Neutrophil to Lymphocyte Ratio is Useful in Differentiation of Malign and Benign Thyroid Nodules.
| Title: | Neutrophil to Lymphocyte Ratio is Useful in Differentiation of Malign and Benign Thyroid Nodules. |
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| Authors: | Sit M; Abant Izzet Baysal University Hospital, Bolu, Turkey.; Aktas G; Abant Izzet Baysal University Hospital, Bolu, Turkey.; Erkol H; Abant Izzet Baysal University Hospital, Bolu, Turkey.; Yaman S; Abant Izzet Baysal University Hospital, Bolu, Turkey.; Keyif F; Abant Izzet Baysal University Hospital, Bolu, Turkey.; Savli H; Abant Izzet Baysal University Hospital, Bolu, Turkey. |
| Source: | Puerto Rico health sciences journal [P R Health Sci J] 2019 Mar; Vol. 38 (1), pp. 60-63. |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: University of Puerto Rico Medical Sciences Campus Country of Publication: Puerto Rico NLM ID: 8303541 Publication Model: Print Cited Medium: Internet ISSN: 2373-6011 (Electronic) Linking ISSN: 07380658 NLM ISO Abbreviation: P R Health Sci J Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: [Puerto Rico] : University of Puerto Rico Medical Sciences Campus, c1982- |
| MeSH Terms: | Carcinoma, Papillary/*pathology ; Lymphocytes/*metabolism ; Neutrophils/*metabolism ; Thyroid Neoplasms/*pathology ; Thyroid Nodule/*pathology; Carcinoma, Papillary/blood ; Goiter, Nodular/blood ; Goiter, Nodular/pathology ; Inflammation/blood ; Inflammation/pathology ; Thyroid Neoplasms/blood ; Thyroid Nodule/blood ; Adult ; Case-Control Studies ; Female ; Humans ; Male ; Middle Aged ; Retrospective Studies |
| Abstract: | Objective: Significant amount of thyroid nodules are malignant. Inflammation plays crucial role in the pathogenesis of many disorders, including cancer. Neutrophil to lymphocyte ratio (NLR), has been suggested as an index of inflammatory response and association between increased NLR and cancer has also been reported. In this retrospective analysis, we aimed to study NLR levels in patients with malign and benign thyroid nodules and healthy control subjects.; Methods: The patients who underwent surgery for nodular goiter in general surgery clinics of our university hospital between June 2012 and June 2015 and 68 healthy volunteers were included. Patients with thyroid nodules divided into malign or benign nodule groups according to the pathology report. Thyroid carcinomas other than micropapillary tumor were excluded. Preoperative hemogram parameters of these groups were compared.; Results: Mean NLR of malign nodule group (2.1±0.9%) was significantly higher than both those in benign nodule (1.7±0.9%) and control groups (1.7±0.6%).; Conclusion: We suggest that elevated NLR in patients with thyroid nodules in preoperative period may be an indicator of underlying malign nodular disease. Increased NLR in such patients should encourage physician to perform cancer screening in thyroid gland. |
| Contributed Indexing: | Keywords: Cancer; Inflammation; Neutrophil to lymphocyte ratio; Thyroid nodule |
| SCR Disease Name: | Papillary Thyroid Microcarcinoma |
| Entry Date(s): | Date Created: 20190330 Date Completed: 20200228 Latest Revision: 20200228 |
| Update Code: | 20260130 |
| PMID: | 30924917 |
| Database: | MEDLINE |
Journal Article