Comparing the Effect of Clonidine and Dexmedetomidine on Intraoperative Bleeding in Spine Surgery.
| Title: | Comparing the Effect of Clonidine and Dexmedetomidine on Intraoperative Bleeding in Spine Surgery. |
|---|---|
| Authors: | Janatmakan F; Department of Anesthesia, Pain Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.; Nesioonpour S; Department of Anesthesia, Pain Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.; Javaherforoosh Zadeh F; Department of Anesthesia, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.; Teimouri A; Department of Neurosurgery, Tehran Medical Science Branch, Islamic Azad University Tehran, Iran.; Vaziri M; Department of Anesthesia, Pain Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. |
| Source: | Anesthesiology and pain medicine [Anesth Pain Med] 2019 Feb 24; Vol. 9 (1), pp. e83967. Date of Electronic Publication: 2019 Feb 24 (Print Publication: 2019). |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: Brieflands Country of Publication: Netherlands NLM ID: 101585412 Publication Model: eCollection Cited Medium: Print ISSN: 2228-7523 (Print) Linking ISSN: 22287523 NLM ISO Abbreviation: Anesth Pain Med Subsets: PubMed not MEDLINE |
| Imprint Name(s): | Publication: 's-Hertogenbosch, The Netherlands : Brieflands; Original Publication: Hoensbroek, Limburg : Kowsar Corp. |
| Abstract: | Background: Discopathy is one of the most common spinal surgeries. Hemodynamic control is important in bleeding reduction during the surgery. Clonidine and dexmedetomidine both are α2 agonists that help stabilize hemodynamics and prevent the increase of intraoperative bleeding.; Objectives: In this study, the effects of clonidine and dexmedetomidine were compared in bleeding reduction during spinal surgery.; Methods: This randomized, double-blind clinical trial was conducted in 120 patients aged 20 to 50 years with ASA class I or II, undergoing spinal surgery. Patients were randomly divided into three groups. Group C received oral clonidine 0.2 mg, 90 minutes before entering the room. Group D received dexmedetomidine 0.5 µ/kg 15 minutes before anesthesia induction and 0.25 µ/kg/h infusion during operation. Group P received placebo as the control group.; Results: There was a significant reduction in intraoperative blood loss in patients who received clonidine (289 ± 130) and dexmedetomidine (344 ± 145) compared to the control group (462 ± 15) (P < 0.05), with a more dramatic reduction in the clonidine group (P < 0. 001). |
| References: | Am J Med. 2003 Jun 15;114(9):742-52. (PMID: 12829201); Spine (Phila Pa 1976). 2003 Nov 1;28(21):2482-5. (PMID: 14595168); Eur Spine J. 2004 Oct;13 Suppl 1:S18-27. (PMID: 15480823); J Clin Anesth. 2008 Sep;20(6):437-41. (PMID: 18929284); Middle East J Anaesthesiol. 2013 Feb;22(1):27-33. (PMID: 23833847); Anesth Pain Med. 2012 Spring;1(4):252-6. (PMID: 24904810); Anesth Pain Med. 2011 Jul;1(1):30-3. (PMID: 25729653); Med J Islam Repub Iran. 2015 Jun 06;29:215. (PMID: 26478873); Anesth Pain Med. 2018 Apr 28;8(2):e66959. (PMID: 30009153) |
| Contributed Indexing: | Keywords: Blood Loss; Clonidine; Dexmedetomidine; Hemodynamic; Spine Surgery |
| Entry Date(s): | Date Created: 20190319 Latest Revision: 20220408 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC6408748 |
| DOI: | 10.5812/aapm.83967 |
| PMID: | 30881906 |
| Database: | MEDLINE |
Journal Article