Effects on cognition of 20-day anodal transcranial direct current stimulation over the left dorsolateral prefrontal cortex in patients affected by mild cognitive impairment: a case-control study.
| Title: | Effects on cognition of 20-day anodal transcranial direct current stimulation over the left dorsolateral prefrontal cortex in patients affected by mild cognitive impairment: a case-control study. |
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| Authors: | Fileccia E; Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy. enrico.fileccia@studio.unibo.it.; Di Stasi V; Institute of Neurological Sciences of Bologna, Bologna, Italy.; Poda R; Institute of Neurological Sciences of Bologna, Bologna, Italy.; Rizzo G; Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.; Institute of Neurological Sciences of Bologna, Bologna, Italy.; Stanzani-Maserati M; Institute of Neurological Sciences of Bologna, Bologna, Italy.; Oppi F; Institute of Neurological Sciences of Bologna, Bologna, Italy.; Avoni P; Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.; Institute of Neurological Sciences of Bologna, Bologna, Italy.; Capellari S; Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.; Institute of Neurological Sciences of Bologna, Bologna, Italy.; Liguori R; Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.; Institute of Neurological Sciences of Bologna, Bologna, Italy. |
| Source: | Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology [Neurol Sci] 2019 Sep; Vol. 40 (9), pp. 1865-1872. Date of Electronic Publication: 2019 May 07. |
| Publication Type: | Journal Article; Randomized Controlled Trial |
| Language: | English |
| Journal Info: | Publisher: Springer-Verlag Italia Country of Publication: Italy NLM ID: 100959175 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1590-3478 (Electronic) Linking ISSN: 15901874 NLM ISO Abbreviation: Neurol Sci Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Milano, Italy : Springer-Verlag Italia, c2000- |
| MeSH Terms: | Neuropsychological Tests* ; Prefrontal Cortex*; Cognitive Dysfunction/*therapy ; Transcranial Direct Current Stimulation/*methods; Affect/physiology ; Pattern Recognition, Visual/physiology ; Aged ; Case-Control Studies ; Female ; Follow-Up Studies ; Humans ; Language ; Male ; Memory, Episodic ; Treatment Outcome |
| Abstract: | Background: Mild cognitive impairment (MCI) is a common disorder affecting as much as 15% of the elderly population. Transcranial direct current stimulation (tDCS) is a non-invasive technique of neuromodulation that has proven to influence performance in different cognitive domains.; Objective/hypothesis: We investigated the effects on cognition of 20-day anodal tDCS in 17 MCI patients compared with 17 matched MCI patients.; Methods: Patients underwent neuropsychological evaluation at baseline and then were randomly assigned to the anodal or sham group. The tDCS protocol consisted in 20 min, 5 days per week (up to a total of 20 days), of 2-mA anodal stimulation over the left dorsolateral prefrontal cortex (DLPFC). The location of anodal electrode was chosen in accordance with previous reports which relate anodal stimulation of this site with cognitive enhancement. At the end of the last day of stimulation, a second neuropsychological evaluation was performed. We compared baseline and post-stimulation neuropsychological results in the anodal vs sham group using repeated measures ANOVA as a statistical analysis test.; Results: At follow-up, patients exposed to anodal stimulation showed improvement in episodic verbal memory (p |
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| Contributed Indexing: | Keywords: Cognition; DLPFC; MCI; Mild cognitive impairment; Neuropsychology; Transcranial direct current stimulation; tDCS |
| Entry Date(s): | Date Created: 20190508 Date Completed: 20200212 Latest Revision: 20200225 |
| Update Code: | 20260130 |
| DOI: | 10.1007/s10072-019-03903-6 |
| PMID: | 31062189 |
| Database: | MEDLINE |
Journal Article; Randomized Controlled Trial