Impact of pill burden on adherence to hepatitis C medication.
| Title: | Impact of pill burden on adherence to hepatitis C medication. |
|---|---|
| Authors: | An J; Western University of Health Sciences , Pomona , CA , USA.; Lee JS; Gilead Sciences Inc. , Foster City , CA , USA.; Sharpsten L; Optum , Eden Prairie , MN , USA.; Wilson AK; Optum , Eden Prairie , MN , USA.; Cao F; Optum , Eden Prairie , MN , USA.; Tran JN; Optum , Eden Prairie , MN , USA. |
| Source: | Current medical research and opinion [Curr Med Res Opin] 2019 Nov; Vol. 35 (11), pp. 1937-1944. Date of Electronic Publication: 2019 Sep 25. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Language: | English |
| Journal Info: | Publisher: Informa Healthcare Country of Publication: England NLM ID: 0351014 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1473-4877 (Electronic) Linking ISSN: 03007995 NLM ISO Abbreviation: Curr Med Res Opin Subsets: MEDLINE |
| Imprint Name(s): | Publication: 1995- : Newbury, Berkshire, U.K. : Informa Healthcare; Original Publication: London, M. D. Promotions, ltd. |
| MeSH Terms: | Medication Adherence*; Antiviral Agents/*therapeutic use ; Hepatitis C/*drug therapy; Adult ; Aged ; Aged, 80 and over ; Female ; Humans ; Logistic Models ; Male ; Middle Aged ; Retrospective Studies |
| Abstract: | Objective: To describe pill burden before and after hepatitis C virus (HCV) treatment initiation among patients newly treated for HCV infection, and to evaluate the association between HCV pill burden and gaps in HCV therapy. Methods: This was a retrospective administrative claims study of patients treated with direct-acting antivirals (DAAs) for HCV from 1 November 2013 to 31 July 2016. HCV pill burden was defined as the pill count per day for the index HCV regimen. Mean overall pill burden (HCV medications plus non-HCV medications) was calculated in the 90 days before and after DAA initiation. Gaps in the index HCV regimen were assessed in the 6 months after DAA initiation. Multivariable logistic regression was used to compare the odds of a gap in HCV therapy across HCV pill burden categories (1 pill/day, 2 pills/day, and ≥3 pills/day). Results: Among 9815 patients who met the study criteria, mean overall pill burdens before and after DAA treatment initiation were 5.4 and 7.7, respectively (p |
| Contributed Indexing: | Keywords: Antiviral agents; hepatitis C, chronic; medication adherence; retrospective studies |
| Substance Nomenclature: | 0 (Antiviral Agents) |
| Entry Date(s): | Date Created: 20190713 Date Completed: 20200702 Latest Revision: 20200702 |
| Update Code: | 20260130 |
| DOI: | 10.1080/03007995.2019.1643160 |
| PMID: | 31298592 |
| Database: | MEDLINE |
Journal Article; Research Support, Non-U.S. Gov't