Aberrations of anterior insular cortex functional connectivity in nontreatment-seeking alcoholics.
| Title: | Aberrations of anterior insular cortex functional connectivity in nontreatment-seeking alcoholics. |
|---|---|
| Authors: | Halcomb ME; Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA; Indiana University Center for Neuroimaging, Indiana University School of Medicine, Indianapolis, IN, USA; Department of Neurology, Indiana University School of Medicine, Indianapolis, IN, USA.; Chumin EJ; Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA; Indiana University Center for Neuroimaging, Indiana University School of Medicine, Indianapolis, IN, USA; Stark Neurosciences Research Institute, Indiana University School of Medicine, Indiananpolis, IN, USA; Department of Neurology, Indiana University School of Medicine, Indianapolis, IN, USA.; Goñi J; Purdue Institute for Integrative Neuroscience, Purdue University, West Lafayette, IN, USA.; Department of Neurology, Indiana University School of Medicine, Indianapolis, IN, USA.; Dzemidzic M; Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA; Indiana University Center for Neuroimaging, Indiana University School of Medicine, Indianapolis, IN, USA; Department of Neurology, Indiana University School of Medicine, Indianapolis, IN, USA.; Yoder KK; Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA; Indiana University Center for Neuroimaging, Indiana University School of Medicine, Indianapolis, IN, USA; Stark Neurosciences Research Institute, Indiana University School of Medicine, Indiananpolis, IN, USA; Department of Neurology, Indiana University School of Medicine, Indianapolis, IN, USA; Department of Psychology, Indiana University Purdue University Indianapolis, Indianapolis, IN, USA. Electronic address: kkyoder@iupui.edu. |
| Source: | Psychiatry research. Neuroimaging [Psychiatry Res Neuroimaging] 2019 Feb 28; Vol. 284, pp. 21-28. Date of Electronic Publication: 2019 Jan 02. |
| Publication Type: | Journal Article; Research Support, N.I.H., Extramural |
| Language: | English |
| Journal Info: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101723001 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7506 (Electronic) Linking ISSN: 09254927 NLM ISO Abbreviation: Psychiatry Res Neuroimaging Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Amsterdam : Elsevier |
| MeSH Terms: | Magnetic Resonance Imaging*/methods; Alcohol Drinking/*physiopathology ; Alcoholism/*physiopathology ; Cerebral Cortex/*diagnostic imaging ; Patient Acceptance of Health Care/*psychology; Alcoholism/diagnostic imaging ; Brain/physiopathology ; Cerebral Cortex/physiopathology ; Frontal Lobe/physiopathology ; Parietal Lobe/physiopathology ; Temporal Lobe/physiopathology ; Adult ; Female ; Humans ; Male |
| Abstract: | An emergent literature suggests that resting state functional magnetic resonance imaging (rsfMRI) functional connectivity (FC) patterns are aberrant in alcohol use disorder (AUD) populations. The salience network (SAL) is an established set of brain regions prominent in salience attribution and valuation, and includes the anterior insular cortex (AIC). The SAL is thought to play a role in AUD through directing increased attention to interoceptive cues of intoxication. There is very little information on the salience network (SAL) in AUD, and, in particular, there are no data on SAL FC in currently drinking, nontreatment seeking individuals with AUD (NTS). rsfMRI data from 16 NTS and 21 social drinkers (SD) were compared using FC correlation maps from ten seed regions of interest in the bilateral AIC. As anticipated, SD subjects demonstrated greater insular FC with frontal and parietal regions. We also found that, compared to SD, NTS had higher insular FC with hippocampal and medial orbitofrontal regions. The apparent overactivity in brain networks involved in salience, learning, and behavioral control in NTS suggests possible mechanisms in the development and maintenance of AUD.; (Copyright © 2019 Elsevier B.V. All rights reserved.) |
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| Grant Information: | UL1 TR002529 United States TR NCATS NIH HHS; P60 AA007611 United States AA NIAAA NIH HHS; F31 AA025518 United States AA NIAAA NIH HHS; T32 AA007462 United States AA NIAAA NIH HHS; TL1 TR001107 United States TR NCATS NIH HHS; R01 AA018354 United States AA NIAAA NIH HHS; R21 AA022650 United States AA NIAAA NIH HHS |
| Contributed Indexing: | Keywords: Alcohol use disorder; Alcoholism; Hippocampus; Interoception; Orbitofrontal cortex; Resting state functional magnetic resonance imaging; Salience network |
| Entry Date(s): | Date Created: 20190115 Date Completed: 20200206 Latest Revision: 20210814 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC6668713 |
| DOI: | 10.1016/j.pscychresns.2018.12.016 |
| PMID: | 30640144 |
| Database: | MEDLINE |
Journal Article; Research Support, N.I.H., Extramural