Neuronanomedicine: An Up-to-Date Overview.
| Title: | Neuronanomedicine: An Up-to-Date Overview. |
|---|---|
| Authors: | Teleanu DM; Emergency University Hospital, 'Carol Davila' University of Medicine and Pharmacy, 050474 Bucharest, Romania. daniel.teleanu@umfcd.ro.; Chircov C; Faculty of Engineering in Foreign Languages, University Politehnica of Bucharest, 060042 Bucharest, Romania. cristina.chircov@yahoo.com.; Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, Politehnica University of Bucharest, 060042Bucharest, Romania. cristina.chircov@yahoo.com.; Grumezescu AM; Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, Politehnica University of Bucharest, 060042Bucharest, Romania. grumezescu@yahoo.com.; ICUB-Research Institute of University of Bucharest, University of Bucharest, 36-46 M. Kogalniceanu Blvd., 050107 Bucharest, Romania. grumezescu@yahoo.com.; Teleanu RI; 'Dr. Victor Gomoiu' Clinical Children's Hospital, 'Carol Davila' University of Medicine and Pharmacy, 050474 Bucharest, Romania. raluca.teleanu@umfcd.ro. |
| Source: | Pharmaceutics [Pharmaceutics] 2019 Feb 26; Vol. 11 (3). Date of Electronic Publication: 2019 Feb 26. |
| Publication Type: | Journal Article; Review |
| Language: | English |
| Journal Info: | Publisher: MDPI Country of Publication: Switzerland NLM ID: 101534003 Publication Model: Electronic Cited Medium: Print ISSN: 1999-4923 (Print) Linking ISSN: 19994923 NLM ISO Abbreviation: Pharmaceutics Subsets: PubMed not MEDLINE |
| Imprint Name(s): | Original Publication: Basel, Switzerland : MDPI |
| Abstract: | The field of neuronanomedicine has recently emerged as the bridge between neurological sciences and nanotechnology. The possibilities of this novel perspective are promising for the diagnosis and treatment strategies of severe central nervous system disorders. Therefore, the development of nano-vehicles capable of permeating the blood⁻brain barrier (BBB) and reaching the brain parenchyma may lead to breakthrough therapies that could improve life expectancy and quality of the patients diagnosed with brain disorders. The aim of this review is to summarize the recently developed organic, inorganic, and biological nanocarriers that could be used for the delivery of imaging and therapeutic agents to the brain, as well as the latest studies on the use of nanomaterials in brain cancer, neurodegenerative diseases, and stroke. Additionally, the main challenges and limitations associated with the use of these nanocarriers are briefly presented. |
| Competing Interests: | The authors declare no conflict of interest. |
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| Contributed Indexing: | Keywords: central nervous system disorders; delivery of imaging and therapeutic agents; inorganic nanocarriers; nano-vehicles; nanotechnology; neurological sciences; neuronanomedicine; organic nanocarriers |
| Entry Date(s): | Date Created: 20190301 Latest Revision: 20231011 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC6471564 |
| DOI: | 10.3390/pharmaceutics11030101 |
| PMID: | 30813646 |
| Database: | MEDLINE |
Journal Article; Review