Head to Head Comparison of Suppression of Tumorogenicity 2 and Copeptin Significance for Prognosis of Patients After Acute Heart Failure Decompensation.
| Title: | Head to Head Comparison of Suppression of Tumorogenicity 2 and Copeptin Significance for Prognosis of Patients After Acute Heart Failure Decompensation. |
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| Authors: | Skvortsov AA; «Институт клинической кардиологии им. А. Л. Мясникова» ФГБУ «Российский кардиологический научно-производственный комплекс» Минздрава РФ.; Protasov VN; «Институт клинической кардиологии им. А. Л. Мясникова» ФГБУ «Российский кардиологический научно-производственный комплекс» Минздрава РФ.; Narusov OY; «Институт клинической кардиологии им. А. Л. Мясникова» ФГБУ «Российский кардиологический научно-производственный комплекс» Минздрава РФ.; Koshkina DE; ФГБУ «Государственный научно-исследовательский центр профилактической медицины» Минздрава РФ.; Osmolovskaya YF; «Институт клинической кардиологии им. А. Л. Мясникова» ФГБУ «Российский кардиологический научно-производственный комплекс» Минздрава РФ.; Kuznetzova TV; «Институт клинической кардиологии им. А. Л. Мясникова» ФГБУ «Российский кардиологический научно-производственный комплекс» Минздрава РФ.; Masenko VP; «Институт клинической кардиологии им. А. Л. Мясникова» ФГБУ «Российский кардиологический научно-производственный комплекс» Минздрава РФ.; Tereschenko SN; «Институт клинической кардиологии им. А. Л. Мясникова» ФГБУ «Российский кардиологический научно-производственный комплекс» Минздрава РФ. |
| Source: | Kardiologiia [Kardiologiia] 2018 Nov 17; Vol. 57 (9), pp. 20-33. Date of Electronic Publication: 2018 Nov 17. |
| Publication Type: | Comparative Study; Journal Article |
| Language: | English |
| Journal Info: | Publisher: OOO Obshchestvo spet︠s︡ialistov po serdechnoĭ nedostatochnosti Country of Publication: Russia (Federation) NLM ID: 0376351 Publication Model: Electronic Cited Medium: Print ISSN: 0022-9040 (Print) Linking ISSN: 00229040 NLM ISO Abbreviation: Kardiologiia Subsets: MEDLINE |
| Imprint Name(s): | Publication: : Moskva : OOO Obshchestvo spet︠s︡ialistov po serdechnoĭ nedostatochnosti; Original Publication: Moskva. |
| MeSH Terms: | Heart Failure*; Biomarkers ; Glycopeptides ; Humans ; Natriuretic Peptide, Brain ; Prognosis ; Prospective Studies |
| Abstract: | Purpose: To assess the suppression of tumorogenicity 2 (ST2) and copeptin significance for risk stratification of patient (pts) with acute decompensated heart failure (ADHF) during long-term follow-up compared with traditional risk factors.; Methods: We included in a prospective study 159 pts with ADHF. Blood samples to determine copeptin, sST2, NT-proBNP and hsTnT concentration were collected at admission and at discharge from the hospital. Serial determination of biomarker concentration was performed at 3, 6 and 12 months of follow-up. The combined primary end point of the trial included cardiovascular (CV) death, hospitalization due to HF, episodes of HF deterioration requiring additional intravenous diuretics and CV death with successful resuscitation.; Results: During 1-year follow-up (295.3±113.2 days) 56 pts (35.2%) had 78 (49.1%) cardiovascular events. Biomarker concentrations in low risk pts (without CV events) were significantly lower compared with high risk pts (with CV events). Discharge copeptin and NT-proBNP values were comparable for pts risk stratification: AUC=0.727 (95% CI 0.637-0.816), р. |
| Substance Nomenclature: | 0 (Biomarkers); 0 (Glycopeptides); 0 (copeptins); 114471-18-0 (Natriuretic Peptide, Brain) |
| Entry Date(s): | Date Created: 20191113 Date Completed: 20191115 Latest Revision: 20200523 |
| Update Code: | 20260130 |
| DOI: | 10.18087/cardio.2017.9.10028 |
| PMID: | 31713503 |
| Database: | MEDLINE |
Comparative Study; Journal Article