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Nanomaterial-Based Approaches for Neural Regeneration.

Title: Nanomaterial-Based Approaches for Neural Regeneration.
Authors: Teleanu RI; 'Victor Gomoiu' Clinical Children's Hospital, 'Carol Davila' University of Medicine and Pharmacy, 050474 Bucharest, Romania. raluca.teleanu@umfcd.ro.; Gherasim O; Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, Politehnica University of Bucharest, 011061 Bucharest, Romania. oana.fufa@gmail.com.; Lasers Department, National Institute for Lasers, Plasma and Radiation Physics, 077125 Magurele, Romania. oana.fufa@gmail.com.; Gherasim TG; National Institute of Neurology and Neurovascular Diseases, 077160 Bucharest, Romania. tudor.gherasim@gmail.com.; Grumezescu V; Lasers Department, National Institute for Lasers, Plasma and Radiation Physics, 077125 Magurele, Romania. valentina_grumezescu@yahoo.com.; Grumezescu AM; Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, Politehnica University of Bucharest, 011061 Bucharest, Romania. alexandru.grumezescu@upb.ro.; Teleanu DM; Emergency University Hospital, 'Carol Davila' University of Medicine and Pharmacy, 050474 Bucharest, Romania. daniel.teleanu@umfcd.ro.
Source: Pharmaceutics [Pharmaceutics] 2019 Jun 08; Vol. 11 (6). Date of Electronic Publication: 2019 Jun 08.
Publication Type: Journal Article; Review
Language: English
Journal Info: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101534003 Publication Model: Electronic Cited Medium: Print ISSN: 1999-4923 (Print) Linking ISSN: 19994923 NLM ISO Abbreviation: Pharmaceutics Subsets: PubMed not MEDLINE
Imprint Name(s): Original Publication: Basel, Switzerland : MDPI
Abstract: Mechanical, thermal, chemical, or ischemic injury of the central or peripheral nervous system results in neuron loss, neurite damage, and/or neuronal dysfunction, almost always accompanied by sensorimotor impairment which alters the patient's life quality. The regenerative strategies for the injured nervous system are currently limited and mainly allow partial functional recovery, so it is necessary to develop new and effective approaches for nervous tissue regenerative therapy. Nanomaterials based on inorganic or organic and composite or hybrid compounds with tunable physicochemical properties and functionality proved beneficial for the transport and delivery/release of various neuroregenerative-relevant biomolecules or cells. Within the following paragraphs, we will emphasize that nanomaterial-based strategies (including nanosized and nanostructured biomaterials) represent a promising alternative towards repairing and regenerating the injured nervous system.
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Contributed Indexing: Keywords: nanomaterial; nervous system injury; neuroregeneration
Entry Date(s): Date Created: 20190612 Latest Revision: 20231012
Update Code: 20260130
PubMed Central ID: PMC6630326
DOI: 10.3390/pharmaceutics11060266
PMID: 31181719
Database: MEDLINE

Journal Article; Review