Robust Microfluidic Technology and New Lipid Composition for Fabrication of Curcumin-Loaded Liposomes: Effect on the Anticancer Activity and Safety of Cisplatin.
| Title: | Robust Microfluidic Technology and New Lipid Composition for Fabrication of Curcumin-Loaded Liposomes: Effect on the Anticancer Activity and Safety of Cisplatin. |
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| Authors: | Hamano N; Böttger R; Lee SE; Yang Y; Kulkarni JA; Ip S; Precision NanoSystems Inc , Vancouver , British Columbia V6P 6T7 , Canada.; Cullis PR; Li SD |
| Source: | Molecular pharmaceutics [Mol Pharm] 2019 Sep 03; Vol. 16 (9), pp. 3957-3967. Date of Electronic Publication: 2019 Aug 16. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Language: | English |
| Journal Info: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 101197791 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1543-8392 (Electronic) Linking ISSN: 15438384 NLM ISO Abbreviation: Mol Pharm Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Washington, DC : American Chemical Society, c2004- |
| MeSH Terms: | Antineoplastic Agents/*therapeutic use ; Cisplatin/*therapeutic use ; Curcumin/*chemistry ; Dimyristoylphosphatidylcholine/*chemistry ; Drug Delivery Systems/*methods ; Liposomes/*therapeutic use ; Neoplasms/*drug therapy; Antineoplastic Agents/administration & dosage ; Cisplatin/administration & dosage ; Curcumin/administration & dosage ; Curcumin/pharmacokinetics ; Dimyristoylphosphatidylcholine/administration & dosage ; Drug Compounding/methods ; Liposomes/administration & dosage ; Liposomes/chemistry ; Nanoparticles/chemistry ; Nanotechnology/methods ; Animals ; Cell Line, Tumor ; Disease Models, Animal ; Drug Liberation ; Drug Therapy, Combination ; Female ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Solubility ; Tissue Distribution |
| Abstract: | Curcumin exhibits potent anticancer activity via various mechanisms, but its in vivo efficacy has been hampered by poor solubility. Nanotechnology has been employed to deliver curcumin, but most of the reported systems suffered from low drug loading capacity and poor stability. Here, we report the development and optimization of a liposomal formulation for curcumin (Lipo-Cur) using an automated microfluidic technology. Lipo-Cur exhibited a mean diameter of 120 nm with a low polydispersity index ( |
| Grant Information: | Canada CIHR |
| Contributed Indexing: | Keywords: cisplatin; curcumin; enhanced efficacy and reduced toxicity; lipid nanoparticles; microfluidics |
| Substance Nomenclature: | 0 (Antineoplastic Agents); 0 (Liposomes); IT942ZTH98 (Curcumin); Q20Q21Q62J (Cisplatin); U86ZGC74V5 (Dimyristoylphosphatidylcholine) |
| Entry Date(s): | Date Created: 20190806 Date Completed: 20200608 Latest Revision: 20200608 |
| Update Code: | 20260130 |
| DOI: | 10.1021/acs.molpharmaceut.9b00583 |
| PMID: | 31381352 |
| Database: | MEDLINE |
Journal Article; Research Support, Non-U.S. Gov't