Incidences of Hypothyroidism Associated With Surgical Procedures for Thyroid Disorders: A Nationwide Population-Based Study.
| Title: | Incidences of Hypothyroidism Associated With Surgical Procedures for Thyroid Disorders: A Nationwide Population-Based Study. |
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| Authors: | Tsai SH; Graduate Institute of Injury Prevention and Control, Taipei Medical University, Taipei, Taiwan.; Emergency Department, Shuang-Ho Hospital, Taipei Medical University, Taipei, Taiwan.; Chien SC; Graduate Institute of Biomedical Informatics, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan.; Nguyen PA; International Center for Health Information Technology (ICHIT), Taipei Medical University, Taipei, Taiwan.; Chien PH; Department and Graduate Institute of Business Administration, National Taiwan University, Taipei, Taiwan.; Ma HP; Graduate Institute of Injury Prevention and Control, Taipei Medical University, Taipei, Taiwan.; Emergency Department, Shuang-Ho Hospital, Taipei Medical University, Taipei, Taiwan.; Asdary RN; Master Program in Global Health and Development, PhD Program in Global Health and Health Security, College of Public Health, Taipei Medical University, Taipei, Taiwan.; Wang YC; Graduate Institute of Injury Prevention and Control, Taipei Medical University, Taipei, Taiwan.; Graduate Institute of Biomedical Informatics, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan.; International Center for Health Information Technology (ICHIT), Taipei Medical University, Taipei, Taiwan.; Department of Emergency, Min-Sheng General Hospital, Taoyuan, Taiwan.; Humayun A; Department of Public Health and Community Medicine, Shaikh Khalifa Bin Zayed Al-Nahyan Medical College, Shaikh Zayed Medical Complex, Lahore, Pakistan.; Huang CL; Division of Endocrinology and Metabolism, Department of Internal Medicine, Taipei Medical University Hospital, Taipei, Taiwan.; Iqbal U; International Center for Health Information Technology (ICHIT), Taipei Medical University, Taipei, Taiwan.; Master Program in Global Health and Development, PhD Program in Global Health and Health Security, College of Public Health, Taipei Medical University, Taipei, Taiwan.; Department of Public Health and Community Medicine, Shaikh Khalifa Bin Zayed Al-Nahyan Medical College, Shaikh Zayed Medical Complex, Lahore, Pakistan.; Jian WS; School of Health Care Administration, Taipei Medical University, Taipei, Taiwan. |
| Source: | Frontiers in pharmacology [Front Pharmacol] 2019 Dec 12; Vol. 10, pp. 1378. Date of Electronic Publication: 2019 Dec 12 (Print Publication: 2019). |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: Frontiers Media] Country of Publication: Switzerland NLM ID: 101548923 Publication Model: eCollection Cited Medium: Print ISSN: 1663-9812 (Print) Linking ISSN: 16639812 NLM ISO Abbreviation: Front Pharmacol Subsets: PubMed not MEDLINE |
| Imprint Name(s): | Original Publication: [Lausanne : Frontiers Media] |
| Abstract: | Background and Aim: Limited information available about different types of thyroid surgeries with risk for postoperative hypothyroidism. This study aimed to investigate the risk of developing early and late-onset postoperative hypothyroidism in patients with thyroid disorders. Methods: We used a large cohort data from the Taiwan National Health Insurance Research Data Base (NHIRDB) and identified 9,693 (9, 348) patients from January 1998 to December 2010, admitted for thyroid disorder surgeries. We used the surgical procedures time as the index date. Our observational retrospective cohort study excluded the subjects diagnosed with hypoparathyroidism and hypothyroidism before any surgeries. We analyzed the data using the Cox regression model to calculate the hazard ratio. Result: Postoperative hypothyroidism associated with bilateral-total (HR, 4.27; 95% CI, 3.32-5.50), one-side total and another subtotal (HR, 3.16; 95% CI, 2.59-3.86), bilateral-subtotal (HR, 1.65; 95% CI, 1.37-1.98), and unilateral-total (HR, 1.17; 95% CI, 0.95-1.44) surgical procedures. The time intervals for thyroid disorders were 320 cases developed postoperative hypoparathyroidism in eight weeks, 480 cases the second month, and 1000 cases in the first year after surgery. Conclusion: Findings suggest that thyroidectomy was associated with transient postoperative hypothyroidism in thyroid disorder patients. The bilateral-total surgical procedure was strongly associated with temporary postoperative hypothyroidism.; (Copyright © 2019 Tsai, Chien, Nguyen, Chien, Ma, Asdary, Wang, Humayun, Huang, Iqbal and Jian.) |
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| Contributed Indexing: | Keywords: BigData analytics; hormones; postoperative hypothyroidism; surgeons experience; thyroid disorders; thyroid surgeries; transient hypothyroidism |
| Entry Date(s): | Date Created: 20200111 Latest Revision: 20200930 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC6920095 |
| DOI: | 10.3389/fphar.2019.01378 |
| PMID: | 31920634 |
| Database: | MEDLINE |
Journal Article