The Roles of Ubiquitin-Binding Protein Shuttles in the Degradative Fate of Ubiquitinated Proteins in the Ubiquitin-Proteasome System and Autophagy.
| Title: | The Roles of Ubiquitin-Binding Protein Shuttles in the Degradative Fate of Ubiquitinated Proteins in the Ubiquitin-Proteasome System and Autophagy. |
|---|---|
| Authors: | Zientara-Rytter K; Section of Molecular Biology, Division of Biological Sciences, University California, San Diego, CA 92093-0322, USA. kzientararytter@ucsd.edu.; Subramani S; Section of Molecular Biology, Division of Biological Sciences, University California, San Diego, CA 92093-0322, USA. ssubramani@ucsd.edu. |
| Source: | Cells [Cells] 2019 Jan 10; Vol. 8 (1). Date of Electronic Publication: 2019 Jan 10. |
| Publication Type: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
| Language: | English |
| Journal Info: | Publisher: MDPI Country of Publication: Switzerland NLM ID: 101600052 Publication Model: Electronic Cited Medium: Print ISSN: 2073-4409 (Print) Linking ISSN: 20734409 NLM ISO Abbreviation: Cells Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Basel, Switzerland : MDPI |
| MeSH Terms: | Proteasome Endopeptidase Complex/*metabolism ; Ubiquitin/*metabolism ; Ubiquitin-Protein Ligase Complexes/*metabolism ; Ubiquitinated Proteins/*metabolism; Plants/metabolism ; Yeasts/metabolism ; Animals ; Autophagy ; Humans ; Proteolysis ; Ubiquitination |
| Abstract: | The ubiquitin-proteasome system (UPS) and autophagy are the two major intracellular protein quality control (PQC) pathways that are responsible for cellular proteostasis (homeostasis of the proteome) by ensuring the timely degradation of misfolded, damaged, and unwanted proteins. Ubiquitination serves as the degradation signal in both these systems, but substrates are precisely targeted to one or the other pathway. Determining how and when cells target specific proteins to these two alternative PQC pathways and control the crosstalk between them are topics of considerable interest. The ubiquitin (Ub) recognition code based on the type of Ub-linked chains on substrate proteins was believed to play a pivotal role in this process, but an increasing body of evidence indicates that the PQC pathway choice is also made based on other criteria. These include the oligomeric state of the Ub-binding protein shuttles, their conformation, protein modifications, and the presence of motifs that interact with ATG8/LC3/GABARAP (autophagy-related protein 8/microtubule-associated protein 1A/1B-light chain 3/GABA type A receptor-associated protein) protein family members. In this review, we summarize the current knowledge regarding the Ub recognition code that is bound by Ub-binding proteasomal and autophagic receptors. We also discuss how cells can modify substrate fate by modulating the structure, conformation, and physical properties of these receptors to affect their shuttling between both degradation pathways. |
| Competing Interests: | The authors declare no conflict of interest. |
| References: | J Cell Biol. 2005 Apr 25;169(2):285-95. (PMID: 15837803); Sci Rep. 2015 May 11;5:10210. (PMID: 25958982); J Cell Sci. 2013 Aug 1;126(Pt 15):3237-47. (PMID: 23908376); J Biol Chem. 2006 Jul 7;281(27):18793-801. (PMID: 16636050); Autophagy. 2013 Dec;9(12):1955-64. (PMID: 24128730); Mol Cell. 2016 Jul 7;63(1):34-48. (PMID: 27345151); Traffic. 2011 May;12(5):579-90. (PMID: 21291504); Biochem Biophys Res Commun. 2006 Nov 24;350(3):768-73. (PMID: 17027914); Cell Death Differ. 2013 Jan;20(1):12-20. (PMID: 22653340); J Biol Chem. 2000 Aug 18;275(33):25445-50. (PMID: 10856287); J Biol Chem. 2004 Jul 23;279(30):31883-90. (PMID: 15143057); Neurosci Lett. 2011 Oct 10;503(3):234-9. (PMID: 21896309); Front Neurosci. 2017 Apr 06;11:185. (PMID: 28428740); Plant Cell. 2011 Jul;23(7):2754-73. (PMID: 21764993); Mol Cell Biol. 2006 Mar;26(5):1579-88. (PMID: 16478980); Cell Mol Life Sci. 2015 May;72(9):1811-24. (PMID: 25403879); Biochem J. 2011 May 1;435(3):597-608. (PMID: 21294713); Biochim Biophys Acta. 2013 Dec;1833(12):3134-3144. (PMID: 24021263); Biochem Biophys Res Commun. 2005 Oct 21;336(2):530-5. (PMID: 16140271); Mol Cell Biol. 2011 Jan;31(1):105-17. (PMID: 20974803); Mol Cell. 2009 Feb 27;33(4):505-16. (PMID: 19250911); J Biol Chem. 2003 Mar 14;278(11):8951-9. (PMID: 12643283); Mol Cell Biol. 2009 Jun;29(12):3307-18. (PMID: 19364824); J Biol Chem. 2005 Oct 14;280(41):34840-8. (PMID: 16091361); Mol Cell. 2013 Sep 12;51(5):618-31. (PMID: 24011591); Nat Cell Biol. 2002 Sep;4(9):725-30. (PMID: 12198498); Nat Cell Biol. 2012 Oct;14(10):1024-35. (PMID: 23023224); Proc Natl Acad Sci U S A. 1998 Jul 7;95(14):7898-903. (PMID: 9653112); Exp Mol Med. 2015 Mar 13;47:e147. (PMID: 25766616); Angew Chem Int Ed Engl. 2013 Jan 2;52(1):192-8. (PMID: 23124625); PLoS One. 2014 Jul 01;9(7):e101206. (PMID: 24983867); Curr Opin Cell Biol. 2010 Apr;22(2):124-31. (PMID: 20034776); J Biochem. 2017 Feb 1;161(2):113-124. (PMID: 28069863); J Biol Chem. 2011 Sep 9;286(36):31864-74. (PMID: 21715324); Biochim Biophys Acta. 2014 Jan;1843(1):197-204. (PMID: 23523933); Biochim Biophys Acta. 2014 Jan;1843(1):86-96. (PMID: 23872423); Autophagy. 2017 Jan 2;13(1):133-148. (PMID: 27846364); J Cell Sci. 2013 Feb 15;126(Pt 4):939-52. (PMID: 23239026); Nat Cell Biol. 2015 Mar;17(3):262-75. (PMID: 25686248); J Mol Biol. 2017 Nov 10;429(22):3500-3524. (PMID: 28583440); Nat Cell Biol. 2001 Oct;3(10):939-43. (PMID: 11584278); FEBS J. 2015 Dec;282(24):4672-8. (PMID: 26432171); Biochem Biophys Res Commun. 2002 May 10;293(3):986-92. (PMID: 12051757); Soft Matter. 2015 May 21;11(19):3786-93. (PMID: 25846269); Protein Cell. 2016 Feb;7(2):114-29. (PMID: 26746706); Biochemistry. 2003 Nov 25;42(46):13529-35. (PMID: 14621999); Mol Cell. 2011 Oct 21;44(2):279-89. (PMID: 22017874); J Mol Biol. 2014 Dec 12;426(24):4049-4060. (PMID: 25311859); Cell Cycle. 2009 Jul 1;8(13):1986-90. (PMID: 19502794); Autophagy. 2014 Jun;10(6):1036-53. (PMID: 24879152); Cell Rep. 2017 Apr 4;19(1):188-202. (PMID: 28380357); J Mol Biol. 2002 Jun 21;319(5):1243-55. (PMID: 12079361); Acta Crystallogr D Biol Crystallogr. 2006 Feb;62(Pt 2):177-88. (PMID: 16421449); J Biol Chem. 2017 Aug 18;292(33):13795-13808. (PMID: 28655770); Int J Biochem Mol Biol. 2013 Mar 31;4(1):1-26. (PMID: 23638318); J Biol Chem. 2011 Feb 4;286(5):3618-29. (PMID: 21059646); Trends Biochem Sci. 2004 Dec;29(12):637-40. (PMID: 15544949); J Biol Chem. 2014 May 16;289(20):13890-902. (PMID: 24692539); J Biol Chem. 2002 Mar 1;277(9):7059-65. (PMID: 11751856); Mol Cell Biol. 2005 Aug;25(16):7120-36. (PMID: 16055722); Cell. 2007 Dec 14;131(6):1149-63. (PMID: 18083104); Science. 1989 Mar 24;243(4898):1576-83. (PMID: 2538923); Int J Cell Biol. 2012;2012:736905. (PMID: 22518139); Proc Natl Acad Sci U S A. 2017 Mar 7;114(10):E2026-E2035. (PMID: 28223514); Cell Rep. 2017 Aug 22;20(8):1994. (PMID: 28834760); Mol Cell Biol. 2010 Dec;30(24):5672-85. (PMID: 20937771); J Biol Chem. 2010 Feb 19;285(8):5941-53. (PMID: 20018885); Mol Cell. 2012 Feb 24;45(4):553-66. (PMID: 22365832); Annu Rev Biochem. 2012;81:203-29. (PMID: 22524316); Proc Natl Acad Sci U S A. 2002 Jan 22;99(2):745-50. (PMID: 11805328); J Biol Chem. 2003 Sep 5;278(36):34568-81. (PMID: 12813044); Cell Death Differ. 2013 Jan;20(1):21-30. (PMID: 22722335); J Cell Biol. 2011 Jan 10;192(1):17-27. (PMID: 21220506); Autophagy. 2010 Oct;6(7):979-80. (PMID: 20729634); J Mol Biol. 2001 Nov 9;313(5):955-63. (PMID: 11700052); Mol Cell Biol. 2001 Mar;21(6):1997-2007. (PMID: 11238935); Int J Cell Biol. 2012;2012:673290. (PMID: 22536250); J Biol Chem. 2002 Apr 5;277(14):11691-5. (PMID: 11805121); Nat Rev Mol Cell Biol. 2015 May;16(5):322-4. (PMID: 25907614); Mol Cell Biol. 2003 Nov;23(21):7554-65. (PMID: 14560003); J Cell Sci. 2017 Nov 15;130(22):3839-3850. (PMID: 29021346); Autophagy. 2019 Apr;15(4):583-598. (PMID: 30290707); Nature. 2007 Jun 14;447(7146):859-63. (PMID: 17568747); Curr Biol. 2000 Dec 14-28;10(24):1603-6. (PMID: 11137014); J Biol Chem. 2008 Mar 14;283(11):6783-9. (PMID: 18174161); Mol Cell. 2010 Apr 23;38(2):265-79. (PMID: 20417604); Nat Rev Mol Cell Biol. 2005 Aug;6(8):610-21. (PMID: 16064137); Autophagy. 2016 Oct 2;12(10):1945-1953. (PMID: 27484196); Autophagy. 2011 Sep;7(9):993-1010. (PMID: 21606687); Mol Cell. 2000 Aug;6(2):409-19. (PMID: 10983987); Nat Commun. 2016 Jan 12;7:10318. (PMID: 26754771); FEBS Lett. 2006 Jun 12;580(14):3401-8. (PMID: 16712842); Curr Biol. 2007 Aug 21;17(16):1438-43. (PMID: 17702576); Hum Mol Genet. 2010 Aug 15;19(16):3219-32. (PMID: 20529957); J Biol Chem. 1995 Jul 21;270(29):17442-56. (PMID: 7615550); Cell Cycle. 2010 Sep 15;9(18):3685-6. (PMID: 20890104); FEBS Lett. 2014 Mar 3;588(5):822-8. (PMID: 24492006); Mol Cell. 2016 Mar 3;61(5):720-733. (PMID: 26942676); Proc Natl Acad Sci U S A. 2014 Oct 21;111(42):E4439-48. (PMID: 25294927); Biochim Biophys Acta. 2014 Jan;1843(1):163-81. (PMID: 23545414); Semin Cell Dev Biol. 2004 Apr;15(2):247-59. (PMID: 15209385); Autophagy. 2011 Oct;7(10):1145-58. (PMID: 21670587); Cell. 2016 Jun 30;166(1):152-66. (PMID: 27368102); Cell Host Microbe. 2015 Apr 8;17(4):515-25. (PMID: 25771791); Mol Cell. 2012 Oct 26;48(2):242-53. (PMID: 22959274); J Mol Cell Cardiol. 2008 Jul;45(1):11-27. (PMID: 18495153); Immunity. 2012 Aug 24;37(2):223-34. (PMID: 22921120); Mol Cell. 2015 Oct 1;60(1):7-20. (PMID: 26365381); Front Plant Sci. 2014 Jan 31;5:13. (PMID: 24550923); BMC Biol. 2011 May 31;9:33. (PMID: 21627799); FEBS Lett. 2004 Jul 30;571(1-3):171-6. (PMID: 15280037); Biochim Biophys Acta. 2015 Feb;1852(2):188-94. (PMID: 25092168); Science. 2011 Jul 8;333(6039):228-33. (PMID: 21617041); Nat Struct Mol Biol. 2005 Aug;12(8):708-14. (PMID: 16007098); Hum Mol Genet. 2003 Apr 1;12(7):749-57. (PMID: 12651870); PLoS Genet. 2013;9(1):e1003196. (PMID: 23341779); Nat Cell Biol. 2006 Jul;8(7):700-10. (PMID: 16799550); PLoS One. 2010 Feb 11;5(2):e9168. (PMID: 20161783); Mol Biol Cell. 2016 Jul 1;27(13):2025-36. (PMID: 27170182); EMBO J. 2009 Apr 8;28(7):889-901. (PMID: 19229298); Nat Methods. 2011 Jul 10;8(8):691-6. (PMID: 21743460); Trends Immunol. 2016 Sep;37(9):621-633. (PMID: 27480243); Mol Cell. 2011 Oct 21;44(2):325-40. (PMID: 21906983); Cell Res. 2014 Jan;24(1):24-41. (PMID: 24366339); Microbes Infect. 2012 Feb;14(2):140-7. (PMID: 21930231); Proc Natl Acad Sci U S A. 2003 Oct 28;100(22):12694-9. (PMID: 14557549); Biochem J. 2006 Nov 1;399(3):397-404. (PMID: 16813565); Microb Cell. 2016 Apr 16;3(5):224-226. (PMID: 28358147); Nat Cell Biol. 2010 Feb;12(2):119-31. (PMID: 20098416); Nat Biotechnol. 2003 Aug;21(8):921-6. (PMID: 12872131); Genetics. 1999 Sep;153(1):69-79. (PMID: 10471701); J Biol Chem. 2012 Apr 27;287(18):14659-71. (PMID: 22318722); Biochem Biophys Res Commun. 2008 Sep 12;374(1):33-7. (PMID: 18598672); J Cell Sci. 2013 Jan 15;126(Pt 2):580-92. (PMID: 23178947); Proc Natl Acad Sci U S A. 2016 Apr 12;113(15):4039-44. (PMID: 27035970); Nat Cell Biol. 2015 Jul;17(7):917-29. (PMID: 26075355); Mol Cell. 2008 Nov 7;32(3):415-25. (PMID: 18995839); EMBO Rep. 2011 Feb;12(2):149-56. (PMID: 21252941); J Biol Chem. 2008 Feb 29;283(9):5748-59. (PMID: 18079109); J Biol Chem. 2017 Feb 24;292(8):3379-3388. (PMID: 28082672); J Biol Chem. 2007 Jun 15;282(24):17375-86. (PMID: 17426036); Mol Cell Biol. 2005 Jul;25(13):5355-62. (PMID: 15964793); Nat Struct Biol. 2001 May;8(5):417-22. (PMID: 11323716); EMBO Rep. 2013 Apr;14(4):373-81. (PMID: 23459205); Nat Struct Mol Biol. 2008 Jun;15(6):573-80. (PMID: 18511945); Cell Rep. 2016 Nov 22;17(9):2183-2194. (PMID: 27880896); J Mol Biol. 2006 Dec 1;364(3):376-87. (PMID: 17010377); Neuron. 2002 Jan 3;33(1):63-74. (PMID: 11779480); J Biol Chem. 2007 Aug 17;282(33):24131-45. (PMID: 17580304); Cell. 2008 May 16;133(4):653-65. (PMID: 18485873); PLoS Genet. 2015 Feb 27;11(2):e1004987. (PMID: 25723488); J Biol Chem. 2004 Jun 25;279(26):26817-22. (PMID: 15117949); J Cell Biol. 2005 Nov 21;171(4):603-14. (PMID: 16286508); Biochem Biophys Res Commun. 2010 May 7;395(3):426-31. (PMID: 20382112); Mol Cell. 2003 Jul;12(1):39-50. (PMID: 12887891); J Biol Chem. 2000 Feb 18;275(7):4613-7. (PMID: 10671488); Nature. 1995 Jan 5;373(6509):81-3. (PMID: 7800044); Hum Mol Genet. 2002 Oct 15;11(22):2689-700. (PMID: 12374759); Biol Chem. 2012 May;393(6):441-7. (PMID: 22628307); Nature. 2008 May 22;453(7194):481-8. (PMID: 18497817); DNA Repair (Amst). 2009 Apr 5;8(4):449-60. (PMID: 19223247); J Cell Sci. 2017 Oct 1;130(19):3336-3346. (PMID: 28966167); Nature. 2000 Apr 13;404(6779):770-4. (PMID: 10783891); Nat Cell Biol. 2017 Jun;19(6):732-739. (PMID: 28504708); FEBS Lett. 2006 Jan 9;580(1):341-4. (PMID: 16376336); J Biol Chem. 2003 Sep 19;278(38):36621-7. (PMID: 12832454); Hum Mol Genet. 2008 Feb 1;17(3):431-9. (PMID: 17981811); Genes Cells. 2004 Jul;9(7):611-8. (PMID: 15265004); DNA Cell Biol. 2013 May;32(5):220-7. (PMID: 23530606); Prion. 2013 Mar-Apr;7(2):164-9. (PMID: 23360761); J Biol Chem. 2008 Feb 29;283(9):5427-40. (PMID: 18083707); Sci Rep. 2014 Nov 20;4:7138. (PMID: 25409783); EMBO Rep. 2009 Feb;10(2):173-9. (PMID: 19148225); J Cell Biol. 2017 May 1;216(5):1301-1320. (PMID: 28404643); Annu Rev Biochem. 2017 Jun 20;86:193-224. (PMID: 28460188); Autophagy. 2009 Jul;5(5):732-3. (PMID: 19398892); In Vitro Cell Dev Biol Anim. 2015 Mar;51(3):249-63. (PMID: 25385288); J Biol Chem. 2005 Jul 1;280(26):24610-7. (PMID: 15857831); Autophagy. 2014 Jul;10(7):1341-2. (PMID: 24852146); J Biol Chem. 2013 Sep 6;288(36):25780-91. (PMID: 23880770); Structure. 2015 Mar 3;23(3):542-557. (PMID: 25703377); Cell. 2014 Jul 31;158(3):549-63. (PMID: 25042851); J Mol Biol. 2008 Mar 14;377(1):162-80. (PMID: 18241885); PLoS One. 2012;7(7):e39210. (PMID: 22815701); Nat Cell Biol. 2000 Sep;2(9):601-8. (PMID: 10980700); Cell. 2016 Aug 11;166(4):935-949. (PMID: 27477512); Mol Cell. 2010 Aug 13;39(3):477-84. (PMID: 20655260); Int J Cell Biol. 2012;2012:208014. (PMID: 22654911); Cell. 2009 Apr 3;137(1):133-45. (PMID: 19345192); J Biol Chem. 2007 Dec 21;282(51):37276-84. (PMID: 17954934); Cell. 2016 Feb 25;164(5):1074-1074.e1. (PMID: 26919436); Mol Biol Cell. 2009 Mar;20(5):1478-92. (PMID: 19144827); Cell Div. 2007 Mar 13;2:11. (PMID: 17355622); Cancer Cell. 2014 Jul 14;26(1):106-20. (PMID: 25026213); PLoS One. 2013 Sep 27;8(9):e76016. (PMID: 24086678); Dev Cell. 2017 Apr 10;41(1):33-46.e7. (PMID: 28399398); Sci Rep. 2016 Jul 27;6:30443. (PMID: 27461074); Autophagy. 2008 Feb;4(2):237-9. (PMID: 18094623); Autophagy. 2010 Feb;6(2):288-9. (PMID: 20104023); J Biol Chem. 2010 Jul 16;285(29):22576-91. (PMID: 20452972); Cell Mol Life Sci. 2008 May;65(9):1390-402. (PMID: 18264803); Mol Cell Biol. 2004 Sep;24(18):8055-68. (PMID: 15340068); EMBO J. 2000 Jan 4;19(1):94-102. (PMID: 10619848); Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Jul 1;66(Pt 7):787-90. (PMID: 20606273); Biochemistry. 2002 Feb 12;41(6):1767-77. (PMID: 11827521); Autophagy. 2010 Apr;6(3):330-44. (PMID: 20168092); EMBO J. 2018 Mar 1;37(5):. (PMID: 29343546); Autophagy. 2014 Sep;10(9):1603-21. (PMID: 25046115); Autophagy. 2010 Nov;6(8):1090-106. (PMID: 20890124); Cell Mol Life Sci. 2009 Sep;66(17):2819-33. (PMID: 19468686); J Biol Chem. 2004 Mar 19;279(12):11926-36. (PMID: 14707125); J Cell Biol. 2010 Nov 1;191(3):537-52. (PMID: 21041446); EMBO J. 2009 Feb 18;28(4):359-71. (PMID: 19153599); Plant Cell. 2010 Jan;22(1):124-42. (PMID: 20086187); Trends Pharmacol Sci. 2016 Aug;37(8):672-688. (PMID: 27162137); Antioxid Redox Signal. 2016 Dec 10;25(17):953-964. (PMID: 27245349); J Biomol NMR. 2010 Jul;47(3):237-41. (PMID: 20428927); Biochem J. 2018 Apr 9;475(7):1271-1293. (PMID: 29519959); Nat Struct Biol. 1998 Dec;5(12):1042-7. (PMID: 9846873); J Biol Chem. 2006 May 12;281(19):13751-61. (PMID: 16500903); J Cell Sci. 2004 Aug 15;117(Pt 18):4239-51. (PMID: 15292400); Mol Biol Cell. 2008 Sep;19(9):3625-37. (PMID: 18562697); Curr Opin Struct Biol. 2017 Apr;43:10-17. (PMID: 27723509); Cell. 1999 Mar 5;96(5):635-44. (PMID: 10089879); Elife. 2015 Sep 28;4:e08941. (PMID: 26413874); Biochem Biophys Res Commun. 2002 Aug 30;296(4):813-9. (PMID: 12200120); Mol Cell Biol. 2002 Jul;22(13):4902-13. (PMID: 12052895); Mol Cell Biol. 1993 Dec;13(12):7757-65. (PMID: 8246991); Nature. 2015 Aug 20;524(7565):309-314. (PMID: 26266977); J Cell Biol. 1998 Dec 28;143(7):1883-98. (PMID: 9864362); Trends Cell Biol. 2010 Jul;20(7):391-401. (PMID: 20427185); J Biol Chem. 2017 May 5;292(18):7452-7461. (PMID: 28298444); Mol Cells. 2017 Jul 31;40(7):441-449. (PMID: 28743182); FEBS J. 2016 Oct;283(19):3534-3555. (PMID: 26991113); Autophagy. 2015 Apr 3;11(4):685-700. (PMID: 25484089); J Biol Chem. 2008 Aug 22;283(34):23305-14. (PMID: 18534977); J Mol Biol. 2007 Jan 26;365(4):1093-101. (PMID: 17098253); J Cell Biol. 1996 Jun;133(6):1331-46. (PMID: 8682868); Annu Rev Biochem. 2012;81:291-322. (PMID: 22482907); J Biol Chem. 2011 Oct 14;286(41):35663-74. (PMID: 21862579); Proc Natl Acad Sci U S A. 2000 Aug 29;97(18):10077-82. (PMID: 10963670); J Biol Chem. 2008 Jan 18;283(3):1437-44. (PMID: 18006506); FEBS Lett. 2009 Jun 18;583(12):1846-52. (PMID: 19427866); Acta Pharmacol Sin. 2013 May;34(5):585-94. (PMID: 23474706); Plant Signal Behav. 2016 Jun 2;11(6):e1175699. (PMID: 27128431); EMBO Rep. 2001 Oct;2(10):933-8. (PMID: 11571271); Biochim Biophys Acta. 2014 Nov;1843(11):2765-74. (PMID: 25110345); EMBO Rep. 2006 Dec;7(12):1252-8. (PMID: 17082820); Nat Cell Biol. 2005 Aug;7(8):742-9. (PMID: 16056265) |
| Grant Information: | R01 DK041737 United States DK NIDDK NIH HHS |
| Contributed Indexing: | Keywords: protein quality control; proteostasis; selective autophagy; ubiquitin-proteasome system; ubiquitination |
| Substance Nomenclature: | 0 (Ubiquitin); 0 (Ubiquitinated Proteins); EC 2.3.2.23 (Ubiquitin-Protein Ligase Complexes); EC 3.4.25.1 (Proteasome Endopeptidase Complex) |
| Entry Date(s): | Date Created: 20190113 Date Completed: 20191209 Latest Revision: 20200309 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC6357184 |
| DOI: | 10.3390/cells8010040 |
| PMID: | 30634694 |
| Database: | MEDLINE |
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review