Lineage specific histories of Mycobacterium tuberculosis dispersal in Africa and Eurasia.
| Title: | Lineage specific histories of Mycobacterium tuberculosis dispersal in Africa and Eurasia. |
|---|---|
| Authors: | O'Neill MB; Laboratory of Genetics, University of Wisconsin-Madison, Madison, WI, USA.; Department of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, WI, USA.; Shockey A; Department of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, WI, USA.; Zarley A; Department of Geography, University of Wisconsin-Madison, Madison, WI, USA.; Aylward W; Department of Classical and Ancient Near Eastern Studies, University of Wisconsin-Madison, Madison, WI, USA.; Eldholm V; Infection Control and Environmental Health, Norwegian Institute of Public Health, Oslo, Norway.; Kitchen A; Department of Anthropology, University of Iowa, Iowa City, IA, USA.; Pepperell CS; Department of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, WI, USA.; Department of Medicine, University of Wisconsin-Madison, Madison, WI, USA. |
| Source: | Molecular ecology [Mol Ecol] 2019 Jul; Vol. 28 (13), pp. 3241-3256. Date of Electronic Publication: 2019 Jul 09. |
| Publication Type: | Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S. |
| Language: | English |
| Journal Info: | Publisher: Blackwell Scientific Publications Country of Publication: England NLM ID: 9214478 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-294X (Electronic) Linking ISSN: 09621083 NLM ISO Abbreviation: Mol Ecol Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Oxford, UK : Blackwell Scientific Publications, c1992- |
| MeSH Terms: | Evolution, Molecular* ; Genetics, Population*; Mycobacterium tuberculosis/*genetics; Africa, Eastern ; Asia ; Bayes Theorem ; Europe ; Genome, Bacterial ; Human Migration ; Humans ; Likelihood Functions ; Phylogeography ; Polymorphism, Single Nucleotide |
| Abstract: | Mycobacterium tuberculosis (M.tb) is a globally distributed, obligate pathogen of humans that can be divided into seven clearly defined lineages. An emerging consensus places the origin and global dispersal of M.tb within the past 6,000 years: identifying how the ancestral clone of M.tb spread and differentiated within this timeframe is important for identifying the ecological drivers of the current pandemic. We used Bayesian phylogeographic inference to reconstruct the migratory history of M.tb in Africa and Eurasia and to investigate lineage specific patterns of spread from a geographically diverse sample of 552 M.tb genomes. Applying evolutionary rates inferred with ancient M.tb genome calibration, we estimated the timing of major events in the migratory history of the pathogen. Inferred timings contextualize M.tb dispersal within historical phenomena that altered patterns of connectivity throughout Africa and Eurasia: trans-Indian Ocean trade in spices and other goods, the Silk Road and its predecessors, the expansion of the Roman Empire, and the European Age of Exploration. We found that Eastern Africa and Southeast Asia have been critical in the dispersal of M.tb. Our results further reveal that M.tb populations have grown through range expansion, as well as in situ, and delineate the independent evolutionary trajectories of bacterial subpopulations underlying the current pandemic.; (© 2019 The Authors Molecular Ecology Published by John Wiley & Sons Ltd.) |
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| Grant Information: | R01 AI113287 United States AI NIAID NIH HHS; T32 GM007133 United States GM NIGMS NIH HHS |
| Contributed Indexing: | Keywords: bacteria; landscape genetics; molecular evolution; phylogeography; population dynamics; population genetics - empirical |
| Molecular Sequence: | GENBANK NC_000962.3 |
| Entry Date(s): | Date Created: 20190509 Date Completed: 20200330 Latest Revision: 20231014 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC6660993 |
| DOI: | 10.1111/mec.15120 |
| PMID: | 31066139 |
| Database: | MEDLINE |
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.