Possible Binding of Piperine in Mycobacterium tuberculosis RNA Polymerase and Rifampin Synergism.
| Title: | Possible Binding of Piperine in Mycobacterium tuberculosis RNA Polymerase and Rifampin Synergism. |
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| Authors: | Murase LS; Department of Clinical Analyses and Biomedicine, State University of Maringá, Maringá, Paraná, Brazil le.murase@gmail.com.; Perez de Souza JV; Department of Clinical Analyses and Biomedicine, State University of Maringá, Maringá, Paraná, Brazil.; Meneguello JE; Department of Clinical Analyses and Biomedicine, State University of Maringá, Maringá, Paraná, Brazil.; Seixas FAV; Department of Technology, State University of Maringa, Umuarama, Paraná, Brazil.; Hegeto LA; Department of Clinical Analyses and Biomedicine, State University of Maringá, Maringá, Paraná, Brazil.; Scodro RBL; Department of Clinical Analyses and Biomedicine, State University of Maringá, Maringá, Paraná, Brazil.; Siqueira VLD; Department of Clinical Analyses and Biomedicine, State University of Maringá, Maringá, Paraná, Brazil.; Caleffi Ferracioli KR; Department of Clinical Analyses and Biomedicine, State University of Maringá, Maringá, Paraná, Brazil.; Cardoso RF; Department of Clinical Analyses and Biomedicine, State University of Maringá, Maringá, Paraná, Brazil. |
| Source: | Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2019 Oct 22; Vol. 63 (11). Date of Electronic Publication: 2019 Oct 22 (Print Publication: 2019). |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Language: | English |
| Journal Info: | Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 0315061 Publication Model: Electronic-Print Cited Medium: Internet ISSN: 1098-6596 (Electronic) Linking ISSN: 00664804 NLM ISO Abbreviation: Antimicrob Agents Chemother Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Washington, American Society for Microbiology |
| MeSH Terms: | Alkaloids/*pharmacology ; Antineoplastic Agents/*pharmacology ; Benzodioxoles/*pharmacology ; DNA-Directed RNA Polymerases/*metabolism ; Mycobacterium tuberculosis/*drug effects ; Piperidines/*pharmacology ; Polyunsaturated Alkamides/*pharmacology ; Rifampin/*pharmacology; Alkaloids/administration & dosage ; Alkaloids/metabolism ; Antineoplastic Agents/administration & dosage ; Antineoplastic Agents/metabolism ; Benzodioxoles/administration & dosage ; Benzodioxoles/metabolism ; Mycobacterium tuberculosis/enzymology ; Mycobacterium tuberculosis/metabolism ; Piperidines/administration & dosage ; Piperidines/metabolism ; Polyunsaturated Alkamides/administration & dosage ; Polyunsaturated Alkamides/metabolism ; Rifampin/administration & dosage ; Rifampin/metabolism ; Binding Sites ; Drug Synergism ; Drug Therapy, Combination ; Molecular Docking Simulation ; Reverse Transcriptase Polymerase Chain Reaction |
| Abstract: | The activity of rifampin (RIF) and piperine was evaluated at the relative transcript levels of 12 efflux pumps (EPs), and an additional mechanism was proposed to be behind the synergic interactions of piperine plus RIF in Mycobacterium tuberculosis AutoDock v4.2.3 and Molegro v6 programs were used to evaluate PIP binding in M. tuberculosis RNA polymerase (RNAP). A hypothesis has been raised that piperine interferes in M. tuberculosis growth through RNAP inhibition, differently from what was previously endorsed for EP inhibition only.; (Copyright © 2019 American Society for Microbiology.) |
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| Contributed Indexing: | Keywords: RNA polymerase; docking; efflux pumps; piperine; rifampin; tuberculosis |
| Substance Nomenclature: | 0 (Alkaloids); 0 (Antineoplastic Agents); 0 (Benzodioxoles); 0 (Piperidines); 0 (Polyunsaturated Alkamides); EC 2.7.7.6 (DNA-Directed RNA Polymerases); U71XL721QK (piperine); VJT6J7R4TR (Rifampin) |
| Entry Date(s): | Date Created: 20190905 Date Completed: 20200819 Latest Revision: 20200819 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC6811433 |
| DOI: | 10.1128/AAC.02520-18 |
| PMID: | 31481438 |
| Database: | MEDLINE |
Journal Article; Research Support, Non-U.S. Gov't