Long-term health-related quality of life of critically ill patients with haematological malignancies: a prospective observational multicenter study.
| Title: | Long-term health-related quality of life of critically ill patients with haematological malignancies: a prospective observational multicenter study. |
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| Authors: | Ehooman F; Medical ICU, Saint-Louis Teaching Hospital, 1 Avenue Claude Vellefaux, 75010, Paris, France.; Biard L; Biostatistics Department, Saint-Louis Teaching Hospital, Paris, France.; Lemiale V; Medical ICU, Saint-Louis Teaching Hospital, 1 Avenue Claude Vellefaux, 75010, Paris, France.; Contou D; Medical ICU, Henri Mondor Teaching Hospital, Paris, France.; ICU, Albert Michallon University Hospital, Grenoble, France.; ICU, Saint-Etienne University Hospital, Saint-Etienne, France.; de Prost N; Medical ICU, Henri Mondor Teaching Hospital, Paris, France.; ICU, Albert Michallon University Hospital, Grenoble, France.; ICU, Saint-Etienne University Hospital, Saint-Etienne, France.; Mokart D; Medical ICU, Henri Mondor Teaching Hospital, Paris, France.; Pène F; ICU, Paoli Calmette Institute, Marseille, France.; Kouatchet A; Medical ICU, Cochin Teaching Hospital, Paris, France.; Mayaux J; Medical ICU, Angers Teaching Hospital, Angers, France.; Demoule A; Medical ICU, Angers Teaching Hospital, Angers, France.; Vincent F; Medical ICU, Pitié-Salpétrière Teaching Hospital, Paris, France.; Nyunga M; ICU, Avicenne Teaching Hospital, Bobigny, France.; Bruneel F; ICU, Roubaix Hospital, Roubaix, France.; Rabbat A; ICU, Mignot Hospital, Versailles, France.; Lebert C; Respiratory Unit, Cochin Teaching Hospital, Paris, France.; Perez P; ICU, Vendée hospital, La Roche sur Yon, France.; Meert AP; ICU, Brabois Teaching Hospital, Nancy, France.; Benoit D; Service soins intensifs et urgences oncologiques, Institut Jules Bordet, Brussels, Belgium.; Hamidfar R; ICU, Ghent Teaching Hospital, Ghent, Belgium.; Darmon M; ICU, Albert Michallon University Hospital, Grenoble, France.; Azoulay E; Medical ICU, Saint-Louis Teaching Hospital, 1 Avenue Claude Vellefaux, 75010, Paris, France.; Zafrani L; Medical ICU, Saint-Louis Teaching Hospital, 1 Avenue Claude Vellefaux, 75010, Paris, France. lara.zafrani@aphp.fr. |
| Source: | Annals of intensive care [Ann Intensive Care] 2019 Jan 05; Vol. 9 (1), pp. 2. Date of Electronic Publication: 2019 Jan 05. |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 101562873 Publication Model: Electronic Cited Medium: Print ISSN: 2110-5820 (Print) Linking ISSN: 21105820 NLM ISO Abbreviation: Ann Intensive Care Subsets: PubMed not MEDLINE |
| Imprint Name(s): | Original Publication: Heidelberg : Springer-Verlag, 2011- |
| Abstract: | Background: Although outcomes of critically ill patients with haematological malignancies (HMs) have been fully investigated in terms of organ failure and mortality, data are scarce on health-related quality of life (HRQOL) in this population. We aim to assess post-intensive care unit (ICU) burden and HRQOL of critically ill patients with HMs and to identify risk factors for quality-of-life (QOL) impairment.; Results: In total, 1011 patients with HMs who required ICU admission in 17 ICUs in France and Belgium were included in the study; 278 and 117 patients were evaluated for QOL at 3 months and 1 year, respectively, after ICU discharge. HRQOL was determined by applying the interview form of the Short Form 36 (SF-36) questionnaire. Psychological distress symptoms were evaluated using the Hospital Anxiety Depression Score (HADS) and the Impact of Event Scale (IES). In-hospital mortality rates at 3 months and 1 year were, respectively, 39.1, 50.7 and 57.2%, respectively. At 3 months, median [IQR] physical and mental component summary scores (PCS and MCS) (SF-36) were 37 [28-46] and 51 [45-58], respectively. PCS was lower in ICU patients with HMs when compared to general ICU septic patients (52 [5-13], p = 0.00001). The median combined HAD score was 8 [5-13], and the median IES score was 8 [3-16]. However, recovery during the first year after ICU discharge was not consistent in all dimensions of HRQOL. Three months after ICU discharge, the maximum daily Sequential Organ Failure Assessment score and status of the underlying malignancy at ICU admission were significantly associated with MCS impairment (- 0.54 points [95% CI - 0.99; - 0.1], p = 0.018 and - 4.83 points [95% CI - 8.44; - 1.22], p = 0.009, respectively).; Conclusion: HRQOL is strongly impaired in critically ill patients with HMs at 3 months and 1 year after ICU discharge. Organ failure and disease status are strongly associated with QOL. The kinetic evaluation of QOL at 3 months and 1 year offers the opportunity to focus on QOL aspects that may be improved by therapeutic interventions during the first year after ICU discharge. |
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| Grant Information: | PHRC AOM 08235 French Ministry of Health |
| Contributed Indexing: | Keywords: Anxiety; Depression; Haematological malignancy; Intensive care unit; Long-term health-related quality of life; Post-traumatic syndrome disorder |
| Entry Date(s): | Date Created: 20190107 Latest Revision: 20260329 |
| Update Code: | 20260329 |
| PubMed Central ID: | PMC6320707 |
| DOI: | 10.1186/s13613-018-0478-3 |
| PMID: | 30612249 |
| Database: | MEDLINE |
Journal Article