Relationship Type and Use of the Vaginal Ring for HIV-1 Prevention in the MTN 020/ASPIRE Trial.
| Title: | Relationship Type and Use of the Vaginal Ring for HIV-1 Prevention in the MTN 020/ASPIRE Trial. |
|---|---|
| Authors: | Pleasants E; RTI International, Women's Global Health Imperative, UC Berkeley SPH, 628 Beacon Street, Oakland, CA, 94610, USA. betsypleasants@gmail.com.; Tauya T; University of Zimbabwe-University of California San Francisco Collaborative Research Program (UZ-UCSF), San Francisco, CA, USA.; Reddy K; University of the Witwatersrand, Wits Reproductive Health and HIV Institute (Wits RHI), Johannesburg, South Africa.; Mirembe BG; Makerere University - Johns Hopkins University Research Collaboration (MU-JHU), Kampala, Uganda.; Woeber K; South African Medical Research Council (SAMRC), HIV Prevention Research Unit, Cape Town, South Africa.; Palanee-Phillips T; University of the Witwatersrand, Wits Reproductive Health and HIV Institute (Wits RHI), Johannesburg, South Africa.; Zimba C; UNC Project, Tidziwe Centre, Lilongwe, Malawi.; Kamuzu Central Hospital, Lilongwe, Malawi.; Atujuna M; The Desmond Tutu HIV Foundation, Desmond Tutu HIV Centre (DTHC) at the University of Cape Town, Cape Town, South Africa.; Montgomery ET; RTI International, Women's Global Health Imperative, UC Berkeley SPH, 628 Beacon Street, Oakland, CA, 94610, USA. |
| Corporate Authors: | MTN-020/ASPIRE Study Team |
| Source: | AIDS and behavior [AIDS Behav] 2020 Mar; Vol. 24 (3), pp. 866-880. |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: Springer Science + Business Media Country of Publication: United States NLM ID: 9712133 Publication Model: Print Cited Medium: Internet ISSN: 1573-3254 (Electronic) Linking ISSN: 10907165 NLM ISO Abbreviation: AIDS Behav Subsets: MEDLINE |
| Imprint Name(s): | Publication: 2005- : New York, NY : Springer Science + Business Media; Original Publication: New York, NY : Plenum Press, 1997- |
| MeSH Terms: | Interpersonal Relations*; Anti-HIV Agents/*administration & dosage ; Contraceptive Devices, Female/*statistics & numerical data ; HIV Infections/*prevention & control ; Pre-Exposure Prophylaxis/*methods ; Pyrimidines/*administration & dosage ; Sexual Partners/*psychology; Anti-HIV Agents/therapeutic use ; Administration, Intravaginal ; Adolescent ; Adult ; Clinical Trials as Topic ; Female ; HIV-1 ; Humans ; Malawi ; Male ; Middle Aged ; Qualitative Research ; Sexual Behavior ; South Africa ; Uganda ; Vaginal Creams, Foams, and Jellies ; Zimbabwe |
| Abstract: | Gender roles and imbalances in sexual power contribute to the heightened HIV-1 risk faced by women in Sub-Saharan Africa. This has led prevention research to focus on the development of female controlled methods. Despite the design of products such as vaginal rings to be used autonomously by women, male partners and women's perceptions of relationships influence HIV prevention choices. To understand the influences that male partners and dyadic dynamics had on the use of the Dapivirine Vaginal Ring in the ASPIRE trial, this analysis of qualitative data explored the types of intimate partner relationships that women engaged in. This paper describes how partners facilitated or challenged women's ring use and how women dealt with these challenges within six different types of relationships characterized by power dynamics and commitment levels. We offer insights into how future use of female-initiated HIV prevention products can be promoted through recognition of different relationship types. |
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| Grant Information: | UM1 AI069423 United States AI NIAID NIH HHS; UM1 AI068633 United States AI NIAID NIH HHS; UM1AI106707 National Institute of Allergy and Infectious Diseases; UM1 AI068615 United States AI NIAID NIH HHS; UM1AI068633 National Institute of Allergy and Infectious Diseases; UM1 AI069530 United States AI NIAID NIH HHS; UM1 AI069518 United States AI NIAID NIH HHS; UM1 AI069463 United States AI NIAID NIH HHS; D43 TW001081 United States TW FIC NIH HHS; UM1AI068615 National Institute of Allergy and Infectious Diseases; UM1 AI106707 United States AI NIAID NIH HHS |
| Contributed Indexing: | Investigator: J Baeten; T Palanee-Phillips; E Brown; L Soto-Torres; B Makanani; F Martinson; LG Bekker; V Govender; S Siva; Z Gaffoor; L Naidoo; A Pather; N Jeenarain; G Nair; F Matovu; N Mgodi; F Mhlanga; Keywords: Adherence; Clinical trial; Couples; Female controlled HIV prevention; Gender; Gender relations; HIV; Microbicide; Qualitative research; Sexual relationship; Sub-Saharan Africa; Vaginal ring; Women |
| Substance Nomenclature: | 0 (Anti-HIV Agents); 0 (Pyrimidines); 0 (Vaginal Creams, Foams, and Jellies); TCN4MG2VXS (Dapivirine) |
| Entry Date(s): | Date Created: 20190522 Date Completed: 20200624 Latest Revision: 20210408 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC6864230 |
| DOI: | 10.1007/s10461-019-02521-9 |
| PMID: | 31111297 |
| Database: | MEDLINE |
Journal Article