Negative Association of Interleukin-33 Plasma Levels and Schistosomiasis Infection in a Site of Polyparasitism in Rural Cameroon.
| Title: | Negative Association of Interleukin-33 Plasma Levels and Schistosomiasis Infection in a Site of Polyparasitism in Rural Cameroon. |
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| Authors: | Kamdem SD; Division of Immunology, Health Science Faculty, University of Cape Town, Cape Town, South Africa.; Cape Town Component, International Centre for Genetic Engineering and Biotechnology, Cape Town, South Africa.; Immunology of Infectious Diseases Unit, South African Medical Research Centre, Cape Town, South Africa.; Konhawa F; School of Health Sciences, Catholic University of Central Africa, Yaoundé, Cameroon.; Kuemkon EM; School of Health Sciences, Catholic University of Central Africa, Yaoundé, Cameroon.; Meyo Kamguia L; School of Health Sciences, Catholic University of Central Africa, Yaoundé, Cameroon.; Tchanana GK; School of Health Sciences, Catholic University of Central Africa, Yaoundé, Cameroon.; CIAB EXACT Medical Laboratory, Yaoundé, Cameroon.; Nche F; Faculty of Medicine and Biomedical Sciences, University of Yaoundé 1, Yaoundé, Cameroon.; Oumarou A; Ministry of Public Health, Yaoundé, Cameroon.; Hamza M; Ministry of Public Health, Yaoundé, Cameroon.; Ouratou Y; Biotechnology Centre, University of Yaoundé 1, Yaoundé, Cameroon.; Tcheutchoua MN; Biotechnology Centre, University of Yaoundé 1, Yaoundé, Cameroon.; Ghislain Essomba R; School of Health Sciences, Catholic University of Central Africa, Yaoundé, Cameroon.; National Public Health Laboratory, Ministry of Public Health, Yaoundé, Cameroon.; Ngogang MP; LABOREB, Yaoundé, Cameroon.; Kengne M; School of Health Sciences, Catholic University of Central Africa, Yaoundé, Cameroon.; Netongo PM; Biotechnology Centre, University of Yaoundé 1, Yaoundé, Cameroon.; Department of Biochemistry, University of Yaoundé 1, Yaoundé, Cameroon.; Ondigui BE; National Public Health Laboratory, Ministry of Public Health, Yaoundé, Cameroon.; Okomo Assoumou MC; National Public Health Laboratory, Ministry of Public Health, Yaoundé, Cameroon.; Brombacher F; Division of Immunology, Health Science Faculty, University of Cape Town, Cape Town, South Africa.; Cape Town Component, International Centre for Genetic Engineering and Biotechnology, Cape Town, South Africa.; Immunology of Infectious Diseases Unit, South African Medical Research Centre, Cape Town, South Africa.; Wellcome Centre for Infectious Diseases Research in Africa, Institute of Infectious Diseases and Molecular Medicine (IDM), University of Cape Town, Cape Town, South Africa.; Nono JK; Division of Immunology, Health Science Faculty, University of Cape Town, Cape Town, South Africa.; Cape Town Component, International Centre for Genetic Engineering and Biotechnology, Cape Town, South Africa.; Immunology of Infectious Diseases Unit, South African Medical Research Centre, Cape Town, South Africa.; The Medical Research Centre, Institute of Medical Research and Medicinal Plant Studies, Ministry of Scientific Research and Innovation, Yaoundé, Cameroon. |
| Source: | Frontiers in immunology [Front Immunol] 2019 Dec 03; Vol. 10, pp. 2827. Date of Electronic Publication: 2019 Dec 03 (Print Publication: 2019). |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Language: | English |
| Journal Info: | Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: [Lausanne : Frontiers Research Foundation] |
| MeSH Terms: | Interleukin-33/*blood ; Schistosomiasis mansoni/*blood; Cameroon/epidemiology ; Coinfection/blood ; Coinfection/epidemiology ; Hepatitis/blood ; Hepatitis/epidemiology ; Liver Cirrhosis/blood ; Liver Cirrhosis/epidemiology ; Malaria/blood ; Malaria/epidemiology ; Schistosomiasis mansoni/epidemiology ; Adolescent ; Animals ; Child ; Female ; Humans ; Male ; Prevalence ; Rural Population ; Schistosoma mansoni |
| Abstract: | Background: This study aimed to investigate the association of plasma levels of IL-33, a mucosal alarmin known to elicit type-2 immunity, with infection and liver fibrosis profiles of school children from an endemic area for Schistosoma mansoni, malaria and hepatitis (B & C) in rural Cameroon. Methods: A cross-sectional study enrolling schoolchildren from 5 public schools was conducted. Single schistosomiasis, malaria and hepatitis infections or co-infections were assessed by kato katz, microscopy, and rapid diagnostic tests, respectively. Hepatic fibrosis was assessed by ultrasound according to WHO Niamey guidelines and plasma levels of Interleukin 33 were determined by ELISA. All statistics were performed using R studio software. Principal findings: We found a prevalence of 13.5% (37/275), 18.2% (50/275), and 8% (22/275), respectively for schistosomiasis, malaria and hepatitis (B or C) single infections. Only 7.6% (21/275) of co-infections were reported. Although Plasma IL-33 showed a minimal negative risk for schistosomiasis infection (AOR 0.99; 95% CI 0.97-1.01), S. mansoni infected participants had lower levels of plasma IL-33 (p = 0.003) which decreased significantly as eggs burdens increased (p = 0.01) with a negative Pearson coefficient of r = -0.22. Hepatic fibrosis occurred in 47.3% (130/275) of our study population independently from plasma levels of IL-33 (AOR 1.00; 95% CI 0.99-1.01). Conclusion/Significance: Our data failed to show an association between plasma IL-33 levels and liver disease but convincingly report on a negative association between plasma IL-33 levels and schistosomiasis infection and egg burden in school children from a polyparasitic schistosomiasis endemic area.; (Copyright © 2019 Kamdem, Konhawa, Kuemkon, Meyo Kamguia, Tchanana, Nche, Oumarou, Hamza, Ouratou, Tcheutchoua, Ghislain Essomba, Ngogang, Kengne, Netongo, Ondigui, Okomo Assoumou, Brombacher and Nono.) |
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| Grant Information: | United Kingdom MRC_ Medical Research Council |
| Contributed Indexing: | Keywords: cameroon; hepatic fibrosis; hepatitis; interleukin 33; malaria; polyparasitism; schistosomiasis; schoolchildren |
| Substance Nomenclature: | 0 (IL33 protein, human); 0 (Interleukin-33) |
| Entry Date(s): | Date Created: 20191219 Date Completed: 20201119 Latest Revision: 20201119 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC6901687 |
| DOI: | 10.3389/fimmu.2019.02827 |
| PMID: | 31849991 |
| Database: | MEDLINE |
Journal Article; Research Support, Non-U.S. Gov't