133-146. (PMID: 30336221); Int J Pharm. 2018 Jul 10;545(1-2):113-116. (PMID: 29680280); Eur J Pharm Biopharm. 2016 Dec;109:130-139. (PMID: 27702684); Int J Nanomedicine. 2015 Aug 04;10:4981-5003. (PMID: 26345528); J Control Release. 2018 Sep 28;286:264-278. (PMID: 30071253); J Control Release. 2016 Dec 10;243:357-369. (PMID: 27794494); J Neuroimmune Pharmacol. 2006 Sep;1(3):223-36. (PMID: 18040800); Bull World Health Organ. 2018 May 1;96(5):298-298A. (PMID: 29875510); Biomed Res Int. 2015;2015:812673. (PMID: 26075264); Int J Pharm. 2017 Sep 15;530(1-2):263-278. (PMID: 28774853); Nanomedicine. 2017 Jul;13(5):1645-1652. (PMID: 28285163); Bioimpacts. 2016;6(4):225-248. (PMID: 28265539); Biomaterials. 2017 Oct;141:29-39. (PMID: 28666100); PLoS One. 2016 Aug 22;11(8):e0160705. (PMID: 27547955); J Control Release. 2016 Mar 10;225:217-29. (PMID: 26809004); J Mater Chem B. 2015 Apr 21;3(15):2935-2938. (PMID: 32262492); Biomaterials. 2016 Sep;101:96-107. (PMID: 27267631); J Nanobiotechnology. 2018 Feb 13;16(1):13. (PMID: 29433522); Small. 2014 Dec 29;10(24):5137-50. (PMID: 25104165); Nanomedicine. 2019 Jan;15(1):1-11. (PMID: 30189294); Nanomedicine. 2016 Feb;12(2):421-30. (PMID: 26711963); J Clin Invest. 2017 Aug 1;127(8):2897-2899. (PMID: 28737511); J Control Release. 2018 Jul 10;281:139-177. (PMID: 29772289); Handb Clin Neurol. 2016;133:39-59. (PMID: 27112670) |
| Contributed Indexing: | Keywords: Alzheimer’s disease; Parkinson’s disease; brain; brain cancer; brain delivery; carbon nanotubes; dendrimers; liposomes; micelles; nanoparticles |
| Entry Date(s): | Date Created: 20181215 Latest Revision: 20231005 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC6321434 |
| DOI: | 10.3390/pharmaceutics10040269 |
| PMID: | 30544966 |
| Database: | MEDLINE |
Journal Article; Review