Late-onset systemic lupus erythematosus: characteristics and outcome in comparison to juvenile- and adult-onset patients-a multicenter retrospective cohort.
| Title: | Late-onset systemic lupus erythematosus: characteristics and outcome in comparison to juvenile- and adult-onset patients-a multicenter retrospective cohort. |
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| Authors: | Medhat BM; Rheumatology and Rehabilitation Department, Faculty of Medicine, Cairo University, Kasr Al Ainy St., Cairo, 11562, Egypt. basmamedhat@kasralainy.edu.eg.; Behiry ME; Internal Medicine Department, Faculty of Medicine, Cairo University, Cairo, Egypt.; Sobhy N; Rheumatology and Rehabilitation Department, Faculty of Medicine, Cairo University, Kasr Al Ainy St., Cairo, 11562, Egypt.; Farag Y; Pediatric Rheumatology Department, Faculty of Medicine, Cairo University, Cairo, Egypt.; Marzouk H; Pediatric Rheumatology Department, Faculty of Medicine, Cairo University, Cairo, Egypt.; Mostafa N; Pediatric Rheumatology Department, Faculty of Medicine, Cairo University, Cairo, Egypt.; Khalifa I; Pediatric Department, Faculty of Medicine, Helwan University, Helwan, Egypt.; Elkhalifa M; Rheumatology Unit, Internal Medicine Department, Faculty of Medicine, Alexandria University, Alexandria, Egypt.; Eissa BM; Rheumatology and Rehabilitation Department, Faculty of Medicine, Cairo University, Kasr Al Ainy St., Cairo, 11562, Egypt.; Hassan EHE; Rheumatology Unit, Internal Medicine Department, Faculty of Medicine, Alexandria University, Alexandria, Egypt. |
| Source: | Clinical rheumatology [Clin Rheumatol] 2020 Feb; Vol. 39 (2), pp. 435-442. Date of Electronic Publication: 2019 Nov 22. |
| Publication Type: | Comparative Study; Journal Article; Multicenter Study |
| Language: | English |
| Journal Info: | Publisher: Springer Country of Publication: Germany NLM ID: 8211469 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1434-9949 (Electronic) Linking ISSN: 07703198 NLM ISO Abbreviation: Clin Rheumatol Subsets: MEDLINE |
| Imprint Name(s): | Publication: : Heidelberg : Springer; Original Publication: Brussels : Acta Medica Belgica, [1982- |
| MeSH Terms: | Lupus Erythematosus, Systemic/*epidemiology; Egypt/epidemiology ; Glucocorticoids/administration & dosage ; Immunosuppressive Agents/administration & dosage ; Lupus Erythematosus, Systemic/drug therapy ; Adolescent ; Adult ; Age of Onset ; Aged ; Child ; Comorbidity ; Female ; Humans ; Male ; Middle Aged ; Retrospective Studies ; Severity of Illness Index ; Young Adult |
| Abstract: | Introduction: The aim of this study was to investigate the characteristics and outcome of systemic lupus erythematosus (SLE) among elderly-onset patients.; Methods: This study included 575 SLE patients managed at Cairo, Alexandria, and Helwan universities from August 2014 to 2018: of whom 49 (8.5%), 420 (73%), and 106 (18.4%) were elderly- (> 50 years), adult- (17-50 years), and juvenile- (≤ 16 years) onset patients, respectively. Cumulative characteristics were recorded. Disease activity at the last visit was investigated through the Systemic Lupus Erythematosus Disease Activity Index-2K (SLEDAI-2K), whereby lupus low disease activity (LLDA) was defined as a SLEDAI-2K score ≤ 4. The disease outcome was assessed through investigating disease damage (Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index (SDI)) and the prevalence of mortality. Quantitative and categorical data were compared using Kruskal-Wallis and Mann-Whitney tests, and chi-square (χ2) test, respectively.; Results: Late-onset SLE (LSLE) patients demonstrated the lowest prevalence of constitutional and mucocutaneous manifestations (p |
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| Contributed Indexing: | Keywords: Characteristics; Disease outcome; Elderly onset; Juvenile; Late onset; Systemic lupus erythematosus |
| Substance Nomenclature: | 0 (Glucocorticoids); 0 (Immunosuppressive Agents) |
| Entry Date(s): | Date Created: 20191124 Date Completed: 20201119 Latest Revision: 20220801 |
| Update Code: | 20260130 |
| DOI: | 10.1007/s10067-019-04776-y |
| PMID: | 31758421 |
| Database: | MEDLINE |
Comparative Study; Journal Article; Multicenter Study