Mechanistic Insights into the Role of Atg11 in Selective Autophagy.
| Title: | Mechanistic Insights into the Role of Atg11 in Selective Autophagy. |
|---|---|
| Authors: | Zientara-Rytter K; Section of Molecular Biology, Division of Biological Sciences, University of California San Diego, La Jolla, CA 92093, USA. Electronic address: kzientararytter@ucsd.edu.; Subramani S; Section of Molecular Biology, Division of Biological Sciences, University of California San Diego, La Jolla, CA 92093, USA. |
| Source: | Journal of molecular biology [J Mol Biol] 2020 Jan 03; Vol. 432 (1), pp. 104-122. Date of Electronic Publication: 2019 Jun 22. |
| Publication Type: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
| Language: | English |
| Journal Info: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 2985088R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1089-8638 (Electronic) Linking ISSN: 00222836 NLM ISO Abbreviation: J Mol Biol Subsets: MEDLINE |
| Imprint Name(s): | Publication: Amsterdam : Elsevier; Original Publication: 1959- : London : Academic Press |
| MeSH Terms: | Autophagy*; Autophagosomes/*metabolism ; Autophagy-Related Proteins/*metabolism ; Saccharomyces cerevisiae/*metabolism ; Saccharomyces cerevisiae Proteins/*metabolism ; Vesicular Transport Proteins/*metabolism; Saccharomyces cerevisiae/cytology ; Animals ; Humans ; Macroautophagy ; Protein Interaction Maps |
| Abstract: | Macroautophagy (referred to hereafter as autophagy) is an intracellular degradation pathway in which the formation of a double-membrane vesicle called the autophagosome is a key event in the transport of multiple cytoplasmic cargo (e.g., proteins, protein aggregates, lipid droplets or organelles) to the vacuole (lysosome in mammals) for degradation and recycling. During this process, autophagosomes are formed de novo by membrane fusion events leading to phagophore formation initiated at the phagophore assembly site. In yeast, Atg11 and Atg17 function as protein scaffolds, essential for selective and non-selective types of autophagy, respectively. While Atg17 functions in non-selective autophagy are well-defined in the literature, less attention is concentrated on recent findings regarding the roles of Atg11 in selective autophagy. Here, we summarize current knowledge about the Atg11 scaffold protein and review recent findings in the context of its role in selective autophagy initiation and autophagosome formation.; (Copyright © 2019 Elsevier Ltd. All rights reserved.) |
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| Grant Information: | R01 DK041737 United States DK NIDDK NIH HHS; R03 AI142388 United States AI NIAID NIH HHS |
| Contributed Indexing: | Keywords: Atg11; Atg17; autophagosome; membrane tethering; scaffold protein |
| Substance Nomenclature: | 0 (Atg11 protein, S cerevisiae); 0 (Atg17 protein, S cerevisiae); 0 (Autophagy-Related Proteins); 0 (Saccharomyces cerevisiae Proteins); 0 (Vesicular Transport Proteins) |
| Entry Date(s): | Date Created: 20190626 Date Completed: 20200624 Latest Revision: 20210103 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC6925662 |
| DOI: | 10.1016/j.jmb.2019.06.017 |
| PMID: | 31238043 |
| Database: | MEDLINE |
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review