Serum betatrophin levels are significantly increased in obese patients compared to lean patients regardless to the presence of PCOS.
| Title: | Serum betatrophin levels are significantly increased in obese patients compared to lean patients regardless to the presence of PCOS. |
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| Authors: | Keyif B; Department of Obstetrics and Gynecology, Hakkari Yuksekova General Hospital, Hakkari, Turkey.; Goksever Celik H; Department of Obstetrics and Gynecology, Saglik Bilimleri University Istanbul Kanuni Sultan Suleyman Training and Research Hospital, Istanbul, Turkey.; Karamustafaoglu Balci B; Istanbul Faculty of Medicine, Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Istanbul University, Istanbul, Turkey.; Mehves Celebi M; Faculty of Medicine, Department of Obstetrics and Gynecology, Acıbadem Mehmet Ali Aydınlar University, Istanbul, Turkey.; Ozaltin S; Faculty of Medicine, Department of Obstetrics and Gynecology, Acıbadem Mehmet Ali Aydınlar University, Istanbul, Turkey.; Takmaz O; Faculty of Medicine, Department of Obstetrics and Gynecology, Acıbadem Mehmet Ali Aydınlar University, Istanbul, Turkey.; Buyru F; Faculty of Medicine, Department of Obstetrics and Gynecology, Acıbadem Mehmet Ali Aydınlar University, Istanbul, Turkey.; Baştu E; Faculty of Medicine, Department of Obstetrics and Gynecology, Acıbadem Mehmet Ali Aydınlar University, Istanbul, Turkey. |
| Source: | Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology [Gynecol Endocrinol] 2020 Aug; Vol. 36 (8), pp. 678-681. Date of Electronic Publication: 2020 Mar 04. |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: Informa Healthcare Country of Publication: England NLM ID: 8807913 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1473-0766 (Electronic) Linking ISSN: 09513590 NLM ISO Abbreviation: Gynecol Endocrinol Subsets: MEDLINE |
| Imprint Name(s): | Publication: London : Informa Healthcare; Original Publication: [Carnforth, Lancashire ; Park Ridge, N.J.] : Parthenon Pub., [c1987- |
| MeSH Terms: | Angiopoietin-like Proteins/*blood ; Obesity/*blood ; Peptide Hormones/*blood ; Polycystic Ovary Syndrome/*blood ; Thinness/*blood; Insulin Resistance/physiology ; Obesity/complications ; Polycystic Ovary Syndrome/complications ; Thinness/complications ; Adult ; Angiopoietin-Like Protein 8 ; Body Mass Index ; Case-Control Studies ; Female ; Humans ; Young Adult |
| Abstract: | Betatrophin, which regulates glucose metabolism, is primarily expressed in liver and fat tissue. We aimed to investigate betatrophin levels in patients with polycystic ovary syndrome (PCOS) that is the most common endocrine pathology in women of reproductive age. A total of 69 women were included in this prospective study: 35 patients with PCOS (18 obese and 17 lean) and 34 healthy controls (17 obese and 17 lean). Patients who met the criteria were compared regarding betatrophin levels and other hormonal values. Serum betatrophin level did not differ between obese PCOS patients and obese controls, and lean PCOS patients and lean controls; while significantly increased in obese PCOS patients and controls compared to lean PCOS patients and controls. Total testosterone and androstenedione were significantly higher in patients with PCOS than in controls both in the obese and lean groups, while sex hormone-binding globulin was significantly lower in patients with PCOS than in controls both in the obese and lean groups. However, remaining hormone values were similar between groups. Betatrophin level was significantly increased in obese patients compared to lean patients independent to the presence of PCOS. |
| Contributed Indexing: | Keywords: Betatrophin; PCOS; obesity; sex hormone–binding globulin; total testosterone |
| Substance Nomenclature: | 0 (ANGPTL8 protein, human); 0 (Angiopoietin-Like Protein 8); 0 (Angiopoietin-like Proteins); 0 (Peptide Hormones) |
| Entry Date(s): | Date Created: 20200305 Date Completed: 20210527 Latest Revision: 20211204 |
| Update Code: | 20260130 |
| DOI: | 10.1080/09513590.2020.1725964 |
| PMID: | 32129695 |
| Database: | MEDLINE |
Journal Article