The Prevalence and Causes of Non-adherence to Immunosuppressive Medications in Patients with Lupus Nephritis Flares.
| Title: | The Prevalence and Causes of Non-adherence to Immunosuppressive Medications in Patients with Lupus Nephritis Flares. |
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| Authors: | Ali AY; Department of Internal Medicine, Kasr Alainy Medical School, Cairo University Hospitals, Cairo, Egypt.; Abdelaziz TS; Department of Internal Medicine, Kasr Alainy Medical School, Cairo University Hospitals, Cairo, Egypt.; Behiry ME; Department of Internal Medicine, Kasr Alainy Medical School, Cairo University Hospitals, Cairo, Egypt. |
| Source: | Current rheumatology reviews [Curr Rheumatol Rev] 2020; Vol. 16 (3), pp. 245-248. |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: Bentham Science Publishers Country of Publication: United Arab Emirates NLM ID: 101261938 Publication Model: Print Cited Medium: Internet ISSN: 1875-6360 (Electronic) Linking ISSN: 15733971 NLM ISO Abbreviation: Curr Rheumatol Rev Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Saif Zone, Sharjah, U.A.E. ; San Francisco, CA : Bentham Science Publishers, 2005- |
| MeSH Terms: | Drug Monitoring*; Glucocorticoids/*therapeutic use ; Immunosuppressive Agents/*therapeutic use ; Lupus Nephritis/*drug therapy; Azathioprine/therapeutic use ; Lupus Nephritis/physiopathology ; Mycophenolic Acid/therapeutic use ; Adult ; Disease Progression ; Drug Costs ; Drug-Related Side Effects and Adverse Reactions ; Female ; Health Expenditures ; Humans ; Male ; Risk Factors ; Symptom Flare Up ; Time Factors ; Young Adult |
| Abstract: | Background: Lupus nephritis is one of the major manifestations of SLE. Poor adherence to medications is an important cause of not achieving treatment targets.; Methods: We assessed patients' adherence to immune-suppressive medications in patients with Lupus nephritis using the Morisky, Green, and Levine (MGL) Adherence Scale. The aim was to study the effect of non-adherence on the occurrence of renal flares.; Results: We recruited 104 patients with lupus nephritis. Sixty-six patients had flares of LN. There was a high prevalence of non-adherence to medications (n=68). Patients who were non-adherent to treatment had more renal flares (p= 0.02). Duration of lupus since diagnosis was significantly higher in patients who had renal flares. Using regression analysis, non-adherence to medications was associated with 3.7 higher risk of developing a single renal flare and 4.9 higher risk of developing more than one renal flare. Causes of non-adherence were medications side effects in 43% of patients, financial issues in 31% or forgetfulness in 26%.; Conclusion: Non-adherence to immunosuppressive medications has a high prevalence in patients with lupus nephritis and is correlated with the number of renal flares.; (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.) |
| Contributed Indexing: | Keywords: Lupus nephritis; adherence; immunosuppression; medication; renal flares; systemic lupus erythromatosus |
| Substance Nomenclature: | 0 (Glucocorticoids); 0 (Immunosuppressive Agents); HU9DX48N0T (Mycophenolic Acid); MRK240IY2L (Azathioprine) |
| Entry Date(s): | Date Created: 20190627 Date Completed: 20210804 Latest Revision: 20260127 |
| Update Code: | 20260130 |
| DOI: | 10.2174/1573397115666190626111847 |
| PMID: | 31241434 |
| Database: | MEDLINE |
Journal Article