Postbiotics for Preventing and Treating Common Infectious Diseases in Children: A Systematic Review.
| Title: | Postbiotics for Preventing and Treating Common Infectious Diseases in Children: A Systematic Review. |
|---|---|
| Authors: | Malagón-Rojas JN; Doctorado en Salud Pública, Facultad de Medicina, Universidad El Bosque, 110121 Bogota, Colombia.; Instituto Nacional de Salud de Colombia, 111321 Bogota, Colombia.; Mantziari A; Functional Foods Forum, Faculty of Medicine, University of Turku, 20520 Turku, Finland.; Salminen S; Functional Foods Forum, Faculty of Medicine, University of Turku, 20520 Turku, Finland.; Szajewska H; Department of Paediatrics at the Medical University of Warsaw, 02091 Warsaw, Poland. |
| Source: | Nutrients [Nutrients] 2020 Jan 31; Vol. 12 (2). Date of Electronic Publication: 2020 Jan 31. |
| Publication Type: | Journal Article; Systematic Review |
| Language: | English |
| Journal Info: | Publisher: MDPI Publishing Country of Publication: Switzerland NLM ID: 101521595 Publication Model: Electronic Cited Medium: Internet ISSN: 2072-6643 (Electronic) Linking ISSN: 20726643 NLM ISO Abbreviation: Nutrients Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Basel, Switzerland : MDPI Publishing |
| MeSH Terms: | Anti-Bacterial Agents/*therapeutic use ; Diarrhea/*prevention & control ; Laryngitis/*prevention & control ; Pharyngitis/*prevention & control ; Probiotics/*therapeutic use; Diarrhea/microbiology ; Diarrhea/therapy ; Fermented Foods/microbiology ; Infant Formula/microbiology ; Laryngitis/microbiology ; Laryngitis/therapy ; Pharyngitis/microbiology ; Pharyngitis/therapy ; Child, Preschool ; Female ; Humans ; Infant ; Male ; Randomized Controlled Trials as Topic |
| Abstract: | Postbiotics have recently been tentatively defined as bioactive compounds produced during a fermentation process (including microbial cells, cell constituents and metabolites) that supports health and/or wellbeing. Postbiotics are currently available in some infant formulas and fermented foods. We systematically reviewed evidence on postbiotics for preventing and treating common infectious diseases among children younger than 5 years. The PubMed, Embase, SpringerLink, and ScienceDirect databases were searched up to March 2019 for randomized controlled trials (RCTs) comparing postbiotics with placebo or no intervention. Seven RCTs involving 1740 children met the inclusion criteria. For therapeutic trials, supplementation with heat-killed Lactobacillus acidophilus LB reduced the duration of diarrhea (4 RCTs, n = 224, mean difference, MD, -20.31 h, 95% CI -27.06 to -13.57). For preventive trials, the pooled results from two RCTs (n = 537) showed that heat-inactivated L. paracasei CBA L74 versus placebo reduced the risk of diarrhea (relative risk, RR, 0.51, 95% CI 0.37-0.71), pharyngitis (RR 0.31, 95% CI 0.12-0.83) and laryngitis (RR 0.44, 95% CI 0.29-0.67). There is limited evidence to recommend the use of specific postbiotics for treating pediatric diarrhea and preventing common infectious diseases among children. Further studies are necessary to determine the effects of different postbiotics. |
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| Grant Information: | 80095712 HEI ICI PECOLO project awarded to the University of Turku Future Research Centre and Functional Foods Forum. |
| Contributed Indexing: | Keywords: 1 postbiotics; 2 probiotics; 3 common infectious diseases; 4 children; 5 public health |
| Substance Nomenclature: | 0 (Anti-Bacterial Agents) |
| Entry Date(s): | Date Created: 20200207 Date Completed: 20201118 Latest Revision: 20240727 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC7071176 |
| DOI: | 10.3390/nu12020389 |
| PMID: | 32024037 |
| Database: | MEDLINE |
Journal Article; Systematic Review