Patient-reported Outcomes During Treatment in Patients with Moderate-to-severe Psoriasis: A Danish Nationwide Study.
| Title: | Patient-reported Outcomes During Treatment in Patients with Moderate-to-severe Psoriasis: A Danish Nationwide Study. |
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| Authors: | Loft ND; Department of Dermatology and Allergy, Herlev and Gentofte Hospital, University of Copenhagen, DK-2900 Hellerup, Denmark. nikolai.dyrberg.loft@regionh.dk.; Egeberg A; Rasmussen MK; Bryld LE; Gniadecki R; Dam TN; Iversen L; Skov L |
| Source: | Acta dermato-venereologica [Acta Derm Venereol] 2019 Dec 01; Vol. 99 (13), pp. 1224-1230. |
| Publication Type: | Comparative Study; Journal Article |
| Language: | English |
| Journal Info: | Publisher: MJS Publishing Country of Publication: Sweden NLM ID: 0370310 Publication Model: Print Cited Medium: Internet ISSN: 1651-2057 (Electronic) Linking ISSN: 00015555 NLM ISO Abbreviation: Acta Derm Venereol Subsets: MEDLINE |
| Imprint Name(s): | Publication: 2024- : Uppsala, Sweden : MJS Publishing; Original Publication: Stockholm : Acta dermato-venereologica |
| MeSH Terms: | Biological Products*/therapeutic use ; Psoriasis*/diagnosis ; Psoriasis*/drug therapy ; Psoriasis*/epidemiology ; Psoriasis*/psychology ; Patient Reported Outcome Measures* ; Quality of Life* ; Registries*; Arthritis, Psoriatic/diagnosis ; Arthritis, Psoriatic/drug therapy ; Arthritis, Psoriatic/epidemiology ; Arthritis, Psoriatic/psychology ; Thalidomide/analogs & derivatives ; Thalidomide/therapeutic use ; Thalidomide/analogs & derivatives ; Adult ; Humans ; Male ; Middle Aged ; Age Factors ; Denmark ; Dose-Response Relationship, Drug ; Drug Administration Schedule ; Risk Assessment ; Severity of Illness Index ; Sex Factors ; Statistics, Nonparametric ; Treatment Outcome ; Female |
| Abstract: | The initiation and evaluation of treatment with biologics for psoriasis is based on the Psoriasis Area Severity Index (PASI) and/or Dermatological Life Quality Index (DLQI). However, these indices do not always correlate well, and changes in the DLQI do not always follow changes in the PASI. Based on data from the Danish national registry (DERMBIO), this study investigated the correlation between changes in PASI and DLQI in a cohort of patients with moderate-to-severe psoriasis treated with biologics or apremilast using Spearman's rank correlation analyses. The correlation analysis of 1,677 patients, of whom 276 had available data after 5 years, showed weak-to-moderate correlation between PASI and DLQI during a 5-year period and between changes in PASI and DLQI: 0.58 (p |
| Contributed Indexing: | Keywords: Dermatology Life Quality Index; Psoriasis Area and Severity Index; biologics; patient-reported outcomes; psoriasis |
| Substance Nomenclature: | UP7QBP99PN (apremilast); 0 (Biological Products); 4Z8R6ORS6L (Thalidomide) |
| Entry Date(s): | Date Created: 20191004 Date Completed: 20200520 Latest Revision: 20260515 |
| Update Code: | 20260515 |
| DOI: | 10.2340/00015555-3331 |
| PMID: | 31580465 |
| Database: | MEDLINE |
Comparative Study; Journal Article