The PAP/SAL1 retrograde signaling pathway is involved in iron homeostasis.
| Title: | The PAP/SAL1 retrograde signaling pathway is involved in iron homeostasis. |
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| Authors: | Balparda M; Centro de Estudios Fotosintéticos y Bioquímicos (CEFOBI), CONICET-Universidad Nacional de Rosario, Suipacha 531, 2000, Rosario, Argentina.; Armas AM; Centro de Estudios Fotosintéticos y Bioquímicos (CEFOBI), CONICET-Universidad Nacional de Rosario, Suipacha 531, 2000, Rosario, Argentina.; Estavillo GM; CSIRO Agriculture and Food, Black Mountain, Canberra, ACT, 2601, Australia.; Roschzttardtz H; Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, Chile.; Pagani MA; Centro de Estudios Fotosintéticos y Bioquímicos (CEFOBI), CONICET-Universidad Nacional de Rosario, Suipacha 531, 2000, Rosario, Argentina. pagani@cefobi-conicet.gov.ar.; Gomez-Casati DF; Centro de Estudios Fotosintéticos y Bioquímicos (CEFOBI), CONICET-Universidad Nacional de Rosario, Suipacha 531, 2000, Rosario, Argentina. gomezcasati@cefobi-conicet.gov.ar. |
| Source: | Plant molecular biology [Plant Mol Biol] 2020 Feb; Vol. 102 (3), pp. 323-337. Date of Electronic Publication: 2020 Jan 03. |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: Kluwer Academic Country of Publication: Netherlands NLM ID: 9106343 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-5028 (Electronic) Linking ISSN: 01674412 NLM ISO Abbreviation: Plant Mol Biol Subsets: MEDLINE |
| Imprint Name(s): | Publication: Dordrecht : Kluwer Academic; Original Publication: The Hague ; Boston : Martinus Nijhoff/Dr. W. Junk, 1981- |
| MeSH Terms: | Signal Transduction*; Adenosine Diphosphate/*metabolism ; Arabidopsis/*metabolism ; Arabidopsis Proteins/*metabolism ; Iron/*metabolism ; Phosphoric Monoester Hydrolases/*metabolism; Adenosine Diphosphate/genetics ; Arabidopsis/genetics ; Arabidopsis/growth & development ; Arabidopsis Proteins/genetics ; Chloroplasts/metabolism ; Ferritins/genetics ; Ferritins/metabolism ; Genes, Plant/genetics ; Mitochondria/metabolism ; Phosphoric Monoester Hydrolases/genetics ; Plant Leaves/metabolism ; Plant Roots/growth & development ; Plant Roots/metabolism ; Chlorophyll ; Gene Expression Profiling ; Gene Expression Regulation, Plant ; Homeostasis ; Mutation |
| Abstract: | Key Message: There is a link between PAP/SAL retrograde pathway, ethylene signaling and Fe metabolism in Arabidopsis. Nuclear gene expression is regulated by a diversity of retrograde signals that travel from organelles to the nucleus in a lineal or classical model. One such signal molecule is 3'-phosphoadenisine-5'-phosphate (PAP) and it's in vivo levels are regulated by SAL1/FRY1, a phosphatase enzyme located in chloroplast and mitochondria. This metabolite inhibits the action of a group of exorribonucleases which participate in post-transcriptional gene expression regulation. Transcriptome analysis of Arabidopsis thaliana mutant plants in PAP-SAL1 pathway revealed that the ferritin genes AtFER1, AtFER3, and AtFER4 are up-regulated. In this work we studied Fe metabolism in three different mutants of the PAP/SAL1 retrograde pathway. Mutant plants showed increased Fe accumulation in roots, shoots and seeds when grown in Fe-sufficient condition, and a constitutive activation of the Strategy I Fe uptake genes. As a consequence, they grew more vigorously than wild type plants in Fe-deficient medium. However, when mutant plants grown in Fe-deficient conditions were sprayed with Fe in their leaves, they were unable to deactivate root Fe uptake. Ethylene synthesis inhibition revert the constitutive Fe uptake phenotype. We propose that there is a link between PAP/SAL pathway, ethylene signaling and Fe metabolism. |
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| Grant Information: | PICT 2016 350 Fondo para la Investigación Científica y Tecnológica; PICT 2016 264 Fondo para la Investigación Científica y Tecnológica |
| Contributed Indexing: | Keywords: Chloroplast; Iron homeostasis; Mitochondria; PAP/SAL1; Retrograde signals |
| Substance Nomenclature: | 0 (Arabidopsis Proteins); 0 (FER1 protein, Arabidopsis); 0 (Fer3 protein, Arabidopsis); 0 (Fer4 protein, Arabidopsis); 1406-65-1 (Chlorophyll); 61D2G4IYVH (Adenosine Diphosphate); 9007-73-2 (Ferritins); C65F80D52U (adenosine 3'-phosphate-5'-phosphate); E1UOL152H7 (Iron); EC 3.1.3.2 (Phosphoric Monoester Hydrolases); EC 3.1.3.57 (inositol-1,4-bisphosphate 1-phosphatase) |
| Entry Date(s): | Date Created: 20200105 Date Completed: 20200213 Latest Revision: 20220412 |
| Update Code: | 20260130 |
| DOI: | 10.1007/s11103-019-00950-7 |
| PMID: | 31900819 |
| Database: | MEDLINE |
Journal Article