Impact of polymorphism of selected genes on the diagnosis of type 2 diabetes in patients with obstructive sleep apnea.
| Title: | Impact of polymorphism of selected genes on the diagnosis of type 2 diabetes in patients with obstructive sleep apnea. |
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| Authors: | Bielicki P; Department of Internal Medicine, Pulmonary Diseases and Allergy, Medical University of Warsaw, Warsaw, Poland; Pływaczewski R; 2nd Department of Respiratory Medicine, Institute for Tuberculosis and Lung Diseases, Warsaw, Warsaw, Poland; Brzóska K; Centre for Radiobiology and Biological Dosimetry, Institute of Nuclear Chemistry and Technology, Warsaw, Poland; Kumor M; Department of Internal Medicine, Pulmonary Diseases and Allergy, Medical University of Warsaw, Warsaw, Poland; Barnaś M; Department of Internal Medicine, Pulmonary Diseases and Allergy, Medical University of Warsaw, Warsaw, Poland; Jonczak L; 2nd Department of Respiratory Medicine, Institute for Tuberculosis and Lung Diseases, Warsaw, Warsaw, Poland; Stępkowski TM; Centre for Radiobiology and Biological Dosimetry, Institute of Nuclear Chemistry and Technology, Warsaw, Poland; Piechuta A; Department of Internal Medicine, Pulmonary Diseases and Allergy, Medical University of Warsaw, Warsaw, Poland; Chazan R; Department of Internal Medicine, Pulmonary Diseases and Allergy, Medical University of Warsaw, Warsaw, Poland; Śliwiński P; 2nd Department of Respiratory Medicine, Institute for Tuberculosis and Lung Diseases, Warsaw, Warsaw, Poland; Kruszewski M; Centre for Radiobiology and Biological Dosimetry, Institute of Nuclear Chemistry and Technology, Warsaw, Poland; Department of Molecular Biology and Translational Research, Institute of Rural Health, Lublin, Poland |
| Source: | Polish archives of internal medicine [Pol Arch Intern Med] 2019 Jan 31; Vol. 129 (1), pp. 6-11. Date of Electronic Publication: 2018 Dec 29. |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: Medycyna Praktyczna Country of Publication: Poland NLM ID: 101700960 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1897-9483 (Electronic) Linking ISSN: 00323772 NLM ISO Abbreviation: Pol Arch Intern Med Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Liszki, Poland : Medycyna Praktyczna, [2017]- |
| MeSH Terms: | Apolipoprotein A-V* ; Genetic Predisposition to Disease* ; Polymorphism, Single Nucleotide*; Diabetes Mellitus, Type 2/*diagnosis ; Sleep Apnea, Obstructive/*complications; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/genetics ; Female ; Humans ; Male ; Middle Aged |
| Abstract: | INTRODUCTION Although the coexistence of type 2 diabetes mellitus (T2DM) and obstructive sleep apnea (OSA) may be attributed to environmental risk factors common for both diseases, a genetic background should also be considered. Data on the role of genetic factors in the development of T2DM in patients with OSA are lacking. OBJECTIVES The study was aimed to evaluate the prevalence of polymorphisms of selected genes that are known to be associated with diabetes or obesity in patients with OSA and concomitant T2DM and to assess these polymorphisms in the context of OSA severity. PATIENTS AND METHODS Consecutive patients with newly diagnosed OSA confirmed by polysomnography underwent genotyping for the following single nucleotide polymorphisms (SNPs): SREBF1 rs11868035, HIF1A rs11549465, APOA5 rs3135506, TCF7L2 rs7903146, and FTO rs16945088. The frequency of genotypes was compared between patients with and without concomitant T2DM and was analyzed with regard to OSA severity. RESULTS A total of 600 patients with newly diagnosed OSA were enrolled to the study. Of these, 121 patients (20.2%) were diagnosed with T2DM (97 men and 24 women; median age, 58 years; range, 52-64 years). The prevalence of T2DM was significantly lower in APOA5 rs3135506 GG homozygotes than in CG heterozygotes (18.8% vs 33.3%, P = 0.02). APOA5 rs3135506 CG heterozygotes were at higher risk for developing T2DM (adjusted odds ratio, 2.64; 95% confidence interval,1.38-5.04; P = 0.003). No significant differences were found for the genotype distribution of the other investigated SNPs. CONCLUSIONS Our study shows a possible link between the polymorphism of the gene encoding APOA5 and T2DM in patients with OSA. |
| Comments: | Comment in: Pol Arch Intern Med. 2019 Jan 31;129(1):4-5. doi: 10.20452/pamw.4431.. (PMID: 30702652) |
| Substance Nomenclature: | 0 (APOA5 protein, human); 0 (Apolipoprotein A-V) |
| Entry Date(s): | Date Created: 20190103 Date Completed: 20200220 Latest Revision: 20200220 |
| Update Code: | 20260130 |
| DOI: | 10.20452/pamw.4406 |
| PMID: | 30600310 |
| Database: | MEDLINE |
Journal Article