Association of systemic beta-defensin-1 and -20G/A DEFB1 gene polymorphism with Behçet's disease.
| Title: | Association of systemic beta-defensin-1 and -20G/A DEFB1 gene polymorphism with Behçet's disease. |
|---|---|
| Authors: | Kallel A; University of Tunis El Manar, Faculty of Medicine of Tunis, LR99ES11 Tunis, Tunisia; Rabta Hospital, Laboratory of Biochemistry, Jebbari 1007, Tunis, Tunisia.; Ben Salem T; University of Tunis El Manar, Faculty of Medicine of Tunis, LR99ES11 Tunis, Tunisia; Rabta Hospital, Service of Internal Medicine, Jebbari 1007, Tunis, Tunisia.; Hammami MB; University of Tunis El Manar, Faculty of Medicine of Tunis, LR99ES11 Tunis, Tunisia; Rabta Hospital, Laboratory of Biochemistry, Jebbari 1007, Tunis, Tunisia.; Said F; University of Tunis El Manar, Faculty of Medicine of Tunis, LR99ES11 Tunis, Tunisia; Rabta Hospital, Service of Internal Medicine, Jebbari 1007, Tunis, Tunisia.; Jemaa R; University of Tunis El Manar, Faculty of Medicine of Tunis, LR99ES11 Tunis, Tunisia; Rabta Hospital, Laboratory of Biochemistry, Jebbari 1007, Tunis, Tunisia.; Houman MH; University of Tunis El Manar, Faculty of Medicine of Tunis, LR99ES11 Tunis, Tunisia; Rabta Hospital, Service of Internal Medicine, Jebbari 1007, Tunis, Tunisia.; Feki M; University of Tunis El Manar, Faculty of Medicine of Tunis, LR99ES11 Tunis, Tunisia; Rabta Hospital, Laboratory of Biochemistry, Jebbari 1007, Tunis, Tunisia.. Electronic address: monssef.feki@gmail.com. |
| Source: | European journal of internal medicine [Eur J Intern Med] 2019 Jul; Vol. 65, pp. 58-62. Date of Electronic Publication: 2019 Feb 26. |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 9003220 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0828 (Electronic) Linking ISSN: 09536205 NLM ISO Abbreviation: Eur J Intern Med Subsets: MEDLINE |
| Imprint Name(s): | Publication: 1999- : Amsterdam, The Netherlands : Elsevier Science; Original Publication: Basingstoke, Hampshire, UK : Published by the Macmillan Press on behalf of the European Association of Internal Medicine, c1989- |
| MeSH Terms: | Behcet Syndrome/*genetics ; beta-Defensins/*genetics; Adult ; Case-Control Studies ; Female ; Genetic Predisposition to Disease ; Humans ; Logistic Models ; Male ; Middle Aged ; Polymorphism, Single Nucleotide ; Tunisia |
| Abstract: | Background: Behçet's disease (BD) is a multisystem inflammatory disease of unknown etiology. Beta-defensins are antimicrobial peptides involved in epithelial host defense. To explore whether beta-defensins might be involved in BD pathogenesis, we examined plasma human beta-defensin-1 (hBD-1) and DEFB1 -20G/A polymorphism in BD patients.; Methods: This case-control study included 106 BD patients fulfilling the criteria of the International Study Group for BD and 156 controls. The -20G/A genotypes were determined by PCR-RFLP analysis in all participants, and plasma hBD-1 was assessed by ELISA in 77 BD patients and 44 controls, only. Stepwise multiple regression models were applied to determine independent predictors for plasma hBD-1 in BD patients.; Results: Distribution of -20G/A genotypes was different between BD patients and controls. Compared to GG genotype, "GA" genotype [OR (95% CI), 3.12 (1.56-6.16); p = .001] and "AA" genotype [2.57 (1.10-5.96); p = .027)] were associated with increased risk for BD. Plasma hBD-1 concentrations were significantly higher in BD patients than controls (9.81 ± 3.52 ng/mL vs. 5.30 ± 3.02 ng/mL; p |
| Contributed Indexing: | Keywords: Behcet's disease; Beta-defensin-1; DEFB1 gene; Oral aphtosis; Single-nucleotide polymorphism |
| Substance Nomenclature: | 0 (DEFB1 protein, human); 0 (beta-Defensins) |
| Entry Date(s): | Date Created: 20190302 Date Completed: 20200915 Latest Revision: 20200915 |
| Update Code: | 20260130 |
| DOI: | 10.1016/j.ejim.2019.02.008 |
| PMID: | 30819604 |
| Database: | MEDLINE |
Journal Article