Positive Resection Margins Detected by Standardized Study of a Pancreaticoduodenectomy Sample: Is There Any Real Impact on Long-term Survival?
| Title: | Positive Resection Margins Detected by Standardized Study of a Pancreaticoduodenectomy Sample: Is There Any Real Impact on Long-term Survival? |
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| Transliterated Title: | Margen de resección positivo tras la aplicación de un examen estandarizado de la muestra de duodenopancreatectomía cefálica: ¿tiene un impacto real en la supervivencia a largo plazo? |
| Authors: | Di Martino M; Servicio de Cirugía General y del Aparato Digestivo, Hospital Universitario La Princesa, Madrid, España. Electronic address: marcellodima@gmail.com.; Muñoz de Nova JL; Servicio de Cirugía General y del Aparato Digestivo, Hospital Universitario La Princesa, Madrid, España.; Guijarro Rojas M; Servicio de Anatomía Patológica, Hospital Universitario La Princesa, Madrid, España.; Alday Muñoz E; Servicio de Anestesiología y Reanimación, Hospital Universitario La Princesa, Madrid, España.; Martín-Pérez E; Servicio de Cirugía General y del Aparato Digestivo, Hospital Universitario La Princesa, Madrid, España. |
| Source: | Cirugia espanola [Cir Esp (Engl Ed)] 2020 Mar; Vol. 98 (3), pp. 127-135. Date of Electronic Publication: 2019 Nov 26. |
| Publication Type: | Journal Article |
| Language: | English; Spanish; Castilian |
| Journal Info: | Publisher: Elsevier España Country of Publication: Spain NLM ID: 101771152 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2173-5077 (Electronic) Linking ISSN: 21735077 NLM ISO Abbreviation: Cir Esp (Engl Ed) Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Madrid : Elsevier España |
| MeSH Terms: | Carcinoma, Pancreatic Ductal*/diagnosis ; Carcinoma, Pancreatic Ductal*/mortality ; Carcinoma, Pancreatic Ductal*/pathology ; Carcinoma, Pancreatic Ductal*/surgery ; Pancreatic Neoplasms*/diagnosis ; Pancreatic Neoplasms*/mortality ; Pancreatic Neoplasms*/pathology ; Pancreatic Neoplasms*/surgery ; Margins of Excision* ; Pancreaticoduodenectomy*; Aged ; Disease-Free Survival ; Female ; Humans ; Male ; Middle Aged ; Neoplasm Recurrence, Local ; Prognosis ; Retrospective Studies |
| Abstract: | Introduction: The pathological evaluation of pancreaticoduodenectomy (PD) samples and the impact of R1 resections on survival has recently been questioned. This study evaluates the introduction of a standardized pathology study protocol (PSP) and the prognosis of R1 resections after long-term follow-up.; Methods: We reviewed data from a prospectively maintained database regarding 109 periampullary tumors treated by PD from 2005 to 2013. The results of the introduction of a PSP were analysed, and the recurrence rate (RR), disease-free survival (DFS) and overall survival (OS) of the R1 resections were evaluated for each positive margin.; Results: The PD specimens of periampullary tumors analyzed by PSP showed a higher rate of isolated lymph nodes (17 vs. 8; P=.003), N+ (60% vs. 31%; P |
| Contributed Indexing: | Keywords: Duodenopancreatectomía cefálica; Margen de resección; Neoplasia pancreática; Pancreatic cancer; Pancreaticoduodenectomy; Resection margin |
| Entry Date(s): | Date Created: 20191201 Date Completed: 20201214 Latest Revision: 20210521 |
| Update Code: | 20260130 |
| DOI: | 10.1016/j.ciresp.2019.09.006 |
| PMID: | 31784034 |
| Database: | MEDLINE |
Journal Article