Perceived triggers of asthma impair quality of life in children with asthma.
| Title: | Perceived triggers of asthma impair quality of life in children with asthma. |
|---|---|
| Authors: | Kansen HM; Department of Pediatric Pulmonology and Allergology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, the Netherlands.; Department of Dermatology/Allergology, University Medical Center Utrecht, Utrecht, the Netherlands.; Le TM; Department of Dermatology/Allergology, University Medical Center Utrecht, Utrecht, the Netherlands.; Meijer Y; Department of Pediatric Pulmonology and Allergology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, the Netherlands.; Uiterwaal CSPM; Julius Center for Health Science and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.; Knulst AC; Department of Dermatology/Allergology, University Medical Center Utrecht, Utrecht, the Netherlands.; van der Ent CK; Department of Pediatric Pulmonology and Allergology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, the Netherlands.; van Erp FC; Department of Dermatology/Allergology, University Medical Center Utrecht, Utrecht, the Netherlands. |
| Source: | Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology [Clin Exp Allergy] 2019 Jul; Vol. 49 (7), pp. 980-989. Date of Electronic Publication: 2019 May 14. |
| Publication Type: | Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't |
| Language: | English |
| Journal Info: | Publisher: Blackwell Scientific Publications Country of Publication: England NLM ID: 8906443 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2222 (Electronic) Linking ISSN: 09547894 NLM ISO Abbreviation: Clin Exp Allergy Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Oxford : Blackwell Scientific Publications, c1989- |
| MeSH Terms: | Asthma* ; Quality of Life* ; Surveys and Questionnaires*; Adolescent ; Child ; Female ; Humans ; Male |
| Abstract: | Background: Data on the impact of the number and nature of perceived asthma triggers on health-related quality of life (HRQL) in children are scarce.; Objective: To investigate the impact of perceived asthma triggers on both asthma-specific and generic HRQL in children.; Methods: A cross-sectional study was conducted among children (7-18 years) with asthma in secondary and tertiary care. Children were screened with electronic questionnaires regarding respiratory and allergic symptoms. Asthma-specific HRQL was assessed using the Pediatric Asthma Quality of Life Questionnaire (PAQLQ) (score range 1-7) and generic HRQL using the RAND questionnaire (score range 7-32). The Kruskal-Wallis test and one-way ANOVA were used to test the difference of, respectively, the PAQLQ and RAND scores across the number of perceived asthma triggers (0, 1-2, 3-4, or ≥ 5). Univariable and multivariable linear regression analyses were performed to evaluate the association between individual triggers and HRQL.; Results: A total of 527 children with a mean (SD) age of 12.1 (2.9) years were included. Children with a higher number of perceived triggers had significantly lower PAQLQ and RAND scores (ie poorer HRQL). The difference in PAQLQ scores was clinically relevant between children with 0 versus 3-4 or ≥ 5 triggers and 1-2 versus ≥ 5 triggers (mean difference 0.66, 1.02 and 0.63, respectively). Especially, non-allergic triggers (physical exercise, the weather, (cigarette) smoke and emotions) were significantly associated with reduced PAQLQ scores. Emotions and food/drinks were associated with reduced RAND scores.; Conclusion and Clinical Relevance: A higher number of perceived triggers of asthma were associated with reduced HRQL in children with asthma. Especially, non-allergic triggers were associated with reduced HRQL.; (© 2019 The Authors. Clinical & Experimental Allergy Published by John Wiley & Sons Ltd.) |
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| Contributed Indexing: | Keywords: asthma; paediatrics; quality of life |
| Entry Date(s): | Date Created: 20190501 Date Completed: 20200820 Latest Revision: 20210109 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC6851977 |
| DOI: | 10.1111/cea.13407 |
| PMID: | 31038823 |
| Database: | MEDLINE |
Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't