Histopathological Evaluation of Mechanoreceptors in the Metatarsophalangeal Joint Capsule in Hallux Valgus.
| Title: | Histopathological Evaluation of Mechanoreceptors in the Metatarsophalangeal Joint Capsule in Hallux Valgus. |
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| Authors: | Şirin E; Assistant Professor, Marmara University School of Medicine, Department of Orthopaedic Surgery and Traumatology, Istanbul, Turkey. Electronic address: evrimsirin@yahoo.com.; Kandemir C; Assistant Professor, Marmara University School of Medicine, Department of Histology, Istanbul, Turkey.; Yılmaz B; Associate Professor, Fatih Sultan Mehmet Education and Research Hospital, Department of Orthopaedic Surgery and Traumatology, Istanbul, Turkey.; Özdemir G; Associate Professor, Ankara Numune Education and Research Hospital, Department of Orthopedic Surgery and Traumatology, Ankara, Turkey.; Akakın D; Associate Professor, Marmara University School of Medicine, Department of Histology, Istanbul, Turkey.; Muratlı HH; Professor, Marmara University School of Medicine, Department of Orthopaedic Surgery and Traumatology, Istanbul, Turkey. |
| Source: | The Journal of foot and ankle surgery : official publication of the American College of Foot and Ankle Surgeons [J Foot Ankle Surg] 2020 May - Jun; Vol. 59 (3), pp. 518-521. Date of Electronic Publication: 2020 Feb 26. |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: W.B. Saunders Country of Publication: United States NLM ID: 9308427 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1542-2224 (Electronic) Linking ISSN: 10672516 NLM ISO Abbreviation: J Foot Ankle Surg Subsets: MEDLINE |
| Imprint Name(s): | Publication: 2003- : Philadelphia : W.B. Saunders; Original Publication: Baltimore, MD : Williams & Wilkins, c1993- |
| MeSH Terms: | Hallux Valgus/*pathology ; Joint Capsule/*pathology ; Mechanoreceptors/*pathology ; Metatarsophalangeal Joint/*pathology; Adolescent ; Adult ; Aged ; Cadaver ; Case-Control Studies ; Female ; Humans ; Male ; Middle Aged ; Young Adult |
| Abstract: | To date, we could find no study concerning the relationship between mechanoreceptors in the joint capsule of the first metatarsophalangeal joint and hallux valgus deformity. We aimed to investigate the presence of mechanoreceptors in samples obtained from the first metatarsophalangeal joint capsules of patients with hallux valgus deformity to improve our understanding of the clinical and histopathological features of the disease. Samples were taken from the first metatarsophalangeal joint capsules of 13 fresh-frozen cadavers with normal anatomy (controls) and 29 patients undergoing surgery for hallux valgus (cases). For light microscopy, excised specimens were fixed in 10% formaldehyde and processed for routine histopathological investigation. All samples were dehydrated in a series of ethanol, cleared in xylene, and embedded in paraffin. Orientation of collagen fibers was determined on Masson's trichrome-stained sections, and mechanoreceptors were evaluated on S-100-immunostained sections. In the sections stained with Masson's trichrome, the orientation of collagen fibers was regular in the control group. However, coarse and disoriented collagen bundles were observed in the hallux valgus cases (P ≤ .05). S-100 immunostaining was positive in the sections of both the cases and controls. Finally, free nerve endings were more abundant in the samples obtained from the capsules of hallux valgus cases than from the control group (P ≤ .05). An increase in the number of free nerve endings within the capsules of the first metatarsophalangeal joints in feet with hallux valgus deformity might have a role in the development of clinically relevant joint pain and instability.; (Copyright © 2020 the American College of Foot and Ankle Surgeons. Published by Elsevier Inc. All rights reserved.) |
| Contributed Indexing: | Keywords: hallux valgus; joint capsule; mechanoreceptor; pain; proprioception |
| Entry Date(s): | Date Created: 20200302 Date Completed: 20210401 Latest Revision: 20210401 |
| Update Code: | 20260130 |
| DOI: | 10.1053/j.jfas.2019.10.002 |
| PMID: | 32113826 |
| Database: | MEDLINE |
Journal Article