Prevalence of the UGT1A1*28 promoter polymorphism and breast cancer risk among African American women in Memphis, TN.
| Title: | Prevalence of the UGT1A1*28 promoter polymorphism and breast cancer risk among African American women in Memphis, TN. |
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| Authors: | Smith A; Department of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, Memphis, TN 38163, USA.; Cropp CD; Integrated Cancer Genomics Division, Translational Genomics Research Institute (TGen), Phoenix, AZ, 85004, USA.; Department of Pharmaceutical, Social and Administrative Sciences, McWhorter School of Pharmacy, Samford University, Birmingham, AL, 35229, USA.; Vidal G; Division of Hematology/Oncology, Department of Medicine, University of Tennessee Health Science Center, Memphis, TN 38163.; The University of Tennessee West Cancer Center; Memphis, TN 38163.; Pritchard E; The University of Tennessee West Cancer Center; Memphis, TN 38163.; Cordero J; Department of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, Memphis, TN 38163, USA.; Simpson C; Department of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, Memphis, TN 38163, USA.; Starlard-Davenport A; Department of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, Memphis, TN 38163, USA. |
| Source: | Cancer health disparities [Cancer Health Disparities] 2019 Aug 19; Vol. 3, pp. e1-e12. |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: Company of Scientists Publishing Country of Publication: United States NLM ID: 101728460 Publication Model: Print Cited Medium: Internet ISSN: 2573-9530 (Electronic) Linking ISSN: 25739530 NLM ISO Abbreviation: Cancer Health Disparities Subsets: PubMed not MEDLINE |
| Imprint Name(s): | Original Publication: [Birmingham, AL] : Company of Scientists Publishing |
| Abstract: | Inherited variations in UDP-glucuronosyltransferase 1A1 (UGT1A1) are associated with an increased breast cancer risk in women of African ancestry. The UGT1A1*28 promoter polymorphism is characterized by the presence of 7 TA repeats in the TATA box sequence and results in reduced UGT1A1 gene expression and enzymatic activity. In this study, we investigated associations between the UGT1A1*28 polymorphism and breast cancer risk among African American (AA) women in Memphis, Tennessee, a city with increased breast cancer mortality rates among AA women. Saliva was collected from 352 AA women, including breast cancer cases (n=82) and controls (n=270) between June 2016 to June 2017. DNA was isolated and sequenced for the UGT1A1*28 polymorphism. The odds ratio for cases with the low UGT1A1 activity alleles (TA)7/8 repeat genotypes versus 5/5, 5/6, and 6/6 genotypes was 1.46 [95% CI, 0.65-3.31; P = 0.36] in premenopausal women and 1.10 (95% CI, 0.52-2.38; P = 0.79) in postmenopausal women. Further analysis of TCGA RNA-seq data showed that UGT1A1 mRNA was significantly lower among estrogen receptor (ER)-negative breast cancers from AA as compared to non-Hispanic white women with ER-negative breast cancer. Larger epidemiological studies are needed to determine the functional consequence of the UGT1A1*28 polymorphism on breast cancer risk in AA women. |
| Competing Interests: | Conflict of interest The authors declare that no competing or conflict of interests exists. The funders had no role in study design, writing of the manuscript, or decision to publish. |
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| Grant Information: | L60 MD008232 United States MD NIMHD NIH HHS |
| Contributed Indexing: | Keywords: African American; Memphis; TN; UGT1A1; UGT1A1*28; breast cancer disparities |
| Entry Date(s): | Date Created: 20190906 Latest Revision: 20201001 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC6724729 |
| DOI: | 10.9777/chd.2019.1015 |
| PMID: | 31485577 |
| Database: | MEDLINE |
Journal Article