Cerebrolysin improves peripheral inflammatory pain: Sex differences in two models of acute and chronic mechanical hypersensitivity.
| Title: | Cerebrolysin improves peripheral inflammatory pain: Sex differences in two models of acute and chronic mechanical hypersensitivity. |
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| Authors: | Morales-Medina JC; Centro de Investigación en Reproducción Animal, CINVESTAV- Universidad Autónoma de Tlaxcala, Tlaxcala, Mexico.; Flores G; Laboratorio Neuropsiquiatría. Instituto de Fisiología, Benemérita Universidad Autónoma de Puebla, Puebla, Mexico.; Vallelunga A; Department of Medicine and Surgery, Centre for Neurodegenerative Diseases (CEMAND), University of Salerno, Salerno, Italy.; Griffiths NH; Laboratorio Neuropsiquiatría. Instituto de Fisiología, Benemérita Universidad Autónoma de Puebla, Puebla, Mexico.; Iannitti T; KWS BioTest, Department of Pharmacology, Portishead, Somerset, UK. |
| Source: | Drug development research [Drug Dev Res] 2019 Jun; Vol. 80 (4), pp. 513-518. Date of Electronic Publication: 2019 Mar 25. |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: Wiley-Liss Country of Publication: United States NLM ID: 8204468 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-2299 (Electronic) Linking ISSN: 02724391 NLM ISO Abbreviation: Drug Dev Res Subsets: MEDLINE |
| Imprint Name(s): | Publication: New York Ny : Wiley-Liss; Original Publication: New York : Alan R. Liss, c1981- |
| MeSH Terms: | Sex Characteristics*; Acute Pain/*drug therapy ; Amino Acids/*therapeutic use ; Chronic Pain/*drug therapy ; Edema/*drug therapy ; Hyperalgesia/*drug therapy ; Neuroprotective Agents/*therapeutic use; Acute Pain/immunology ; Chronic Pain/immunology ; Edema/immunology ; Hyperalgesia/immunology ; Animals ; Carrageenan ; Disease Models, Animal ; Female ; Freund's Adjuvant ; Inflammation ; Male ; Pain Measurement ; Rats, Wistar ; Time Factors |
| Abstract: | Chronic inflammatory pain is a major health problem worldwide with high prevalence in women. Cerebrolysin is a multimodal neuropeptide preparation that crosses the blood brain barrier and displays neuroprotective properties in aging and disease. Previously, we showed that cerebrolysin reduced mechanical allodynia in a model of persistent inflammation and pain. We aim to build upon the findings of our previous study by investigating the response to acute administration of cerebrolysin in two models of peripheral inflammation and assessing sex differences. We utilized the complete Freund's adjuvant (CFA) that produces maximal oedema and mechanical allodynia within days and carrageenan that produces similar effects within hours. Cerebrolysin reversed the mechanical allodynia in both sexes in CFA-treated rats. On the other hand, in rats treated with carrageenan, cerebrolysin was only effective in reducing mechanical allodynia in female rats. In conclusion, the present study shows that cerebrolysin effects may be sex-specific depending on different mechanisms that are at play in these two models of peripheral inflammatory pain. Further investigations are required to determine the factors contributing to sex differences.; (© 2019 Wiley Periodicals, Inc.) |
| Contributed Indexing: | Keywords: CFA; allodynia; carrageenan; cerebrolysin; hypersensitivity; neuropeptide; pain; peripheral inflammation; peripheral pain; sex differences |
| Substance Nomenclature: | 0 (Amino Acids); 0 (Neuroprotective Agents); 37KZM6S21G (cerebrolysin); 9000-07-1 (Carrageenan); 9007-81-2 (Freund's Adjuvant) |
| Entry Date(s): | Date Created: 20190326 Date Completed: 20200117 Latest Revision: 20200117 |
| Update Code: | 20260130 |
| DOI: | 10.1002/ddr.21528 |
| PMID: | 30908710 |
| Database: | MEDLINE |
Journal Article