Risk factors for locally advanced cancer associated with ulcerative colitis: Results of a retrospective multicentric study in the era of biologics.
| Title: | Risk factors for locally advanced cancer associated with ulcerative colitis: Results of a retrospective multicentric study in the era of biologics. |
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| Authors: | Rottoli M; Surgery of the Alimentary Tract, Sant'Orsola Hospital, Department of Medical and Surgical Sciences, Alma Mater Studiorum University of Bologna, Bologna, Italy. Electronic address: matteo.rottoli2@unibo.it.; Tanzanu M; Surgery of the Alimentary Tract, Sant'Orsola Hospital, Department of Medical and Surgical Sciences, Alma Mater Studiorum University of Bologna, Bologna, Italy.; Di Candido F; Colon and Rectal Surgery Division, Humanitas Clinical and Research Center, Department of Biomedical Science, Humanitas University, Milan, Italy.; Colombo F; Department of Surgery, Luigi Sacco University Hospital, Milan, Italy.; Frontali A; Beaujon Hospital, Department of Colorectal Surgery and University Paris VII, France.; Chandrasinghe PC; St Mark's Hospital, London, United Kingdom.; Pellino G; Colorectal Unit, Hospital Universitario y Politecnico La Fe, University of Valencia, Valencia, Spain.; Frasson M; Colorectal Unit, Hospital Universitario y Politecnico La Fe, University of Valencia, Valencia, Spain.; Warusavitarne J; St Mark's Hospital, London, United Kingdom.; Panis Y; Beaujon Hospital, Department of Colorectal Surgery and University Paris VII, France.; Sampietro GM; Department of Surgery, Luigi Sacco University Hospital, Milan, Italy.; Spinelli A; Colon and Rectal Surgery Division, Humanitas Clinical and Research Center, Department of Biomedical Science, Humanitas University, Milan, Italy.; Poggioli G; Surgery of the Alimentary Tract, Sant'Orsola Hospital, Department of Medical and Surgical Sciences, Alma Mater Studiorum University of Bologna, Bologna, Italy. |
| Source: | Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver [Dig Liver Dis] 2020 Jan; Vol. 52 (1), pp. 33-37. Date of Electronic Publication: 2019 Sep 30. |
| Publication Type: | Journal Article; Multicenter Study |
| Language: | English |
| Journal Info: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 100958385 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-3562 (Electronic) Linking ISSN: 15908658 NLM ISO Abbreviation: Dig Liver Dis Subsets: MEDLINE |
| Imprint Name(s): | Publication: 2003- : Amsterdam : Elsevier; Original Publication: Roma, Italy : Editrice gastroenterologica italiana, c2000- |
| MeSH Terms: | Colitis, Ulcerative/*complications ; Colorectal Neoplasms/*etiology ; Lymph Nodes/*pathology; Colectomy/adverse effects ; Colitis, Ulcerative/surgery ; Colonoscopy/adverse effects ; Colorectal Neoplasms/epidemiology ; Adolescent ; Adult ; Aged ; Child ; Disease Progression ; Female ; Humans ; Italy ; Logistic Models ; Male ; Middle Aged ; Multivariate Analysis ; Retrospective Studies ; Risk Factors ; Time Factors ; Young Adult |
| Abstract: | Background: Patients affected by ulcerative colitis (UC) are more likely to develop colorectal cancer, and are often diagnosed with lymph node involvement (N+) at surgery.; Aim: To identify the risk factors for N+ cancer in UC patients.; Methods: Patients undergoing surgery from 2001 to 2018 in six European tertiary centres were included. N+ patients were compared to the control group (N-) for clinical variables. The evaluation of risk factors for N+ was assessed using univariate and multivariable logistic regression analyses.; Results: A total of 130 patients were included. Median duration of disease was 21 years (1-52). Forty patients (30.8%) were N+ at surgery. Eighteen (13.8%) developed cancer within 10 years from the onset of UC. Younger age at surgery (Odds ratio -OR- 0.96, p = 0.042), left colon location (OR 2.44, p = 0.045) and the presence of stricture (OR 5.07, p = 0.002) were associated with N+.; Conclusion: Location in the left colon, presence of strictures and younger age strongly correlated with a higher risk of N+ cancer, which could develop before the starting point of surveillance. Duration, extension and severity of disease were not associated with N+. These results should be considered in the evaluation of risk of advanced cancer in UC patients.; (Copyright © 2019 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.) |
| Contributed Indexing: | Keywords: Cancer; Lymph nodes; Ulcerative colitis |
| Entry Date(s): | Date Created: 20191005 Date Completed: 20201106 Latest Revision: 20201106 |
| Update Code: | 20260130 |
| DOI: | 10.1016/j.dld.2019.08.024 |
| PMID: | 31582324 |
| Database: | MEDLINE |
Journal Article; Multicenter Study