Estrogen-Containing Oral Contraceptives Are Associated With Polycystic Liver Disease Severity in Premenopausal Patients.
| Title: | Estrogen-Containing Oral Contraceptives Are Associated With Polycystic Liver Disease Severity in Premenopausal Patients. |
|---|---|
| Authors: | van Aerts RMM; Department of Gastroenterology and Hepatology, Radboud University Medical Center, Nijmegen, The Netherlands.; Bernts LHP; Department of Gastroenterology and Hepatology, Radboud University Medical Center, Nijmegen, The Netherlands.; Gevers TJG; Department of Gastroenterology and Hepatology, Radboud University Medical Center, Nijmegen, The Netherlands.; Kievit W; Department for Health Evidence, Radboud University Medical Center, Nijmegen, The Netherlands.; Koopmans L; Department of Gastroenterology and Hepatology, Radboud University Medical Center, Nijmegen, The Netherlands.; Nieboer TE; Department of Obstetrics and Gynecology, Radboud University Medical Center, Nijmegen, The Netherlands.; Nevens F; Department of Gastroenterology and Hepatology, University Hospital Leuven, Leuven, Belgium.; Drenth JPH; Department of Gastroenterology and Hepatology, Radboud University Medical Center, Nijmegen, The Netherlands. |
| Source: | Clinical pharmacology and therapeutics [Clin Pharmacol Ther] 2019 Dec; Vol. 106 (6), pp. 1338-1345. Date of Electronic Publication: 2019 Jul 23. |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: Wiley Country of Publication: United States NLM ID: 0372741 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-6535 (Electronic) Linking ISSN: 00099236 NLM ISO Abbreviation: Clin Pharmacol Ther Subsets: MEDLINE |
| Imprint Name(s): | Publication: 2015- : Hoboken, NJ : Wiley; Original Publication: St. Louis : C.V. Mosby |
| MeSH Terms: | Contraceptives, Oral, Hormonal/*therapeutic use ; Cysts/*pathology ; Estrogens/*therapeutic use ; Hepatomegaly/*pathology ; Liver/*pathology ; Liver Diseases/*pathology; Cysts/complications ; Liver Diseases/complications ; Polycystic Kidney, Autosomal Dominant/complications ; Progestins/therapeutic use ; Adult ; Breast Feeding ; Female ; Gravidity ; Humans ; Menarche ; Middle Aged ; Organ Size ; Postmenopause ; Premenopause ; Reproductive History ; Risk Factors ; Severity of Illness Index |
| Abstract: | The association between estrogen-containing oral contraceptives and history of pregnancies with disease severity in women with polycystic liver disease (PLD) is unclear. We performed a cross-sectional cohort study to assess this association by selecting female patients with PLD of which imaging was available prior to any liver volume-reducing therapy. Patients received a questionnaire to collect detailed information on estrogen use and pregnancies. Preplanned subgroup analyses were performed on premenopausal and postmenopausal patients. The questionnaire was returned by 287 of 360 selected patients (80%). There was no significant association between estrogen-containing oral contraceptives and height-adjusted total liver volume (hTLV) in the total group (P = 0.06) and postmenopausal subgroup (P = 0.7). By contrast, each year of exposure corresponds with a 1.45% higher hTLV (P = 0.02) in the premenopausal subgroup, equivalent to a 15.5% higher hTLV for every 10 years of use. Pregnancy duration was not associated with hTLV. In conclusion, patients with PLD should avoid exogenous estrogens.; (© 2019 The Authors Clinical Pharmacology & Therapeutics published by Wiley Periodicals, Inc. on behalf of American Society for Clinical Pharmacology and Therapeutics.) |
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| Substance Nomenclature: | 0 (Contraceptives, Oral, Hormonal); 0 (Estrogens); 0 (Progestins) |
| SCR Disease Name: | Polycystic liver disease |
| Entry Date(s): | Date Created: 20190618 Date Completed: 20200604 Latest Revision: 20200604 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC6896230 |
| DOI: | 10.1002/cpt.1553 |
| PMID: | 31206615 |
| Database: | MEDLINE |
Journal Article